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Biomedical subjects

M Endo

Publications and source records attributed to M Endo.

At least 811 records · Page 45Linked to original sources
PubMed1988

[Clinical evaluation of adjuvant radiotherapy and chemotherapy for esophageal carcinoma].

Surgical treatment is the most effective therapy for esophageal carcinoma, and adjuvant radiotherapy and chemotherapy are essential for the improvement of postoperative curability. The recurrence of carcinoma after curative surgery is often observed in the upper mediastinum and cervical portion. Fifty Gy of postoperative prophylactic irradiation has been given routinely and this has suppressed the local recurrence of the disease to a remarkable degree. Metastasis of carcinoma to internal organs was not controlled by radiotherapy. This occurs in the case of undifferentiated carcinoma, severe lymph node metastasis and positive invasion to vessels. Cisplatin, vindesine and bleomycin (DVB) combination chemotherapy and another cisplatin-based chemotherapy have been adapted for postoperative cases such as those in stages II, III and IV with radiotherapy. Cases of stage 0 and I with positive carcinomatous invasion to vessels have been treated reasonably with anti-cancer agents. Before chemotherapy, the anti-cancer activities of the drugs in subrenal capsule assay (SRCA) are tested using resected tumors and prospective clinical trials are being performed.

Animals↗
PubMed1988

Fundamental tumor perfusion analysis with nuclear magnetic resonance imaging using gadolinium-diethylene triamine pentaacetic acid.

The measurement of blood perfusion is an important factor for both the diagnosis and follow-up of tumor lesions. However, noninvasive detection of this local blood flow factor is very difficult. To accomplish this, we tried to calculate tissue blood perfusion indexes with nuclear magnetic resonance imaging using gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA). We experimentally applied this method to C3H mouse's tumor NFSa (fibrosarcoma) and its recurrence tumor R1137, whose experimental hypoxic cell fraction is different; that is, R1137 is more oxic than NFSa. Imaging pulse sequence was T1 (TR = 1,000 ms, TI = 300 ms), and longitudinal relaxation rate (R1 = 1/T1) values were calculated. Injected dose of Gd-DTPA was 0.1 mmol/kg. The T1 images produced are from both the preinjection period from every 5 min postinjection for 30 min. Using two-exponential analysis and compartment analysis we calculated two fundamental parameters: uptake index and flow index as blood perfusion factors. We found that this method has the possibility of differentiating the tissue's hypoxic cell fraction and is effective both for follow-up study after radiation therapy and for tissue characterization.

Animals↗
PubMed1988

[Evaluation of the long-term survival rate of thoracic esophageal cancer].

The 5-year survival rate of 906 cases of thoracic esophageal cancer was 23%. Related to sex distribution, it was significantly better in women. Age distribution and location of cancer had no particular correlation to the 5-year survival rate. It increased in the length of the filling defect less than 6 cm and reduced when the length exceeded 10 cm. The 5-year survival rate of the cases a0 was much better than those a1, a2 and a3. That of the cases a3 was much worse than those not only a0 but also a1 and a2. The relation between lymph node metastasis and the 5-year survival rate was shown as follows; the 5-year survival rate of n(-) cases was extremely superior to that of n(+) cases and that of n3(+) and n4(+) cases was worse than that of n1(+) and n2(+) cases. The 5-year survival rate of the cases of stage IV was quite poor. There was found a significant difference between the curative resection group of C II and C III, and the non-curative resection group of CO and CI. The 5-year survival in the cases of squamous cell carcinoma of the well differentiated type was better than that in those of squamous cell carcinoma of the moderately and poorly differentiated types. That of the cases of adenocarcinoma was good, though the number of cases was not so many.

Adenocarcinoma↗
PubMed1988

[Clinical study of "stent creep" in porcine bioprosthesis].

Stent creep is often associated with malfunction of bioprosthesis. We measured the inward bending angle of the stent-post showing maximum bending (IBA) on 42 mitral porcine xenografts retrieved 1 to 12 yrs (mean 7.7 yrs) postoperatively at reoperation. Patients were 12 men and 28 women, ranging in age from 26 to 58 yrs. Mean +/- S.D. for IBA was 12.7 +/- 4.2 degrees(ds) in 14 valves being implanted for less than 7 yrs and 16.9 +/- 5.5 ds in 28 valves longer than 8 yrs (p less than 0.05). There was a significant difference in IBA between 36 valves of 25-29 mm size (16.3 +/- 5.1 ds) and 6 valves of 31 mm (10.3 +/- 5.5 ds) (p less than 0.05), but no significant difference between 23 Hancock valves (15.5 +/- 4.4 ds), 10 Angell-Shiley valves (16.2 +/- 8.6 ds) and 9 Carpentier-Edwards valves (14.4 +/- 3.7 ds). IBA showed a tendency to have large valve in the heart with small left ventricular end-systolic volume. The results showed that stent creeping phenomenon was not related to the material or design of stent-post, but tended to increase with passage of time in place. Furthermore, it was suggested that stent creep was induced by the mechanism of compression of the stent by the left ventricular wall.

Adult↗
PubMed1988

[A clinical study of severe cases of hemorrhagic cerebral arteriovenous malformations].

