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Biomedical subjects

M Elton

Publications and source records attributed to M Elton.

34 records · Page 2Linked to original sources

Anorexia nervosa in Greek and Turkish adolescents.

Five samples of adolescents were assessed in three countries: (1) 867 Greek pupils in Munich (Germany), (2) 2,700 Greek pupils in Veria (Greece), (3) 567 girls in Ioannina (Greece), (4) 2,783 adolescents in Istanbul (Turkey), and (5) 157 adolescents in Upper Bavaria (Germany). A two-stage procedure was used for samples one, two and four using the Anorexia Nervosa Inventory for Self-rating (ANIS) for screening and a standardized interview (Structured Interview for Anorexia Nervosa and Bulimia) for personal exploration of possible cases and final case identification. Results of all samples were compared. Greek girls in Germany scored higher than Greek boys in Germany and Greek boys and girls in Germany scored lower than Greek girls in Veria in the ANIS factors figure consciousness, insufficiency, anancasm, negative effect of meals and bulimia in practically all age groups. The frequency distribution of the ANIS main factor figure consciousness was the same for both Greek samples in Greece, while the Turkish sample and the Greek sample in Munich had significantly lower scores. In the second stage the prevalence rates for anorexia nervosa according to Feighner criteria (modified for the purpose of a field study) were: 1.10% for Greek girls in Munich, 0.41% for Greek girls in Veria and 0.35% for Greeks in Ioannina. Thus, while Greek girls in Germany had lower scores in ANIS factors and other self-ratings (General Health Questionnaire) the actual rate of anorexic syndromes was highest among Greek girls in Munich. Socio-cultural influences and selection factors are discussed.

Adolescent↗

Mental illness in Greek and Turkish adolescents.

Samples of 867 Greek adolescents in Munich, 2,702 Greek adolescents in Greece and 2,780 Turkish adolescents in Turkey were assessed concerning mental health in a two-stage procedure. In the first stage the General Health Questionnaire (GHQ) was used for screening. Significant age differences in the GHQ 28-item scale and most of its subscales were observed mainly for the samples in the homeland. Male adolescents had lower scores than female adolescents in the GHQ 28-item scale and its sub-scales while social class appeared to be of little influence. Significantly higher GHQ-28 scores were obtained for Greeks and Turks in their homeland as compared to Greeks in Turks in their homeland as compared to Greeks in Munich. The GHQ-28 correlations with the Anorexia Nervosa Inventory for Self-Rating were fairly high. A principal component analysis with Varimax rotation showed fairly consistent results for this age group when compared with the results of Goldberg and Hillier (1979). With the exception of the GHQ factor social dysfunction Greek adolescents in their homeland had significantly higher scores in the total GHQ-28 and its sub-scales than Greeks in Germany. Thus, our data do not confirm the acculturation-stress hypothesis. The data would be consistent with the hypothesis of selective migration which states that Greek adolescents in Germany constitute a positive selection with respect to risk for mental illness.

Acculturation↗

A comparative investigation of the principal component structure of the 28 item version of the General Health Questionnaire (GHQ). 15-year-old schoolgirls in England, Greece, Turkey and West Germany.

The 28-item version of the General Health Questionnaire of 15-year-old schoolgirls obtained under identical conditions in two separate studies was subjected to principal component analysis (PCA). Varimax rotation produced different numbers of components for the different groups, but restricting the number of components to be rotated to four produced similar component structures, as supported by the coefficient of factor similarity, for both Turkish and Greek groups in their home countries and a heterogeneous non-British group in London in comparison to British girls. Different structures were obtained in schoolgirls from Greece, in Munich, and from the Indian subcontinent in London. Analysis of variance of the factor scores of a combined PCA produced significant overall group differences for all components and specific group differences for anxiety and insomnia, social dysfunction, and severe depression. Somatic symptoms and anxiety and insomnia subscales, either alone or in combination with other subscales, contributed most frequently to morbidity.

Adolescent↗

The principal component structure of the General Health Questionnaire among Greek and Turkish adolescents.

The 28-item version of the General Health Questionnaire was administered to Greek and Turkish school pupils in their mother country as well as to Greeks in Munich. Principal component analysis with varimax rotation was carried out separately for both the individual populations and sexes separately. Visual inspection of the matrices suggested overall agreement with the sub-scales obtained by Goldberg and Hillier (1979). The coefficient of factor similarity, calculated between matrices, suggested a highly similar principal component structure between the population samples as a whole and separately for the sexes living in their own country, but not between male and female Greek pupils in Germany. Highly similar component matrices were obtained for Greek males living in Greece with those in Germany, but not for females.

