Search PubMed⌕ Search

Biomedical subjects

M Elkin

Publications and source records attributed to M Elkin.

At least 37 records · Page 2Linked to original sources
PubMed1994

Relaxation of imprinting in trophoblastic disease.

Genomic imprinting--the uniparental-dependent transmittance of a genetic trait--has been accepted in recent years as a major mechanism in mammalian genetics. We studied the expression of the H19 gene, a parentally imprinted (maternally expressed) gene, by in situ hybridization in human placenta and trophoblastic disease. Expression was found to be abundant, in a decreasing order, in the intermediate trophoblast (villous and interstitial), the cytotrophoblast, and the syncytiotrophoblast. The villous stroma was also prominently labeled. Partial hydatidiform mole showed a similar pattern of expression as normal placenta. As expected, complete hydatidiform mole, whose genome consists of two haploid sets of paternal origin, was not labeled in the villous stroma and surrounding trophoblastic layer. However, some of the large mononuclear cells in the proliferating groups sprouting from the villous surface were strongly labeled. Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma. The phenomenon of emergence of expression of alleles subject to repression according to their gamete of origin is termed relaxation of imprinting, and is considered to be relevant to tumorigenesis. We suggest that the expression of the maternally expressed H19 gene in the androgenetic tissue of complete hydatidiform mole represents relaxation of imprinting and may be associated with its malignant potential.

Choriocarcinoma↗
PubMed1990

Stages in the growth of uroradiology.

For much of its history, uroradiology was dominated by the urologists. At the birth of the Radiological Society of North America, retrograde pyelography was well established. The major actors in the discovery of intravenous urography were urologists. Despite the availability of urography, the preeminence of retrograde pyelography was initially maintained because of its superior demonstration of the pelvicalyceal system. Selective renal angiography, high-dose intravenous urography, and nephrotomography provided excellent radiologic means for study of the renal parenchyma and put radiologists firmly in charge of uroradiology, a position further strengthened by the advent of ultrasonography and computed tomography.

Angiography↗
PubMed1976

Enzymatic evidence of renal tubular damage following renal angiography.

Ligandin, a glutathione (GSH) transferase, is a protein found in proximal tubular cells as well as in other tissues. It does not occur in the urine of normal subjects; however, its presence has been detected in the urine of some patients who have undergone renal angiography. This finding suggests renal tubular cell damage due to the procedure.

Acute Kidney Injury↗
PubMed1976

Epinephrine in the angiographic evaluation of experimental kidney trauma.

Selective nephroangiography was performed in the dog following percutaneous needle biopsy to evaluate epinephrine response. Traumatized vessels respond normally to epinephrine, often with increased extravasation as the vessel recovers from epinephrine. A selective inability of the traumatized vessel to constrict was not noted.

Animals↗
PubMed1975

Radiology of the urinary tract: some physiological considerations. Annual oration in memory of John S. Bouslog, M.D., 1890-1973.

This paper reviews some of the fundamental technical and diagnostic problems in clinical uroradiology, such as (a) the reason for the obstructive nephrogram; (b) why high-dose urography gives better studies than low-dose; (c) why the Trueta phenomenon has not been demonstrated in man; (d) the case for an intrarenal arterial collateral pathway via the pericalyceal network (these vessels can be demonstrated in man and must not be misinterpreted as tumor vessels or vascular malformations). One of the most baffling problems sometimes occurs with the sudden partial block of a single segmental vessel: the kidney ceases to excrete urine and eventually becomes atrophic even though some excretory function returns. To date, there is no satisfactory explanation for this course of events.

Adult↗