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Biomedical subjects

M Elliott

Publications and source records attributed to M Elliott.

At least 163 records · Page 9Linked to original sources
PubMed1980

In vitro augmentation of cytotoxicity against tumor cell lines by mumps virus.

Cultures of leukocytes from normal subjects and bladder and kidney cancer patients contain cells cytotoxic against various tissue culture human cell lines. Postculture cytotoxicity was increased, in some experiments, after cocultivation with an inactivated strain of mumps virus. Effector cells seem to have an Fc receptor inasmuch as the activity was removed by absorption on immoblized antigen-antibody complexes.

Adenocarcinoma↗
PubMed1980

Attenuation of I- 125 radiation by chloroform and other dense solvents, and its relevance to radioimmunoassays: concise communication.

The counting efficiency of iodine- 125 in well-type scintillation counters is reduced when the labeled compound is dissolved or suspended in chlorinated hydrocarbons or potassium iodide solution. The reduction is probably caused by absorption of the weak gamma and x-rays of I- 125 by the halogen atoms in the solvent or solute molecules. This phenomenon may introduce artifacts into procedures involving radioiodinated compounds and organic solvents and KI, but it could also be useful in differentiating bound from free labeled ligands by their differential solubility (and attenuation) in dense solvents. The reduction in counting efficiency can be overcome by evaporation of the solvent, or by the use of emitters with higher energy radiation.

Cardiolipins↗
PubMed1979

[Thrombocyte function and systemic effect of prostaglandin I2 inhalation].

After inhalation of prostaglandin I2 minimal effects on lung function and the cardiovascular system could be observed in healthy volunteers. Platelet function, however, decreased significantly. In the future the application of the prostaglandin I2 may be a new approach in the treatment of thromboembolic disorders in man.

Adult↗
PubMed1976

Histoplasmosis: an outbreak occurring among young men who visited one cave.

Sixteen cases of acute benign inhalational histoplasmosis were investigated after an outbreak of the disease in a group visiting a cave. The diagnosis was confirmed in 13 patients by chest X-ray examination, histoplasmin skin testing and serological examination. An attempt to isolate the organism Histoplasma capsulatum was unsuccessful. The epidemiology and relationship of the disease to bat ecology is discussed.

Animals↗
PubMed1976

Maternal factors associated with fetal chromosomal anomalies in spontaneous abortions.

The effect is described of maternal factors on the proportion of fetal chromosomal anomalies in a series of 2620 spontaneous abortions, of which 992 specimens were karyotyped. Maternal age was the most important factor associated with a rise in the proportion abnormal, followed by Social Class I or II and the use of oral contraception before conception. The problem of extrapolating from the proportion abnormal to absolute incidence of anomalies is discussed. In the case of increasing maternal age, the evidence suggests that the rise in incidence of spontaneous abortions with age is accounted for by an increased incidence of chromosomally abnormal fetuses. In the case of high social class and a history of oral contraception, the evidence on incidence is scanty and the rise in the proportion abnormal may either reflect a decrease in the abortion rate of chromosomally normal fetuses, or a small increase in the incidence of lethal chromosomal anomalies.

Abortion, Spontaneous↗
PubMed1976

Properties and applications of pyrethroids.

Improved understanding of the factors determining the insecticidal activity, the mammalian toxicity, and the stability in air and light of natural and synthetic pyrethroids has led to a series of new compounds with a very favorable combination of properties. Their characteristics include outstanding potency to insects, low toxicity to mammals associated with rapid metabolic breakdown and, in appropriate cases, adequate stability on plant surfaces even in bright sunlight. Initial tests indicate that even the more stable compounds are degraded rapidly in soil, so if the trials at present in progress reveal no toxicological or environmental hazards, within a few years synthetic pyrethroids should be available to control a wide range of domestic, veterinary, horticultural, agricultural, and forest pests at low rates of application.

Animals↗
PubMed1975

Previous reproductive history in mothers presenting with spontaneous abortions.

Information on the previous reproductive history of 3467 mothers presenting with a spontaneous abortion is compared with that of a control series presenting with a livebirth. In 1384 abortions the chromosome constitution of the fetal products was determined. The mothers who had delivered a chromosomally normal abortion more often had a history of previous repeated abortions, while those of chromosomally abnormal abortions tended to have fewer repeated abortions but an excess of previous viable children with Down's syndrome. Data are also presented on 23 mothers with two spontaneous abortions of known karyotype; these, together with similar data obtained elsewhere, made it possible to estimate an overall rate of recurrence of chromosome defects in conceptions of the same parents, and the probability that affected fetuses will survive to a viable stage in pregnancy. The clinical and genetic implications of the findings are briefly discussed.

Abortion, Habitual↗
PubMed1971

The relationship between the structure and the activity of pyrethroids.

There is considerable scope for developing new non-persistent insecticides with little hazard for man and mammals by modifying the structures of the natural pyrethrins. New compounds already synthesized are more effective against some insect species than are the natural compounds, are even less hazardous to mammals, and do not need synergists to supplement their insecticidal action. Other examples show considerable insect species specificity. These compounds may help to control insect vectors when other insecticides are no longer effective because resistance has developed or because their residues can no longer be tolerated.

Animals↗