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Biomedical subjects

M Edmonds

Publications and source records attributed to M Edmonds.

68 records · Page 4Linked to original sources
PubMed1972

Polyadenylic acid sequences in the virion RNA of poliovirus and Eastern Equine Encephalitis virus.

Poliovirus virion RNA contains a single covalently bound sequence of polyadenylic acid which is approximately 49 nucleotides long. A single, slightly longer polyadenylic acid sequence is contained in Eastern Equine Encephalitis virus RNA. Since these viruses are otherwise dissimilar these sequences may play a common role in viral replication, possibly in translation of the viral RNA.

Adenine Nucleotides↗
PubMed1971

Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship.

Polyadenylate sequences have been found covalently linked in heterogeneous DNA-like nuclear RNA of HeLa cells. This poly(A) material seems homogeneous in size and accounts for about 0.5% of such RNA. Similar poly(A) sequences were found in rapidly-labeled polyribosomal RNA, thought to be messenger RNA. A possible model for mRNA synthesis from large heterogeneous nuclear RNA precursor molecules is discussed.

Adenine Nucleotides↗
PubMedDate not supplied

New treatments in ulcer healing and wound infection.

This review examines several of the recently introduced wound care products that have been put forward as treatment modalities for the diabetic foot ulcer. Discussed are the results of clinical trials with the platelet-derived growth factor, becaplermin, the tissue-engineered products Dermagraft and Apligraf, and Hyaff which is an ester of hyaluronic acid. In patients with an infected foot ulcer, encouraging results were obtained with the granulocyte-colony stimulating factor, Filgrastim.

Becaplermin↗
PubMedDate not supplied

The effect of regular callus removal on foot pressures.

The optimum frequency of callus removal is unknown. This study shows that in-shoe dynamic plantar pressure measurement can quantify the effect of callus removal in relation with the frequency of podiatric treatment in diabetic ulcer patients. Three groups of diabetic neuropathic patients were studied. Group 0 consisted of six patients who presented for the first time ever for callus removal and who did not have a history of ulceration. The other two groups had a history of ulceration and required regular podiatry treatment: every 6-8 weeks for 10 patients in group A, and every 3-4 weeks for eight patients in group B. Peak plantar pressures were measured using the F-SCAN system, before and after removal of callus, which was weighed to further quantify the effect of podiatry. When callus was removed, peak pressures fell by 32.1 +/- 8.4% (p = .014) in group 0, by 30.9 +/- 4.5% (p < .005) in group A, and by 24.8 +/- 4.0% (p = .005) in group B. The mean weight of callus removed was not significantly different in the three groups. This suggests that the weight of callus is unlikely to be a reliable guide to assess the time intervals between podiatry appointments. However, the measurement of plantar pressures using a dynamic in-shoe plantar pressure device has proven to be a functional, objective, and quantifiable indicator in the assessment of podiatric treatment.

Adult↗
PubMedDate not supplied

Using the Vista 350 telephone to communicate the results of home monitoring of diabetes mellitus to a central database and to provide feedback.

PURPOSE: Self-monitoring of blood glucose has become routine practice in the management of diabetes mellitus. When all the data is complete, however, the amount of information to be taken into account when making therapeutic decisions becomes overwhelming not only for the patient but for the healthcare provider. Computers excel at processing large amounts of information quickly and impassively, which makes them potentially helpful for collating and communicating the data in a manner that facilitates decision-making by patient and healthcare provider. This should in turn improve control and help prevent acute and chronic complications. METHOD: Using the Vista 350 telephone, we have developed a system that enables patients with diabetes to record home monitoring data to a central database and receive feedback summaries. A small trial was conducted to determine if the Vista 350 telephone is an acceptable and feasible method to communicate the results of home monitoring of diabetes mellitus to a central database and receive feedback summaries. A total of 35 volunteers with insulin-requiring diabetes mellitus in the London area were randomly allocated to either use the Vista 350 phone for 6 months, or to a control group that continued to use traditional methods for recording home monitoring data. RESULTS: 33 of the 35 patients enrolled completed the trial. All 16 patients who began using the phone continued to do so for 6 months confirming the feasibility of the system. Questionnaires completed at 3 and 6 months confirmed the Vista 350 telephone system to be acceptable to the subjects. The results will enable some minor modifications to be made to the telephone system before a larger definitive trial, designed to determine the effect on diabetes control, is conducted later this year.

Blood Glucose Self-Monitoring↗
PubMedDate not supplied

Diabetic foot ulcers.

Nurses caring for people with diabetes can have an impact on the assessment and treatment of diabetic foot problems. This article describes a simple staging system to help in this important work.

Biomechanical Phenomena↗
PubMedDate not supplied

An overview of foot disease in patients with diabetes.

Effective management of diabetic foot disease requires a multidisciplinary approach and good communication between all healthcare professionals involved. This article provides an overview of the main factors that need to be considered when assessing patients with diabetic foot disease.

Aged↗