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Biomedical subjects

M Endo

Publications and source records attributed to M Endo.

At least 901 records · Page 50Linked to original sources
PubMed1985

Demonstration of chondroitin sulfates degrading endo-beta-glucuronidase activity in rabbit liver.

Reduced chondroitin sulfate was incubated with rabbit liver extracts followed by reduction once more with sodium [3H]borohydride, and then passed through a Sephadex G-100 column. Chondroitin sulfate obtained from the incubation medium at pH 4 was only slightly depolymerized and was highly radioactive. Paper chromatographic analyses showed that glucuronic acid residues became exposed at the reducing terminal of chondroitin sulfate after incubation with the liver extracts. These results suggest that endo-beta-glucuronidase activity which degrades chondroitin sulfate is present in the rabbit liver.

Animals↗
PubMed1985

Electroencephalographic findings in neuroacanthocytosis.

This study reports the electroencephalographic findings in two siblings with neuroacanthocytosis. Slowing of the background activity with diffuse slow waves was the main finding in the daytime EEG. All-night polysomnographic recordings were characterized by high voltage slow activity during drowsy state and REM sleep. One patient with an average of 40 episodes of apnea per night of sleep was treated with imipramine and showed respiratory improvement.

Acanthocytes↗
PubMed1985

The use of computerized tomography to evaluate anorectal anomalies.

Computerized tomography (CT) was applied to various types of anorectal anomalies to directly image the anal sphincters. In normal cases and low type anomalies, CT demonstrated clear images of the puborectal muscle and external sphincters. Among high type anomalies, the distribution of sphincter muscle in patients with rectovesical fistula is totally different from that seen in patients with rectourethral fistula. In the latter, the puborectal muscle is attached not only around urethra, but also around the distal part of the blind rectum; external sphincters are present as a mass beneath the perineum. In the rectovesical fistula, however, the puborectal muscle cannot be identified and the external sphincters exist only as a string-like structure. CT done postoperatively identified two different causes for incontinence. In one type, the pull-through colon missed the sphincteric musculature, and in the other, sphincters were markedly hypoplastic. CT, therefore, provides adequate imaging to determine the type of operation needed to correct the abnormality.

Anal Canal↗
PubMed1985

Duration of ENNG administration and its effect on histological differentiation of experimental gastric cancer.

An experimental trial in the induction of canine gastric cancers was conducted to study the relationship between the histological differentiation of adenocarcinoma and the duration of administration of the carcinogen, N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). Twenty-three adult Beagle dogs were divided into three groups according to the duration of administration. Over 3 months administration, the total dose of ENNG per animal was 5.85 g, and only signet ring cell carcinomas and poorly differentiated adenocarcinomas were induced in the antral mucosa of the stomach in 5 of 10 recipients. During 6 and 9 months administration, the total doses per animal were 11.70 g and 17.55 g, well differentiated adenocarcinomas were observed in 12 of 13 animals and they coexisted with poorly differentiated adenocarcinomas and/or signet ring cell carcinomas. Atrophic hyperplastic gastritis and hyperplastic polyps were seen in the same stomach. The results of this study suggest that a greater amount of carcinogen, i.e., a higher total dose, is required for the development of well differentiated adenocarcinoma than for inducing poorly differentiated adenocarcinoma and signet ring cell carcinoma.

Adenocarcinoma↗
PubMed1985

Reconstruction of the pharyngoesophagus following pharyngoesophagectomy and irradiation therapy.

During the 5-year period between 1978 and 1983, a total of 56 individuals have undergone pharyngoesophageal reconstruction at our hospitals. To restore the continuity of the upper enteric tract, conventional skin flaps with or without the underlying muscle were used in 27 and a segmental free intestinal graft by means of microvascular technique was used in 29. Two-thirds of both groups received irradiation therapy before surgery. Fistula formation was encountered in 8 individuals who received a skin flap. This incidence was found to increase with the use of preoperative irradiation. In contrast, no patient developed a fistula among the 29 patients who received the segmental free intestinal graft.

