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M Enjoji

Publications and source records attributed to M Enjoji.

At least 145 records · Page 8Linked to original sources
PubMed1987

[Current topics in the histological diagnosis of soft tissue sarcomas].

As a result of recent developments in soft tissue pathology, plus the contribution of electron microscopy and immunohistochemistry, pertinent revisions or modifications of the histological classification of soft tissue tumors published in 1969 by the World Health Organization have become necessary. Among the appreciable number of changes initiated during the last decade, the following conditions are considered remarkable and worthy of note for the histological diagnosis of human soft tissue sarcomas: dedifferentiated sarcomas, sarcomas of divergent differentiation, sarcomas with an epithelioid appearance, benign lesions mimicking a sarcoma, and newly categorized tumor entities.

Diagnosis, Differential↗
PubMed1987

Superficial leiomyomas. A clinicopathologic study of 34 cases.

The clinicopathologic findings of 34 cases of cutaneous and subcutaneous leiomyomas were described. These were composed of 12 cases of piloleiomyoma and 22 of genital leiomyoma (scrotum, nipple and areola, vulva, and perianal region). Thirteen of 22 genital leiomyomas occurred in the vulva. Four cases of leiomyoma of pilar arrector origin had multiple lesions. The tumor occurred predominantly in adult females with an approximate sex ratio of 1:3 (8 males and 26 females). The patients with such leiomyomas ranged in age from 26 to 77 with an average of 46.8 years. The histologic feature in each case was essentially the same, and composed of interlacing bundles of smooth muscle cells, although vulvar leiomyomas frequently showed varying degrees of hyalinization and were composed of more slender tumor cells. All 12 cases submitted for immunohistochemistry showed a strongly positive staining both for actin and for desmin. In our view, cutaneous and subcutaneous leiomyomas, excluding angioleiomyomas, are undoubtedly rare in occurrence.

Adult↗
PubMed1986

DNA ploidy in clinical malignant gastric lesions less than 5 mm in diameter.

Nuclear DNA content was microspectrophotometrically measured in 18 patients with a mucosal carcinoma of the stomach less than 5 mm in diameter. The findings were compared with data on 56 patients with a lesion greater than 5 mm. DNA distribution patterns were grouped into low and high ploidies. A mucosal carcinoma, classed as high ploidy, was confirmed in 27.8%, 22.2%, and 28.9% of the lesions with a diameter of less than 5 mm, 5 to 20 mm, and 20 to 40 mm, respectively. In the high-ploidy group with a lesion exceeding 5 mm, there was a preponderance of an elevated lesion, well- and moderately differentiated adenocarcinomas, and location in the lower third of the stomach. Such pathologic features showed the same tendency in the high-ploidy group with a lesion less than 5 mm. An aneuploid carcinoma may be present even in a lesion confined to the mucosa, and less than 5 mm in diameter.

Adenocarcinoma↗
PubMed1986

Intramuscular myxoma. A clinicopathologic, immunohistochemical, and electron microscopic study.

This clinicopathologic study concerns 17 cases of intramuscular myxoma, including an immunohistochemical survey of 10 cases and an electron microscopic examination of 4. There was a female preponderance in a ratio of 14:3. The most common sites of tumors were the large muscles of the thigh (seven cases), followed by those of the buttock (three) and the lower leg (three). The size of the tumor ranged from 1.5 to 20 cm (median, 6 cm) in the greatest diameter. Neither recurrence nor metastasis was seen in any of 15 patients for whom information was available. In addition to the conventional microscopic features, such as hypocellularity, absence of a plexiform capillary network, and no detection of typical glycogen-rich lipoblasts, the following findings were regarded as helpful to differentiate an intramuscular myxoma from myxoid liposarcoma: hypovascularity of the tumor, demonstrated by angiography; a homogeneous computed tomography appearance with low density, absence of S-100 protein immunoreactive cells such as lipoblasts; and electron microscopically, the constituent cells were predominantly fibroblast-like cells with a prominent secretory activity, together with a small number of primitive mesenchymal cells and histiocyte-like cells, but with no lipoblasts. After simple excision, the 15 patients who could be followed are well with no recurrence during various periods of follow-up.

