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Biomedical subjects

M Enjoji

Publications and source records attributed to M Enjoji.

At least 181 records · Page 10Linked to original sources
PubMed1984

Angioleiomyoma. A clinicopathologic reappraisal of 562 cases.

Five hundred sixty-two cases of angioleiomyoma in our files on soft tissues were reappraised clinicopathologically. There was a preponderance in females with a ratio of 1.7:1. The angioleiomyoma could be separated into three histologic subtypes: capillary or solid (374 cases), cavernous (61 cases), and venous (127 cases) types. Five hundred (89%) occurrences were in the extremities, 48 in the head, and only 14 in the trunk. The tumors caused pain and/or tenderness in 327 cases, in which 262 were of the solid type. In 16 cases, small groups of mature fat cells were demonstrated within the tumor, suggesting the hamartomatous nature of these smooth muscle tumors.

Adolescent↗
PubMed1984

S-100 protein distribution in liposarcoma. An immunoperoxidase study with special reference to the distinction of liposarcoma from myxoid malignant fibrous histiocytoma.

The presence and distribution of S-100 protein were studied in 63 cases of liposarcoma and 20 cases of myxoid malignant fibrous histiocytoma (MFH), using the immunoperoxidase technique. Normal adipose tissue and benign lipomatous tumours were also studied by the same technique, for purposes of comparison. In all liposarcomas, most of the adipocytes and vacuolated lipoblasts were positive for S-100 protein, although the tumour cells in non-lipogenic areas of dedifferentiated liposarcoma and the non-vacuolated giant cells with a deeply eosinophilic cytoplasm in the pleomorphic liposarcomas were devoid of S-100 protein immunoreaction products. One third of the myxoid type liposarcomas contained numerous immunoreactive, immature-appearing spindle or oval cells, reminiscent of the primitive fat organs of white adipose tissue. Conversely, none of the myxoid MFHs contained S-100 protein in the tumour cells, including the irregularly vacuolated ones. These results suggests that the immunohistochemical demonstration of S-100 protein is a useful diagnostic tool, particularly for the assessment of vacuolated tumour cells and for the diagnosis of myxoid tumours.

Adipose Tissue↗
PubMed1984

Growth patterns of gastric carcinoma detected by mass survey.

Two hundred and sixty-seven cases of gastric carcinoma detected by mass survey included 196 discovered at the first examination (Group A) and 71 noted at the annual sequential examination (Group B) were analyzed in terms of growth pattern and prognosis. The incidence of early carcinoma was 54.9 per cent in Group B higher than 35.7 per cent in Group A. In early carcinoma, the superficially spreading (SUPER) type of carcinoma was more common in Group A than in Group B. On the contrary, the penetrating growth (PEN) type of carcinoma was more frequently found in Group B than in Group A. About eighty per cent of those with an advanced carcinoma, in both groups, was the advanced PEN type. The outcome of the patients in Group B was more favorable. These results support the hypothesis that the majority of advanced carcinoma is derived from the PEN type of early carcinoma. Early detection of the PEN type of carcinoma is mandatory.

Humans↗
PubMed1984

Malignant "triton" tumors: a clinicopathologic and immunohistochemical study of nine cases.

Nine cases of malignant "triton" tumors, based on the coexistence of rhabdomyoblasts and Schwann cell elements, were analyzed clinicopathologically and immunocytochemically. All tumors were stained for myoglobin and S-100 protein by the immunoperoxidase technique. Six of the nine patients were in the third or fourth decade of life. Six cases were associated with von Recklinghausen's disease, and the tumors in two cases grew along nerve trunks. The malignant tumors showed a predilection for the thigh and buttock. Six of the seven deaths occurred within two years of the initial treatments. Strongly positive staining for S-100 protein was observed in three tumors, with transitional zones between the sarcomas and peripheral neurofibroma-like areas, as well as in two tumors composed predominantly of rhabdomyoblastic elements. In four other cases the tumors were only weakly positive for protein S-100. Intracytoplasmic myoglobin was present in all cases. Tumors composed predominantly of rhabdomyosarcomatous elements occurred in four patients, including two children with von Recklinghausen's disease. These results, considered with other findings, suggest that malignant "triton" tumors may not be as rare as previously believed.