Aged↗
PubMed1985

Handedness conversion in children and parental handedness.

In order to find out which factor, genetic or environmental, is more involved in determining hand usage, the distribution of handedness in Japanese senior high school students and the success of their parents' attempts at conversion of handedness was investigated with respect to four pairings of parental handedness. When a child's handedness was related to that of the parent, children of a left-handed parent were more likely to be non-right-handed than those of both right-handed parents. There was no significant relation between parental handedness and the rate of handedness conversion of children. The results are in favor of the view that human handedness is genetically rather than forcibly determined by parents, although environmental factors such as parents' interference are involved in decreasing the incidence of non-right-handedness in Japan.

Child Rearing↗
PubMed1985

Hand preference in schizophrenics and handedness conversion in their childhood.

A handedness questionnaire which was given to 1774 schizophrenic inpatients was identical to that employed in our previous study on healthy students. Information was obtained on forced conversion of hand usage in childhood and the occurrence of left-handedness in their families. Family history of schizophrenia was also investigated. There were no significant differences in the prevalence of left-handedness or non-right-handedness (i.e., left-handedness and ambidexterity combined) between schizophrenic patients and normal subjects. However, the rate of converted right-handedness in schizophrenics was higher than that in normal people. The incidence of original non-right-handedness (i.e., present non-right-handedness and converted right-handedness combined) in schizophrenics was greater than that in normal controls.

Adolescent↗
PubMed1985

A Japanese survey on first attempts of percutaneous transluminal coronary angioplasty.

Experiences of the initial application of percutaneous transluminal coronary angioplasty (PTCA) in Japan performed during 1980-1981 at the multicenter level were analyzed. A survey in 72 cases which were collected from 12 centers showed an overall success rate of 64.7%, unimproved stenotic lesions in 8.1% and unpassable lesions in 24.3% of the cases. Complications were death of the patient in 2(2.8%), acute myocardial infarction in 6(8.3%) and dissection of the coronary artery in 3 cases (4.2%). Aortocoronary bypass graft surgery was performed in 8 cases (11.1%).

Adult↗
PubMed1985

Our experience of coronary intervention. Intracoronary guide wire recanalization and percutaneous transluminal coronary angioplasty.

Our old and new trials of coronary intervention therapy are introduced and analyzed. A method using intracoronary guide wire recanalization (Endo's method) is introduced. Two unusual cases of percutaneous transluminal coronary angioplasty (PTCA) from our initial experience of 18 cases are also presented. One is a 60-year-old patient who had transient complete right bundle branch block in a post-PTCA treadmill test. The other is a 45-year-old patient with unstable angina who developed myocardial infarction right after the PTCA but in whom post-PTCA coronary arteriography showed no apparent stenosis at the site of the PTCA.

Angioplasty, Balloon↗
PubMed1985

Surgical treatment for infective endocarditis--decision tree for the treatment and introduction of translocation method.

Persistent fever during active-phase IE is an indication for surgical treatment in the light of the causative organism and the underlying disease. To counter worsening hemodynamics, surgery may be the only feasible way. Surgery is performed when the patient does not respond to vasodilators and he shows an FS of less than 25%. The introduction of translocation provides a solution for the treatment of active IE. Lesions, vegetations more than 5 mm in diameter, periannular abscess, and mycotic aneurysm that could never be overlooked by two-dimensional echocardiography may hasten the early-stage decision of ways to treat IE.

Adult↗
PubMed1985

Improved myocardial ischemia and left ventricular function during exercise after successful percutaneous transluminal coronary angioplasty.

