M Edery — Page 6 | Search PubMed

PubMed1980

Estradiol and progersterone receptors in F1 (C3H X RIII) mice mammary tumors: effect of castration.

The estradiol binding capacity has been determined in the cytosol of spontaneous mammary cancer in the high-mammary-tumor F1 (C3H X RIII) hybrid mice. This binding is modified neither during tumor growth nor after ovariectomy. Since these tumors do not regress after ovariectomy, they are classified as ovarian-independent for their growth, although their estradiol binding capacity is maintained, at its low initial level.

Animals↗

PubMed1976

[Analysis of biospecific complexes by electrophoresis: antibiotics specific to bacterial ribosomes].

Electrophoresis is a widespread method in biochemistry. Apparently it has never been used in the study of interactions found in enzyme-substrates or drug-receptor complexes. The aim of this Note is to describe some possibilities given by this simple technique especially in the case of interactions found between some antibiotics and the bacterial ribosome. Chloramphenicol, pristinamycin are located in 50 S subunit whereas dihydrostreptomycin is found in 30 S particle (fig). Such results have been previously obtained by other methods. The distribution of the gentamicin and kanamycin components is quite different. This suggests that the mechanism of action of these molecules may be different from that of streptomycin group antibiotics.

Anti-Bacterial Agents↗