Abdominal Muscles↗
PubMed1984

Malignant hemangiopericytoma and other sarcomas with hemangiopericytoma-like pattern.

This clinicopathologic study concerns 19 cases of malignant hemangiopericytoma among 755 cases of soft tissue sarcomas. The age of the patients ranged from 18 to 76 years, with a median of 43 years. Tumors occurred on the trunk in 8, lower extremities in 5, the head in 3, and the retroperitoneum in 3. According to follow-up information, nine of the 19 patients had died. Histologically the tumor was characterized by its homogeneous vascular pattern, its uniform cell population and a wide range of cellular anaplasia. After extensive sampling of the tumors, a comparative light microscopy revealed differences in diagnostic histology between malignant hemangiopericytoma and other soft tissue sarcomas with a hemangiopericytoma-like vascular pattern. The frequency of appearance of such pericytoma pattern in different soft tissue sarcomas was as follows: 4/4 cases (100%) in extraskeletal mesenchymal chondrosarcoma, 11/14 (79%) in infantile fibrosarcoma, 27/45 (60%) in synovial sarcoma, 62/201 (30%) in malignant fibrous histiocytoma, 9/37 (25%) in malignant schwannoma and 6/72 (8%) in liposarcoma.

Adolescent↗
PubMed1984

Diagnosis of soft tissue sarcomas.

Based on a review of 752 cases coded as soft tissue sarcomas, histologic features were analyzed for a differential diagnosis, dividing the sarcomas in the first diagnostic step into purely descriptive groups, regardless of biologic behavior: spindle cell, small cell, pleomorphic and myxoid varieties. The tumor categories mainly discussed in order were fibrosarcoma, leiomyosarcoma, malignant schwannoma, synovial sarcoma, malignant fibrous histiocytoma, embryonal and alveolar rhabdomyosarcoma, malignant neuroepithelioma , extraskeletal Ewing's sarcoma, and myxoid and other types of liposarcoma. The discussion was focused on the problems we were facing often in the histologic diagnosis of these tumors, emphasizing in particular those microscopic features which were helpful in differential diagnosis. Principal clinical features, important for an accurate diagnosis, were added to the histopathologic considerations in each item, together with prognosis of all these Japanese patients, regardless of the stages. Other benign and malignant lesions confused occasionally with the soft tissue sarcomas were also listed. With the aid of electron microscopy and immunohistochemistry, sometimes each differentiating feature can be identified but these methods are not always contributory to a diagnosis. Routine light microscopy with or without standard histochemical techniques remains essential to avoid pitfalls when attempting to diagnose the tumor.

Chondrosarcoma↗
PubMed1984

Simultaneous occurrence of primary carcinoma and chondrosarcoma in the liver. A case report and a review of the literature.

We treated a 67-year-old man with primary carcinoma and sarcoma arising from the different areas of the cirrhotic liver. Histologically the carcinoma was of hepatocellular origin and the sarcoma consisted mainly of poorly differentiated mesenchymal cells partly with a chondrosarcomatous component. Among nine similar cases reported in the literature, only one was a rhabdomyosarcoma and the others were described simply as of spindle cell variety without evidence of mesenchymal differentiation. In the present case, the sarcoma consisted of mesenchymal cells with distinctive areas of unequivocal chondrosarcoma.

Aged↗
PubMed1984

Dupuytren type fibromatoses. A clinicopathologic study of 62 cases.

This clinicopathologic study concerns 62 patients with one of the Dupuytren type fibromatoses. Of the 62 patients, 42 had the lesion in the palm (palmar fibromatosis), 12 in the sole (plantar fibromatosis), 2 in the penis (penile fibromatosis), and 6 in the ectopic locations, the dorsal aspect of the hand in 3 patients, the dorsum of the fingers in 2, and the forearm in 1. The clinically palpable nodules were histologically classified into those of the following three phases, according to LUCK'S classification: proliferative phase (27), involutional phase (23), and residual phase (12). In addition to fibroblastic proliferation, the lesion of the proliferative phase exhibited vascular features consisting of one or more layers of cells with oval nuclei around the vessels within the nodule. In the lesions of the late proliferative and involutional phase, the intracytoplasmic fine filaments were visible in cells compatible with myofibroblasts by Masson's trichrome stain. The nuclei of the elemental fibroblasts in the same phases were often crossed transversely by one or more fine basophilic lines.

