The mechanism of the rhythmic changes in the calibre of the bronchi during respiration.
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Biomedical subjects
Publications and source records attributed to M Ellis.
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Zelinsky and Lee recently unveiled a model of the sociospatial process of immigrant settlement designed to augment and possibly supplant the well-known theories of assimilation and pluralism. Although in some ways new, their work continues a tradition in social science that treats the settlement geography of immigrants as a measure of their more general fit into American society. The authors question the prevailing assumption that immigrant settlement patterns represent a barometer of their adaptation, or lack thereof, to a host society. This critique of the concepts of assimilation, pluralism and Zelinsky and Lee's alternative "heterolocal" model of immigrant settlement pivots around the issues of spatial scale and race. The authors argue that the contestations over immigration and how well immigrants fit into society are increasingly constructed at the regional scale. The authors also assert that questions race infuse almost all aspects of these debates. The transformation of America's largest city-regions into places of non-White immigrants, and the shifting political balance of power to states like California through immigration-driven reapportionment, are touchstones for anti-immigration initiatives and associated local and national debate. Fear of racial regional changes underpins an increasingly powerful response to immigration. The reactions elicited by these settlement geographies fall under the heading the authors call the "territorial politics of immigration".
Homocystinuria due to cystathionine beta-synthase deficiency was excluded in a fetus at 23 weeks' gestation by demonstrating activity of the enzyme in fetal lymphocytes after stimulation by phytohaemagglutinin. Fetal blood sampling was carried out because two determinations of enzyme activity on cultured amniotic cells gave low, not fully diagnostic values.
Acute hypercalcemia in the conscious, unanesthetized rat, achieved by a 30-minute infusion of CaCl2 (serum calcium level, 12.8 +/- 0.6 mg/dl) resulted in significant elevation of mean arterial pressure (from 112 +/- 2 mm Hg to 129 +/- 3 mm Hg, p less than 0.001). This pressor response was associated with a significant increase in systemic vascular resistance, from 0.45 +/- 0.02 mm Hg/(ml/min)/kg body weight to 0.50 +/- 0.02 mm Hg/(ml/min)/kg body weight (p less than 0.05), but it caused no alteration in cardiac index. The pressor response to acute hypercalcemia does not appear to be mediated by vasopressor hormones or attenuated by vasodepressor hormones since inhibition of the renin-angiotensin system (nephrectomy), catecholamines (central and peripheral 6-hydroxydopamine), vasopressin (vascular antagonist), prostaglandins (indomethacin), and parathyroid hormone (parathyroidectomy) did not significantly alter the pressor response to infusion of CaCl2 in spite of similar serum calcium levels in all groups of animals. Rather, the pressor response to acute hypercalcemia seems to be mediated by a direct action of calcium ion on smooth muscle and perhaps myocardial cell contractility, since pretreatment with the calcium channel blockers verapamil or nifedipine blocked the pressor response to acute hypercalcemia.
In an effort to evaluate conformity with published guidelines for diagnostic allergy skin testing in their locality, a committee of members of the Orange County (California) Society of Allergy and Clinical Immunology surveyed their membership for the number, identity, and rates of sensitization of aeroallergens in a selected patient population. Test data were analyzed on patients who were judged appropriate to undergo immunotherapy. Complete test results of 271 patients were obtained from one third of local allergy specialists. A total of 115 different aeroallergen extracts were identified. By category, tree pollen allergens (32) were followed in declining order by weed pollens (28), molds (22), environmentals (18), and grass pollen extracts (15), for the total of 115. The average number of aeroallergens used by a practice in a comprehensive evaluation was 77 (range, 47-114). When only unequivocally positive reactions were considered (3+ equivalent or greater), Bermuda grass pollen extracts elicited the highest rate, 85%, and the environmental, rat dander, was the lowest at 1.8%. At least 20% of the patients reacted strongly on skin tests to 97% of the extracts. The disparity between the recommendations of a maximum of 30 aeroallergens for a comprehensive evaluation and actual practice procedures merits efforts at resolution.
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