The clinical study was undertaken on 24 poor risk patients out of 69 cases with hemorrhagic cerebral arteriovenous malformations, AVMs, and the surgical problems of poor risk patients with the lesions were discussed. The 24 cases, 35%, out of 69 hemorrhagic AVMs cases showed disturbances of consciousness of 3 digits (100-300) according to the Japan Coma Scale at the time of admission. All cases of these poor risk patients were observed less than 24 hours after the onset of the symptoms. Fifteen of these 24 cases showed brainstem signs including anisocoria and/or decerebrate rigidity and/or respiratory arrest. Eighty-three per cent of 24 poor risk patients had serious neurological defects as a result of the first hemorrhage. Therefore, it was impossible to prevent serious state from occurring in poor risk patients. Of the 69 cases with hemorrhagic AVMs, 56 cases were operated upon. Although 90% out of 38 good risk patients whose level of consciousness was 0 to 30 according to the Japan Coma Scale showed good recovery, only 44% of 18 poor risk patients recovered well. It could not be said that the surgical treatment gave satisfactory results for the poor risk patients when compared with the surgical results of the good risk patients. In respect to the location of AVMs, all three poor risk patients with AVMs in the corpus callosum and the ventricles showed good recovery, whereas of the poor risk patients with AVMs in the cerebrum or the cerebellum, only 4 out of 9 cases (44%) and 1 out of 6 cases (17%) showed good recovery respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1988

[Origin of the capsule of a chronic subdural hematoma--an electron microscopy study].

To understand the early stage of subdural neomembrane (SN) formation, we examined 23 outer SNs and two inner SNs of chronic subdural hematomas in surgical specimens. Ultrastructurally, the cellular component of the outer SN was fibroblasts, myofibroblasts, smooth-muscle cells (in four cases), blood vessels and blood-born cells. Dural border cells were observed only in limited areas. Namely, the outer SN is a simple granulation tissue which originates from multiple sources of mesenchymal cells in dura mater, and dural border cells are only one of constituent sources for SN formation. The inner SN was simply composed of slender spindle cells which were mostly fibroblasts and some were recognized as dural border cells. Our results showed that the subdural hematoma is actually an "intra" dural hematoma which is formed within the split dural border cell layer. The dura mater with rich vascular supply forms thick granulation tissue, that is outer SN and a few dural border cells on the underlying arachnoid membrane form thin fibrous inner SN.

Adolescent↗
PubMed1988

[Surgical treatment of esophageal cancer and gastric cancer in relation to a questionnaire on the daily lives of the patients].

A questionnaire on the daily life was mailed to patients who had undergone esophagectomy and retrosternal esophagogastrostomy. Replies came from 29 patients. Employment of the patients was 66%. However 97% of the patients could go out and enjoy their own ordinary lives. Replies of questionnaires came from 66 patients aged 70 and over who had undergone gastrectomy. Employment of the patients who had worked before operation, was decreased, 60%. However, 88% of the patients could go out and enjoy their own ordinary lives.

Employment↗
PubMed1987

Heterogeneity of reducing terminals of urinary chondroitin sulfates.

Human urinary chondroitin sulfates were isolated by precipitation with cetylpyridinium chloride of the non-dialyzable fraction of pooled urine, followed by ethanol fractionation and successive enzymic digestions with neuraminidase and mucopolysaccharides. Further purification was achieved by Dowex-1 chromatography with stepwise elution by increasing the concentration of NaCl at intervals of 0.25 M from 0.75 M to 1.5 M. The chondroitin sulfates thus obtained were characterized by the analysis and quantification on of carbohydrate, amino acid and sulfate, and by electrophoresis on cellulose acetate membrane. Then reducing terminals were identified by gas liquid chromatographic analyses of the acetyl and butaneboronate derivatives of hydrolysates, after reduction of the reducing terminals with sodium borohydride. About 22.8% of the urinary chondroitin sulfate in the 1.5 M fraction was peptide-bound, and the remainder was peptide-free, with xylose (29.8%), galactose (23.6%) and glucuronic acid (18.7%) at the reducing terminal. The amount of peptide-free chondroitin sulfate with xylose and galactose at its reducing terminals in the 0.75 M-, 1.0 M-, 1.25 M- and 1.5 M-fractions increased in the order described in parallel with the increase of sulfation and the decrease of peptide content. It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.

Amino Acids↗
PubMed1987

Contractile proteins: possible targets for the cardiotonic action of MCI-154, a novel cardiotonic agent?

The effect on the contractile protein system of MCI-154, a novel and potent cardiotonic agent, was examined by using thin bundles of chemically skinned fibers from the guinea-pig papillary muscles. MCI-154 increased the Ca2+ sensitivity of the contractile protein system of the cardiac skinned fibers. Moreover, MCI-154 enhanced the maximum tension developed at pCa 4.4. These results suggest that an increase in responses of the contractile protein system to Ca2+ ion is, at least in part, responsible for the positive inotropic action of MCI-154.

Animals↗
PubMed1987

Popliteal vein entrapment caused by the third head of the gastrocnemius muscle.

Three cases of the popliteal vein entrapment syndrome have been encountered during the past 3 years. The third head of the gastrocnemius muscle appeared to be the cause of this rare condition with the vessels in their normal position. Partial resection of the excess muscle was sufficient to relieve symptoms.

Adolescent↗