Adolescent↗
PubMed1984

Nodular fasciitis: an analysis of 250 patients.

A clinicopathological analysis was made of data from 250 cases of nodular fasciitis. These benign nodules usually occurred in young and middle-aged adults in the 4th and 5th decades, most often in the forearm (27%) followed by the thigh (17%) and the upper arm (12%), and grew rather rapidly to reach a mean diameter of 1.5 cm, usually with slight tenderness. Lesions in nodular fasciitis could be separated into 3 types based on a range of histological features, modified from those of Price et al.: myxoid, cellular and fibrous. This subgrouping seemed to cover adequately the spectrum of histological appearances observed in nodular fasciitis. It was roughly correlated with the duration of the nodule. The mitotically active myxoid form tended to have the shortest history, the fibrous the longest, while that of the cellular group was of intermediate duration.

Adolescent↗
PubMed1983

Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding.

Cell cultures were carried out from four patients with infantile digital fibromatosis. The cultured cells, which contained cytoplasmic inclusions identical to those of the original tumor cells, possessed cortical bundles of microfilaments, rich network of granular endoplasmic reticulum, and well-developed Golgi complex. To demonstrate the distribution of actin filaments in the cultured cells, the heavy meromyosin-binding method was applied to saponin-treated cells from one of the four patients. The microfilaments constituting the inclusions as well as the cortical bundles were decorated with heavy meromyosin, presenting the "arrowhead complexes" specific for actin filaments. The inclusion may represent abnormal contraction of actin filaments in the cytoplasm of myofibroblasts.

Actins↗
PubMed1983

Myxoid malignant fibrous histiocytoma versus myxoid liposarcoma. A comparative ultrastructural study.

An ultrastructural comparison of 7 examples of myxoid malignant fibrous histiocytoma (myxoid MFH) with 6 of myxoid liposarcoma is described. Despite certain histological differences between the two, electron microscopy was more valuable in differentiating MFH from liposarcoma. Electron microscopically, MFH contained a variety of cell types including histiocyte-like, fibroblast-like, intermediate-type, xanthomatous, multinucleated tumor giant cells and undifferentiated cells. Liposarcoma was composed mainly of lipoblasts at various stages of differentiation with a minority of undifferentiated cells and fibroblast-like cells. In contrast to the component cells of the MFH, these lipoblasts were characterized by abundant cytoplasmic glycogen, numerous pinocytotic vesicles and a discontinuous basal lamina in addition to large lipid droplets.

Adult↗
PubMed1983

Pseudosarcomatous carcinoma of the anal canal.

A polypoid pseudosarcoma of the anal canal in a 45-year-old woman was surgically treated. Morphologic characteristics of the tumor were essentially identical with those in hitherto-described pseudosarcomas of the esophagus, larynx, fauces, or oral cavity. Histologic features of the tumor support the presumption of epithelial origin of the sarcoma-like element on the basis of the presence of a clearly epithelial element in the sarcoma-like areas, justifying the term "pseudosarcomatous carcinoma," instead of "pseudosarcoma." This is the first report of this tumor type detected in the anal canal.

Carcinoma↗
PubMed1983

Intravascular papillary endothelial hyperplasia. A clinicopathologic study of 91 cases.

Ninety-one cases of intravascular papillary endothelial hyperplasia were studied clinically and histologically. This peculiar benign process, occasionally resembling hemangiosarcoma, was subgrouped in the following categories: a pure form that occurs within a dilated vascular space (30 cases), a mixed form that appears as a focal change in a hemangioma (55 cases), a third form (six cases) that belongs to neither of the first two. In the pure form, the lesions were most frequently situated in the subcutis of fingers (14 cases), of the head and neck (seven cases), and in the region between the elbows and hands (six cases). In the mixed form, half of the accompanying hemangiomas were intramuscular in no particular predilective sites. Papillary proliferation of endothelial cells was commonly found to be closely associated with thrombotic material and seemed to be an unusual feature of a thrombus undergoing organization.

Adolescent↗
PubMed1983

Malignant neuroepithelioma (peripheral neuroblastoma). A clinicopathologic study of 15 cases.