Adult↗
PubMed1986

Leiomyosarcoma of the external soft tissues. A clinicopathologic, immunohistochemical, and electron microscopic study.

This clinicopathologic study concerns 25 cases of leiomyosarcoma of the external soft tissues, including an immunohistochemical survey of 19 cases and an electron microscopic examination of six. There was a female preponderance in a ratio of 16:9. The most common site of tumors was the thigh (nine cases), followed by the knee (five cases). Three tumors were located in the dermis, 9 were confined down to the subcutis, 2 involved the deep fascia, and 11 involved the skeletal muscle. Superficially located tumors were smaller than deeply located ones. According to the predominant histologic features, the tumors were classified into well (6), moderately (14), and poorly (5) differentiated. In addition to the classical microscopic features, dedifferentiated areas resembling malignant fibrous histiocytoma were noted in three primary tumors and one recurrent tumor. In six tumors, the anatomical location and histologic features were highly suggestive of leiomyosarcoma arising in the venous wall. Many tumor cells immunoreactive for actin were seen in 13 and for desmin in 9 of the 19 cases. Four tumors contained a few tumor giant cells positive for alpha-1-antichymotrypsin. Ultrastructurally, the tumors were characterized by smooth muscle tumor cells showing a spectrum of differentiation of varying degrees. In two cases, histiocyte-like tumor cells were detected. The most reliable prognostic parameter was the depth of the initial tumors; all patients with a leiomyosarcoma confined down to the subcutis are living, most of them more than 5 years after excision, whereas seven of the nine patients with a tumor involving the muscle have died within 5 years after excision.

Actins↗
PubMed1986

Giant cell tumor of the tendon sheath (nodular tenosynovitis). A study of 207 cases to compare the large joint group with the common digit group.

Clinicopathologic, enzyme histochemical, and electron microscopic findings in 207 cases (208 lesions) of giant cell tumor of tendon sheath (GCTTS) are presented. The GCTTS could be divided into two groups according to the anatomic location, the first occurring in the digits (digit group, 182 cases) and the second, in the larger joints (large joint group, 25 cases). In the majority of cases of the digit group, the tumor occurred in one of the fingers (158 cases), whereas in the large joint group, the tumor was common in the ankle (10 cases) and knee joints (8 cases). The lesion was more common in women (67%) than in men (33%). Microscopically, the GCTTS in both groups consisted of a mixture of abundant histiocyte-like, foam, and multinucleated giant cells of the osteoclast type. However, worthy of special mention were the large clefts or wide pseudoglandular spaces lined by synovial cells and that were more striking in the large joint group than in the conventional digit group. The component cells had functional properties of macrophages, as determined in the enzyme histochemical study. Electron microscopically, the tumors consisted essentially of histiocyte-like, fibroblast-like, and intermediate cells, together with myofibroblasts.

Acid Phosphatase↗
PubMed1986

Adenosquamous carcinoma of the stomach. A clinicopathologic analysis of 28 cases.

Twenty-eight cases of primary adenosquamous carcinoma (ASC) of the stomach were studied clinicopathologically. These cases were classified into two types, 16 with differentiated type adenocarcinomatous component (DAC) and 12 with undifferentiated type adenocarcinomatous component (UAC), according to the degree of glandular formation of the adenocarcinomatous elements. A large number with adenocarcinomas, including 131 with differentiated type and 133 with undifferentiated type, were studied as controls. As a consequence, with respect to biologic behavior, ASC with DAC was similar to the differentiated type adenocarcinoma, and ASC with UAC to the undifferentiated type adenocarcinoma. Accordingly, the behavioristic feature of ASC seemed to be governed by the adenocarcinomatous component. Histologically, a close relationship between neoplastic adenomatous and squamous components was evident in the intermingling areas, thereby suggesting a transition of both elements. In addition, a mucoepidermoid pattern was occasionally detected in the squamous component. Judging from the biologic behavior and histologic findings, the majority of ASC probably derives from the squamous metaplasia in an adenocarcinoma. The prognosis of ASC was less favorable than that of adenocarcinoma because of the more extensive tumor depth and higher frequencies of lymphatic and vascular permeations of the carcinoma cells.