Percutaneous transluminal coronary angioplasty (PTCA) was performed in 42 patients with effort angina, 28 (67%) of them underwent successful angioplasty. Treadmill exercise testing, thallium-201 myocardial scintigraphy and radionuclide ventriculography were performed before and after PTCA for evaluation of the improvement of myocardial ischemia and left ventricular function at rest and during exercise. The average exercise duration by treadmill testing in 14 successful cases increased from 14 +/- 4 (mean +/- S.D.) to 16 +/- 2 minutes (p less than 0.05). Sixteen of 28 the patients were studied by thallium-201 myocardial scintigraphy. Before PTCA, regions of decreased thallium-201 uptake after exercise were observed in 12 of the 16 patients. After angioplasty, no distinct defects were recognizable in 9 of the 12 patients, and in the remaining three, a significant decrease in defects was recognized. Fifteen of the 28 patients were studied by radionuclide ventriculography. The mean ejection fraction was 61 +/- 5% at rest and 56 +/- 11% during exercise (N.S.) before PTCA. After angioplasty, the ejection fraction was unchanged at rest (61 +/- 5 to 62 +/- 4%), but increased significantly during exercise (62 +/- 4 to 74 +/- 4%, p less than 0.001). In conclusion, left ventricular function was improved by successful PTCA due to improvement of myocardial ischemia. The long term results require further study.

Adult↗
PubMed1985

Experience of emergency coronary artery bypass grafting surgery and operative transluminal coronary angioplasty.

Our experience of performing emergency coronary artery bypass surgery in 9 patients with acute myocardial infarction (AMI) and of intraoperative transluminal coronary angioplasty (OTCA) during bypass surgery in another 28 patients was reviewed. Data were evaluated in conjunction with the recent application of intracoronary thrombolytic therapy and percutaneous transluminal coronary angioplasty. In 4 of the 9 cases where the emergency coronary artery bypass grafting (CABG) was performed within 2 hours after the onset of AMI, no new Q waves appeared in electrocardiograms (3 cases), and remarkable improvement of left ventriculographic findings was noted when pre- and postoperative ventriculograms were compared in 2 of these 4 cases. Intraoperative transluminal coronary angioplasty was successful in only 51.6% of the cases when evaluated at the post bypass period and this was less successful than our experience with PTCA. The low success rate was considered to be due to the greater amount of intimal fibrosis in the more distal portion, where the OTCA is performed, than is found in the proximal portion of the coronary arteries.

Adult↗
PubMed1985

Reducing terminals of urinary chondroitin sulfate.

Human urinary chondroitin sulfate isolated from the cetylpyridinium chloride-complex of the non-dialyzable fraction of the pooled urine was subjected to ethanol fractionation, successive enzymic digestion with neuraminidase and mucopolysaccharidases, and anion exchange chromatography. The gas liquid chromatographic analyses of the acetyl and butaneboronic acid ester derivatives of the reduced terminal sugar units after treatment with sodium borohydride plus hydrolysis revealed that 42% of the urinary chondroitin sulfate was bound to peptide through xylose. The reducing terminal sugar units of the peptide-free form consisted of 34.6% of xylose, 22.4% of galactose, 16.4% of glucose of unknown origin and 26.6% of glucuronic acid. These observations showed that the xyloside, galactoside and glucuronide linkages at non-terminal sites of carbohydrate chains of chondroitin sulfate were cleaved in tissues. It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase, which act on proteochondroitin sulfate are present in tissues.

Amino Acids↗
PubMed1985

Urinary glycosaminoglycans bearing glucuronic acid or iduronic acid residue at the reducing terminals.

The urinary glycosaminoglycan was reduced with NaB[3H]4, and was separated into three fractions according to molecular size by column chromatography on Sephadex G-200. The hexuronic acid residues at the reducing terminals of each fraction were quantified by the method of preferential quantitation of hexuronic acid at the reducing terminals. This method consisted of hydrolysis with trifluoroacetic acid and nitrous acid, lactonization, and paper chromatographic analysis. Both radioactive gulonolactone and idonolactone were detected in the fractions with a lower molecular size, but not in those with a higher molecular size. These observations demonstrated that the glucuronide and iduronide linkages at other-than-terminal sites of carbohydrate chains were cleaved by the processes of depolymerization of glycosaminoglycans in tissues. Therefore, it is highly likely that endo-beta-glucuronidase(s) and endo-alpha-iduronidase(s) which belong to the glycosidase of endo type such as hyaluronidase are involved in the catabolic degradation of glycosaminoglycans in tissues.

Carbohydrate Sequence↗