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Biomedical subjects

M E Tumbleson

Publications and source records attributed to M E Tumbleson.

At least 37 records · Page 2Linked to original sources
PubMed1979

Serum electrolyte concentrations in Sinclair(S-1) miniature swine from 1 through 36 months of age.

Venous blood samples were collected monthly from 60 male and 60 female Sinclair(S-1) miniature swine from 1 through 36 months of age. The rate of serum urea nitrogen concentration decreased instantaneously for females and increased instantaneously for males as described in the equation y = aebt. Serum creatinine concentration decreased through 20 months of age and increased from 20 through 36 months of age. Serum calcium, inorganic phosphorus, potassium and sodium concentrations decreased instantaneously through 36 months of age. From 14 through 36 months of age, males had a greater mean serum urea nitrogen concentration than did females.

Age Factors↗
PubMed1979

Morphologic comparison of piglets from first and second litters in chronic ethanol-consuming Sinclair(S-1) miniature swine.

Piglets (L-1) from 13 litters farrowed by 1-year-old, first litter alcohol-consuming dams were evaluated for altered morphology, A second group of piglets (L-2) farrowed by 6 second litter alcohol-consuming dams also was evaluated. Mean litter size and birth weight for L-1 piglets were 4.85 and 602 +/- 152 g; mean litter size and birth weight for L-2 piglets were 2.00 and 478 +/- 168 g. Fetal mortality rates for L-1 and L-2 piglets were 15 and 25%, respectively. Anomaly rates observed in fetal deaths were 11 and 100% for L-1 and L-2 piglets, respectively. L-1 anomalies were macrocephaly, microphthalmia, necrosis of bowel, nonexternalization of penile tissue, unascended kidney and unilateral renal hypodevelopment. L-2 anomalies were anencephaly, microcephaly, nonfusion of cranial sutures, macrocephaly, microphthalmia, nonfusion of mandibles, cleft palate, imperforate cloaca, sydactyly and polydactyly.

Abnormalities, Drug-Induced↗
PubMed1977

Sources of normal variation of plasma lactate dehydrogenase in range cattle.

1. Plasma levels of lactate dehydrogenase (LD) were estimated in Hereford cattle of 1 month to 12 yr of age kept under range conditions. 2. Plasma levels of LD were estimated in a group of confined cows and their calves fed a constant diet and kept in individual pens in the same geographic area as the range Herefords. 3. Large seasonal changes in mean plasma LD were observed in the range cattle but not in the confined, constant diet group. The seasonal changes corresponded with the appearance of new growth on the range. 4. Changes in plasma LD were observed at weaning time in the range cattle but not in the confined group. 5. Sex had no effect upon plasma LD levels in the juvenile animals of either group. No comparison of adult animals could be made. 6. Mean plasma LD levels did not change with age but the seasonal effect decreased in magnitude as the animals matured. 7. An increase in plasma LD was observed around the first ovulation in the confined animals. 8. A decrease in plasma LD was observed during parturition in the confined group.

Animals↗
PubMed1977

Age and sex related changes of hematologic parameters in Sinclair(S-1) miniature swine.

Venous blood samples were collected monthly from 60 male and 60 female Sinclair(S-1) miniature swine from 1 through 36 months of age. Hematologic parameters evaluated included: erythrocyte count, packed cell volume, hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocyte count and differential leukocyte counts. Mean erythrocyte count increased from 3 through 9 months of age and declined thereafter. Mean packed cell volume and hemoglobin concentration decreased from 1 to 3 months of age, increased from 3 through 10 months of age and remained stable thereafter. From 7 through 36 months of age, females had greater mean packed cell volume and hemoglobin concentration than did males. Mean corpuscular volume and mean corpuscular hemoglobin increased linearly from 3 through 24 months of age and remained stable thereafter with females having greater mean corpuscular volumes and mean corpuscular hemoglobins than did males. Mean corpuscular hemoglobin concentration increased linearly from 1 through 30 months of age. Mean leukocyte count decreased from 1 through 9 months of age and remained stable thereafter. From 10 through 36 months of age, mean leukocyte count was greater for males than for females. From 6 through 24 months of age, mean per cent lymphocytes was greater for females than for males; whereas, mean per cent neutrophils was greater for males than for females.