Adenocarcinoma↗
PubMed1986

Diagnostics of small gastric carcinoma.

We studied the diagnostic features of 32 early gastric carcinomas less than or equal to 1 cm in maximum diameter, which were detected in 28 patients. A correct preoperative qualitative diagnosis was made in 19% of the lesions by means of barium studies, in 72% by endoscopy, and in 90% by endoscopic biopsy. Endoscopy and endoscopic biopsies are the most useful diagnostics for detection of these small cancers. Since most carcinomas with a diameter between 6 and 10 mm have a mucosal unevenness such as a shallow depression with an irregular perimeter and are associated with or without elevated marginal mucosa on gross inspection, it was not very difficult to detect these carcinomas with careful endoscopic observations. When endoscopists procure such evidence, biopsies should be done for confirmation. Even in ulcers that appear benign, biopsies are recommended. With regard to carcinomas of less than or equal to 5 mm in diameter, it is difficult to detect the lesions, particularly the flat-type, which make up a relatively large percentage of those minute carcinomas.

Adult↗
PubMed1986

Mucinous adenocarcinoma associated with long-standing fistula in the cecal region.

A patient with mucinous adenocarcinoma associated with long-standing chronic fistula in the cecal region is presented. Association of mucinous carcinoma with chronic fistula seems to occur not infrequently in the anal region, but is extremely rare elsewhere in the large intestine. This is the first report of an occurrence in the cecal region.

Adenocarcinoma, Mucinous↗
PubMed1986

Renal cell carcinoma in Japanese children.

Renal cell carcinoma in children is extremely rare compared to Wilms tumor. We report on a 7-year-old Japanese boy with left renal cell carcinoma. Since the disease was clinical stage I, nephrectomy with tumor extirpation was performed after a short course of initial chemotherapy had been administered. The patient is free of disease 3 years postoperatively. In a review of the Japanese literature we found 71 reports of renal cell carcinoma in children less than 15 years old. Mean patient age at occurrence was 8.1 years, there were no differences in regard to the sex or the affected side, and the most frequent symptom was the presence of a mass. We stress the early establishment of diagnosis in children with a persistent abdominal mass, hematuria and flank pain, since surgical treatment leads to a favorable prognosis only in the early stage of renal cell carcinoma.

Adolescent↗
PubMed1986

Kaposi's sarcoma in a Korean living in Japan. Review of cases reported in Japanese literature.

An 87-year-old male Korean living in Japan had the typical classic lesions of Kaposi's sarcoma on the extremities. Numerous red-purple nodules and plaques were observed on the edematous forearms and lower extremities. Histologic examination revealed an extensive proliferation of spindle cells and large endothelial cells, which were both positive for factor VIII-related antigens. The patient's sera were positive for IgG antibodies to late antigens of cytomegalovirus and negative for IgM antibodies to late antigens of cytomegalovirus and for IgG antibodies to early antigens of cytomegalovirus. Cytomegalovirus-related antigens were detected in the nucleus or cytoplasm of cells in the biopsy specimens by the anticomplement immunofluorescence (ACIF) test. These results suggest that cytomegalovirus infection might play a role in the development of Kaposi's sarcoma, though it is premature to draw any definite conclusion in this connection. In addition, the characteristics of histologic and clinical findings of Kaposi's sarcoma cases reported in the Japanese literature have been discussed.

Aged↗
PubMed1986

Pigmented villonodular synovitis. A clinicopathologic study of 52 cases.