A clinicopathologic study of 15 cases of malignant neuroepithelioma (peripheral neuroblastoma) of soft tissues is reported. The patients were chiefly young Japanese adults with a median age of 21 years. The tumors arose mainly in the soft tissues of the lower extremity (seven cases) and the trunk (four cases). Microscopically, there were sheets of closely packed, small round or oval cells, and Homer Wright-type rosettes were seen in all cases, one of which also had Flexner-type rosettes. Immunohistochemical cytoplasmic localization of neuron-specific enolase (NSE) was demonstrated in six of the eight cases, using the peroxidase-antiperoxidase (PAP) method. In no case, however, was there any staining reaction for S-100 protein. Of the 14 patients for whom follow-up information could be obtained, nine died within a period of 2 years and two were alive and well for over 5 years after the initial treatment. Differential diagnosis from other soft-tissue round-cell sarcomas, such as embryonal or alveolar rhabdomyosarcoma, extraskeletal Ewing's sarcoma, and others, are briefly discussed, on a clinicopathologic basis.

Adolescent↗
PubMed1983

Extremely well-differentiated adenocarcinoma ("adenoma malignum") of the cervix.

Eight cases of extremely well-differentiated adenocarcinoma of the cervix were collected for clinicohistopathologic study. The tumors, despite having an innocuous histologic appearance, were characterized by irregular shapes and various sizes of the glands, with intraluminal papillary projections supported by thin connective tissue cores. They showed, in addition, sharp outpouching and distension of the malignant glands by mucin, as well as leakage into stroma. Clinically, such tumors were highly malignant and the prognosis was poor. Six patients died within 3 years following surgical treatment. In six of the eight cases, Feulgen microspectrophotometric DNA measurements disclosed patterns similar to those of normal endocervical glands, except for 4c to 6c aneuploid cells.

Adenocarcinoma↗
PubMed1983

Juvenile aponeurotic fibroma: an ultrastructural study.

The light and electron microscopic findings in a case of juvenile aponeurotic fibroma are described. The tumor was composed of fibromatosislike areas and cartilagelike islands with characteristic calcification. The ultrastructural study verified the cartilaginous nature of this tumor. The cartilagelike islands were made up of chondrocytic cells embedded in an abundant intercellular matrix containing fine fibrils, spherical granules, and pleomorphic membrane-bound vesicles. The chondrocytic cells had many microvilli, a well-developed granular endoplasmic reticulum, and a prominent Golgi complex. In the periphery of each cartilagelike island was a perichondriumlike structure exhibiting transitional features from fibroblastic cells to chondrocytic cells. The fibromatosislike areas consisted of spindle-shaped fibroblastic cells and occasional myofibroblasts. The morphologic pattern of the tumor somewhat mimics embryonal chondrogenesis, and the fibromatosislike areas may represent an overgrowth of the fibrous layer of the perichondrium. It is possible to regard this tumor as an organoid tumor having a capacity for bidirectional differentiation into cartilage and fibrous tissue.

Adult↗
PubMed1983

Synovial sarcoma. A clinicopathologic and ultrastructural study of 42 cases.

This clinicopathologic study concerns 42 cases of synovial sarcoma (13 biphasic and 29 monophasic), including electron-microscopic examination of five cases, among 753 cases of soft tissue sarcomas. The age of the patients ranged from 9 to 70 years, with a median of 35 years. Tumors occurred most commonly on the extremities with 31 on the lower extremities. Histologically the monophasic type on this occasion included tumors with focal or minimal biphasic differentiation (9 cases) in addition to totally monophasic tumor (20 cases). A comparative light microscopy revealed otherwise inappreciable differences in histologic characteristics between the monophasic synovial sarcoma and certain other spindle cell sarcomas. Ultrastructurally, the cells composing the spindle-cell area of the synovial sarcoma contained basically the same elements as did the cells forming epithelioid or gland-like structures, and as the cells in the areas of gradual transitions of the two. One exception was that the cells lining the gland-like lumina had microvillar projections. Characteristic secretory-like granules, similar to those seen in the synovial type B cell of the normal human synovium, were evident in all five cases studied electron microscopically. In contrast to the findings of others, patients with monophasic tumors had a better prognosis, 58% surviving 5 years compared to 36% for those with biphasic tumors.

Adolescent↗