Adolescent↗

P3b peak latency dependency on the point of information delivery within a stimulus.

An acoustic matching experiment was conducted consisting of three quasirandom conditions in which the sequence of tones comprising the second stimulus was changed at the beginning, at the end, or not at all. Latency of maximum positivity (P3b) was measured for each subject between Pz and the averaged mastoids. Evaluation of mismatch conditions demonstrated that peak latency depended on the point of information delivery within the stimulus. Further, peak latency within both mismatch conditions, when adjusted for the timing of tone sequence change, was approximately equally delayed in comparison to match. The implications of the results for information processing models of attention are discussed.

Acoustic Stimulation↗

Brain-stem auditory-evoked potentials in post-comatose patients after severe closed head trauma.

Brain-stem auditory-evoked potentials (BAEPs) were recorded in 35 post-comatose patients after severe closed head trauma. Compared to the normal BAEPs obtained from 30 normal controls, significant individual abnormality could be detected in only 2 patients. This abnormality consisted of lateral asymmetry, but not prolonged interpeak latencies or abnormal amplitude ratios. Further, no differences were found between groups as regards interpeak latencies. A significant reduction of BAEP amplitudes was seen in the patient group, being most pronounced in the 13 patients with hearing loss. It is concluded that the BAEP does not sufficiently reveal brain-stem lesions expected to persist after severe closed head trauma, presumably because the structures generating waves IV and V are not permanently affected. The amplitude reductions observed may be explained by the diffuse cochlear damage known to occur concurrently with head trauma.

Adolescent↗

Effects of high-pass filter frequency and slope on BAEP amplitude, latency and wave form.

The effects of increases in analogue high-pass filter frequency and slope on the BAEP were investigated in a group of 20 subjects. Frequency effects were additionally compared to the wide-band recorded signal and slope effects to a zero-phase shift filter, all filters being digitally simulated. Absolute amplitude, latency and interpeak latency were significantly reduced by both progressive filter frequency and steepness. Additionally, different effects on the ascending and descending limbs of waves I, III and V were observed which explain wave form distortions. The results suggest that filtering should be limited to, at most, 6 dB/oct and 100 Hz frequency.

Adult↗

A longitudinal investigation of event-related potentials in depression.

A longitudinal investigation of the evoked potential to a warning stimulus, and of the CNV, was conducted with reactive depressives and controls under incentive and nonincentive conditions in a long interstimulus interval paradigm. A smaller group of endogenous depressives were recorded once. The application of multivariate analysis, which controlled for experimental and session effects, indicated that the CNV, as a multiple-component potential, is not capable of distinguishing reactive depressives from controls. Significant univariate interactions involving late CNV area and peak latency were obtained, possibly indexing psychomotor retardation. Analysis of the evoked potential did reveal significant group differences which were explained in terms of main and interaction effects in the P240 and interaction effects involving N120. The findings suggested that groups differed in their responsiveness to experimental demands, and modified their responses differently over time. Mann-Whitney U analysis of endogenous depressives produced no group differences in the CNV measures, but did for N120 amplitude.

Acoustic Stimulation↗

Predictors of the outcome of disability pension for alcohol abusers.

A multi-variate multiple regression analysis was carried out to screen the crucial characteristics of alcohol abusers immediately prior to pension in order to indicate their subsequent trends. Stepwise multiple regression analyses were performed in the younger and older subgroups, as well as in 56 first-time pension applicants, in a region of the county of Ostergötland in Sweden. In the analyses, changes, over a 2-year interval, of composite scores on overall well-being, psychiatric status, need satisfaction and intellectual capacity, together with changes in alcohol consumption and gamma-GT-value, functioned as dependent variables. Eighty-five parameters of the abusers' quality of life at pension served as independent variables. The features that were seen, in various constellations, to be significantly related to non-improvement rather than to improvement were: an abrupt change-over from a previously active life, longer education, middle age, tendencies to passivity and to social confinement, worse observed psychiatric status in contrast to less bad reported status, relatively better self-rated well-being, remaining intellectual resources, black-outs, a lower current alcohol consumption, lower gamma-GT, S-NAP, S-ALAT- and S-protein-values together with more elevated P-IgA, P-ALP-, S-creatinine- and S-Ca-corrected values. The results are discussed with reference to their general applicability, plausible mechanisms in a pension situation, previously launched hypotheses, and the methodological limitations of the study. It is concluded that a literal application of the results in practice must be made with caution.

Adult↗

Do brain damage and liver disease interrelate in advanced abusers of alcohol?