Clinicopathologic, enzyme histochemical and electron microscopic findings in 52 patients with pigmented villonodular synovitis (PVS) are reported. The lesion was by far the most common in the knee joint (48%), followed by the ankle joint (25%). As to sex incidence, there seemed to be no predilection (46% in men, 54% in women). Microscopically, the PVS showed thin or thick villous projections of the involved synovial membrane, associated with or without nodular formation. The nodule of PVS consisted essentially of a proliferation of histiocyte-like cells with phagocytic activities. Another characteristic feature was large clefts and pseudoglandular or alveolar spaces lined by synovial cells. Enzyme histochemical studies revealed that the lesional cells had functional properties of macrophages. Electron microscopically, the lesion consisted essentially of histiocyte-like and fibroblast-like cells, together with intermediate cells and myofibroblasts.

Adolescent↗
PubMed1986

Giant-cell reparative granuloma of the thoracic vertebra.

Giant-cell reparative granuloma occurring in the thoracic vertebra of a 16-year-old girl is presented, and the literature concerning the subject is reviewed. This report is of the second documented case with this essentially rare lesion arising in the vertebra. Microscopically, the lesion was characterized by a reactive granulation tissue with formation of reactive osteoid, collagenization and vascularization, and focal accumulations of giant cells, particularly around hemorrhagic portions. The patient is doing well without further recurrence 38 months after the second therapeutic curettage. The authors describe the clinicopathologic features of this particular case because of its rarity in location, and briefly discuss the difference from other giant-cell lesions of bone mainly in view of differential diagnosis.

Adolescent↗
PubMed1986

Invasive lobular carcinoma of the breast. An analysis of 29 cases.

Twenty-nine cases of invasive lobular carcinoma were analyzed, based on three aspects of the histology: 1) cellular features such as a monotonous proliferation of uniform small cells, 2) a single file or targetoid arrangement, and 3) loss of cell cohesion or dissociation of tumor cells. Twenty-four tumors which fulfilled these three criteria were appraised as cases of conventional lobular carcinoma, in a classic sense, while five others were a variant of this tumor. Individual tumor cells of lobular carcinoma were estimated to be well differentiated, both morphologically and functionally, revealing well developed intracytoplasmic organelles and a high percentage of alpha-lactalbumin content in the cytoplasm. Nevertheless, the tumor itself was characterized by a lack of any particular structural differentiation in the arrangement of cells. Based on the observation of the histologic features, invasive lobular carcinoma was subclassified into three groups, in situ predominant, intermediate, and diffuse infiltrating and with a definite correlation to the age of the patient and to the prognosis. Validity of this classification indicates that lobular carcinoma progresses gradually, even in the invasive phase, and can be categorized as a slowly growing subset of mammary carcinoma.

Adult↗
PubMed1986

Carcinosarcoma of the gallbladder. Report of a case and review of the literature.

An extremely rare case of carcinosarcoma of the gallbladder is reported. The tumor presenting as a large, soft polypoid growth was microscopically characterized by an admixture of adenocarcinomatous and sarcomatous elements, the latter containing specific heterologous mesenchymal elements such as osteoid, cartilage, and rhabdomyoblasts. The cytoplasm of neoplastic rhabdomyoblasts offered unequivocal cross striations and was strongly positive for myoglobin, determined by the immunoperoxidase procedure. Metastatic tumors in the liver also exhibited a dual composition of adenocarcinoma and rhabdomyosarcoma. This appears to be the second documented case of this type of neoplasm with the rhabdomyosarcomatous component. The clinical settings and morbid prognosis were similar to events in cases of carcinoma of the gallbladder.

Carcinosarcoma↗
PubMed1986

Squamous cell carcinoma of the stomach: report of three cases.

Three primary tumors of the stomach diagnosed as pure squamous cell carcinoma were reexamined with newly prepared multiple sections. In each tumor histological studies revealed minute areas of adenocarcinoma in addition to large areas of squamous cell carcinoma. This finding suggests that some gastric squamous cell carcinomas may be adenosquamous carcinomas with a predominant squamous component. The pathogenesis of primary squamous cell carcinoma of the stomach is discussed with respect to our observations and with due reference to the literature. The aggressive behavior of this tumor is also given attention.

Adenocarcinoma↗