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Biomedical subjects

M Edwards

Publications and source records attributed to M Edwards.

At least 253 records · Page 14Linked to original sources
PubMedDate not supplied

MRI and cerebral venous thrombosis.

Difficulties in the diagnosis of cerebral thrombosis are due to the nonspecificity of symptoms and signs and the infrequent occurrence on computed tomography (CT) of direct signs of cerebral sinus thrombosis, i.e. the empty delta sign and cord sign. We present two patients, a 2 4/12-year-old girl with nephrotic syndrome, coma, papilledema, and hyperdensity along the sagittal sinus on CT; and a 34-year-old man with headaches, episodic visual loss, papilledema and a normal CT following posterior fossa craniotomy. On MRI, there was increased signal in sagittal and straight sinuses in the first patient, and in the lateral sinus in the second patient. The increased signal from clot, and the absence of signal from flowing blood, make MRI the procedure of choice for the initial diagnosis of cerebral sinus thrombosis.

Adult↗
PubMedDate not supplied

Deletion of the dystrophin muscle promoter in feline muscular dystrophy.

We have characterized the mutation in a feline model of DMD that selectively eliminates expression of the muscle and Purkinje neuronal dystrophin isoforms. The cortical neuronal isoform was expressed at a detectable level in skeletal muscle in the absence of the muscle promoter and levels of PCR products representing cortical neuronal-type transcripts in dystrophic muscle were comparable to those of normal feline skeletal muscle. Although localized at the sarcolemma, cortical neuronal dystrophin apparently failed to protect skeletal muscle. Neuronal transcripts could not be amplified from feline heart, indicating that these promoters are not active in this tissue in the cat.

Animals↗
PubMedDate not supplied

Patterns of referral for children with speech disorders.

This paper presents information about a sample of 200 children aged 3-6 years in four Health Authorities. They were referred routinely for speech therapy. Age of referral, distribution within the family, sex and sources of referral are indicated and discussed.

Birth Order↗
PubMedDate not supplied

A computed tomography-radiation therapy treatment planning system utilizing a whole body CT scanner.

An external beam radiation therapy treatment planning system has been developed to run on the GE CT/T whole body scanner. The system interactively obtains treatment planning information directly from CT scans, including relative density conversion of user input inhomogeneity regions. The program generates beams isodose tables from input TAR-SAR data using the Cunningham model. Inhomogeneity corrections are applied using the power law TAR method at low energies and the TAR ratio method at high energies. Beam data are generated on the central axis and at off-axis locations coplanar with each CT scan, and isodose distributions are displayed on any transverse, coronal or sagittal plane. Examples of plans and initial verification results are discussed.

Computers↗
PubMedDate not supplied

Barriers to effective pain/symptom control.

We have a challenging call to provide compassionate care and comfort in a changing and varied clinical, social and financial setting. Multiple variables including race, creed, age, and sex of the patient can impact the decision-making process. It is hoped that consideration by professional caregivers of the above barriers will improve and provide consistent care to those put in our charge.

Analgesics↗
PubMedDate not supplied

Computers in radiology. Interfacing with peripheral devices.

A fundamental part of building a computer system is control of and communication with peripheral devices. With use of graphics display terminals, video image digitizers, and array processors as examples, the basics of peripherals are discussed as they affect radiologic applications.

Computers↗
PubMedDate not supplied

Safety, permanency, and in-home services: applying administrative data.

This article describes the construction and use of safety and permanency indicators, two aspects of a full set of indicators that also includes child well-being and family functioning. The indicators were constructed from Philadelphia's Family and Child Tracking System and were used to examine the city's Services to Children in their Own Home (SCOH) program. Cohort datasets were constructed through the use of extract files, and two independent data file construction algorithms were employed to calibrate the accuracy of the data construction process. The primary unit of analysis was the "family" spell in SCOH services. Contextual variables included family structure, race, and service intensity. The indicators associated with SCOH spells included reports of maltreatment after service, founded maltreatment after service, and out-of-home placement after service. Event history techniques were used to conduct the data analysis. Baseline indicator data for Philadelphia are presented, and future uses for such data are discussed.

Child↗