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Biomedical subjects

M Eckstein

Publications and source records attributed to M Eckstein.

At least 55 records · Page 3Linked to original sources
PubMed1975

The search for new drugs in the group of xanthine derivatives. XXXVIII - 1,3-dimethyl-8-alkyl-6H,7H,10H-(1,2,4-)-triazepino(4,3-f)purine-2,4-(1H,3H)-diones and their derivatives.

Condensation of 1-(8'-chlorotheophyllinyl-7')-alkan-3-ones with hydrazine hydrate gave 8-alkyl derivatives of the new heterocyclic ring system: 1,3-dimethyl-6H,7H,10H-(1,2,4)-triazepino [4,3-f] purine-2,4-(1H,3H)-dione (I, II). 10-Acyl (III - VI) and 10-beta-cyanoethyl (VII, VIII) derivatives of compounds (I) and (II) were easy obtained in good yield. With p-nitrophenyl- and isonicotinoylhydrazines only the corresponding hydrazones of 1-(theophyllinyl-7')-alkan-3-ones (IX, X) were formed. In the attempt to obtain 10-aryl, hydroxyalkyl or acyl derivatives of the new tricyclic ring system by the reaction of 1-(8'-chlorotheophyllinyl-7')-butan-3-one with phenyl-, beta-hydroxyethyl- or acetylhydrazines only decomposition of the ketones to 8-chlorotheophylline and vinylketones was observed. The structures of the new compounds were confirmed by U.V. and N.M.R. spectroscopy and partly by mass spectrometry.

Chemical Phenomena↗
PubMedDate not supplied

Emergency medical services providers and weapons in the prehospital setting.

OBJECTIVES: To investigate emergency medical services (EMS) providers' experience with weapons encountered while working, and evaluate the training they have received regarding searching for and confiscating weapons in the field. METHODS: This was a descriptive, cross-sectional survey anonymously completed by a convenience sample of EMS providers in the metropolitan Boston and Los Angeles (LA) areas. RESULTS: Of 2,672 surveys distributed, 2,224 (83%) were returned. Forty-two percent of the respondents (39% of Boston and 46% of LA) reported searching patients for weapons, and 62% (51% of Boston and 76% of LA) reported finding weapons. The LA respondents were more likely than the Boston respondents to have found a firearm. Twenty-seven percent of the respondents reported they had found more than five weapons in their careers. One thousand seven hundred seventy-two (80%) providers replied that they would report discovered weapons, most frequently to law enforcement personnel. Providers with higher EMS education and ones who received weapons-related training were more likely to search for, find, and report weapons. Four hundred fifty-one (20%) respondents reported receiving formal weapons-related training, 291 (13%) considered their initial EMS training on weapons-related topics to be adequate, and 292 (13%) considered their continuing education in these areas adequate. CONCLUSIONS: These data suggest that weapons encountered in the field are a widespread problem for EMS providers. Although many EMS providers search for and find weapons on their patients, most of them feel they have been inadequately trained in this area. Prospective studies are needed to document the actual incidence of weapon encounters in the prehospital setting. Multidisciplinary discussions are needed to address the above issues.

Adult↗