Age Factors↗
PubMed1977

Alcohol-membrane interaction: calcium uptake in mitochondria.

A biphasic effect of ethanol was observed on Ca2+-uptake activity, Ca2+-uncoupled respiratory control ratio (CURCR), and State 3 oxygen uptake. At low concentrations (0.1-0.5%) ethanol enhanced these activities, probably as the result of an increase in membrane fluidity. At higher levels (0.7-4.0%) ethanol had an inhibitory influence on mitochondrial activities as the membrane macromolecules were probably disturbed due to the hydrophobic alcohol-membrane interaction.

Animals↗
PubMed1976

Serum protein concentrations and enzyme activities, as functions of age and sex, in Sinclair (S-1) miniature swine.

Venous blood samples were collected monthly from 60 male and 60 female Sinclair (S-1) miniature swine from 1 through 36 months of age. Serum total protein concentration increased linearly from 1 through 10 months of age and remained stable thereafter with no sex related difference. Serum albumin concentration decreased from 1 through 3 months, increased from 3 through 8 months and decreased from 14 through 36 months. From 2 through 36 months, serum alpha-globulin concentration decreased; whereas, serum beta-globulin concentration increased. Serum gamma-globulin concentration increased markedly from 1 through 3 months and continued to increase through 36 months of age. From 10 through 36 months, males had a greater mean serum gamma-globulin concentration than did females. Serum total globulin concentration increased most rapidly from 1 through 3 months, less rapidly from 3 through 18 months and remained stable thereafter. Serum albumin/globulin ratio decreased sharply from 1 through 3 months and continued to decrease from 6 through 36 months with females having a greater mean concentration than males. Serum glutamic-oxaloacetic transaminase activity decreased from 1 through 30 months with males having a greater mean activity than females from 7 through 36 months of age. Serum alkaline phosphatase activity decreased from 1 through 36 months of age with no sex related difference. Serum lactic dehydrogenase activity decreased from 1 through 30 months with females having a greater mean activity than males from 24 through 36 months of age.

Age Factors↗
PubMed1976

Serum cholesterol, triglyceride, glucose and total bilirubin concentrations, as functions of age and sex, in Sinclair(S-1) miniature swine.

Venous blood samples were collected monthly from 60 male and 60 female Sinclair (S-1) miniature swine from 1 through 36 months of age. Serum cholesterol concentration decreased from 5 through 36 months of age. Also, gilts had a greater mean serum cholesterol concentration than did boars. Mean serum triglyceride concentration was greater for females than for males. From 1 through 15 months of age, serum glucose concentration decreased with no sex related difference. From 1 1/2 to 3 years of age, gilts had greater mean serum glucose concentrations than did boars. Throughout the longitudinal study, mean serum total bilirubin concentrations were similar for females and males, with no age related variations.

Age Factors↗
PubMed1975

Effect of chronic ethanol ingestion on mitochondrial protein synthesis in Sinclair(S-1) miniature swine.

The effect of chronic ethanol ingestion on hepatic mitochondrial protein synthesis in miniature swine was investigated. After 3 wk on test, there was no decrease in the rate of amino acid incorporation between livers of control and ethanol consuming pigs. After 6 wk on test, there was a 33% decrease in rate of hepatic mitochondrial membrane protein synthesis in livers of experimental pigs, as compared with controls. When analyzed by SDS-gel electrophoresis, a decrease in labeling of the 40,000 mol wt peak, from both whole membrane protein and proteolipid protein profiles, was observed for livers from ethanol consuming pigs as compared with controls.

Animals↗