In a consecutive material comprising 43 alcoholics immediately prior to pension, due to their abuse, the interrelations between different symptoms of dysfunction of the brain and liver were studied. Signs of brain damage used were: psychometric test, delirium tremens and withdrawal seizures. Liver disease was examined by biopsy and liver function tests. The signs of dysfunction were compared with drinking pattern, amount of alcohol consumption and duration of abuse. The group was fairly homogeneous with respect to these variables. The patients showed a considerable degree of brain and liver damage, but relevant significant correlations between the criteria of brain and liver disease could not be demonstrated. This may support the hypothesis that the brain and the liver, in the same individual, react differently to alcohol.

Alcohol Drinking↗

Abusers of alcohol immediately prior to pension.

In the granting of a disability pension to an alcohol abuser society is taking a somewhat controversial step. In order to elucidate the overall situation of these abusers, the quality of life of 61 abusing applicants was examined. The sample represents all 78 first-time applicants during an 18-month period in a geographically defined region in the county of Ostergötland in Sweden. As expected, apart from their extensive abuse, the applicants were in bad psychiatric-psychological condition and demonstrated severe neuro-psychological and biochemical disturbances. In addition, their social network was somewhat restricted and also otherwise rather problematic. These deviations were evident in relation to a matched group of newly pensioned non-abusers. In comparison with another more closely matched group of abusers undergoing rehabilitation, the differences appeared mainly within the psychiatric-psychological sphere. This is a report in a series from the research project "Abuse of alcohol - Disability pension - Quality of life".

Alcohol Drinking↗

Grounds for disability pension. The younger abuser as compared with older abusers of alcohol.

Current social legislation in Sweden prescribes a great degree of restrictivity in the granting of disability pensions to young abusers of alcohol. In order to test whether this prescription is really applied, a comparison between 29 abuser applicants up to age 46 and 32 and over the age of 46 years was carried out. The total of 61 abusers represented all 78 first-time applicants with an abuse over a period of 1 1/2 years who were living in a geographically defined, mixed urban-rural region in the Swedish county of Ostergötland. The period lasted from 1st January 1978 until 1st July 1979. The participants' quality of life was examined in a multidisciplinary fashion. In line with the prescribed restrictivity, the younger group proved to be fundamentally worse, primarily in socio-psychological and psychiatric respects. In addition, they also demonstrated a greater degree of alcohol injury. Besides the legislative situation, even situational conditions were proposed as explanatory factors for the empirical findings. This is the fourth report from the research project "Abuse of alcohol - Disability pension - Quality of life".

Age Factors↗

A comparative investigation of ERP components and the SCR in a habituation and dishabituation paradigm.

The present experiment investigated the trial-by-trial habituation in the event-related potential (ERP) and the skin conductance response (SCR) to repeated stimuli and dishabituation to rare stimuli. In a balanced design, two groups of subjects passively observed either large black discs as repeated stimuli and small as rare, or vice versa. No consistent effects of stimulus size were obtained between the groups. Late positivity was composed of a double peak at Cz, containing contributions from P3a and P300; the latter only was observed at Pz. The SCR and P3a and P300 at Cz demonstrated habituation, but not the N100 or P200, nor the P300 at Pz. Rare stimuli elicited an enhancement, albeit nonsignificant, in SCR amplitude only. No dishabituation of any of the responses by these stimuli was observed. The SCR correlated significantly with late positivity at Cz and Pz. Discussion focuses on SCR and late positivity as OR components.

Acoustic Stimulation↗

A prospective longitudinal study of abusers of alcohol granted disability pension.

The present study was carried out to obtain a better conception of the consequences of disability pension for abusers of alcohol. A total of 78 abusers applied for disability pension during 1 1/2 years in one specific region of the Swedish county of Ostergötland. Fifty-six of 61 individuals who could be contacted and who were examined immediately before they were pensioned, could also be re-examined after 2 years. Two minor matched reference groups, newly pensioned non-abusers and abusers undergoing rehabilitation, were also examined in almost an identical way with a 2-year interval. In contrast to common expectations, the pensioned abusers demonstrated positive changes in their reported abuse, psychiatric status, self-rated well-being, nutritional status and mental test performance, as regards perceptual analysis and figurative memory. Their social and structural situation as well as their daily activities were fairly constant. The results are discussed particularly with regard to the selection of examination occasions, the international evaluational research on treatment for alcoholics and the course of alcoholism. It is advocated that the results should be interpreted with caution and not taken as indications for granting pensions to an even greater extent. However, it can be concluded that the examined pensioned abusers showed improvement rather than impairment. This is the fifth report in a series from the research project "Abuse of alcohol - Disability pension - Quality of life".

Activities of Daily Living↗