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Biomedical subjects

M E Tardy

Publications and source records attributed to M E Tardy.

At least 19 recordsLinked to original sources
PubMed1991

Variable histotoxicity of histoacryl when used in a subcutaneous site: an experimental study.

Histoacryl (butyl-2-cyanoacrylate) is one of the least histotoxic cyanoacrylate derivatives and is used as a tissue adhesive. Clinical applications primarily include skin closure (blepharoplasty incisions, etc.). In a recent study, we demonstrated that Histoacryl elicits minimal histotoxicity when used to glue bone grafts to rabbit-ear cartilage. Acute inflammation was limited to areas where Histoacryl escaped from between the bone graft and ear cartilage to contact well-vascularized soft tissue. In this study, Histoacryl was applied between bone graft and cartilage in one rabbit ear and adjacent to well-vascularized soft tissue with no graft in the opposite ear. Histologic analysis revealed minimal if any inflammation when small amounts of glue was used in the nonvascular region between bone graft and cartilage. However, subcutaneous implantation contacting well-vascularized soft tissue resulted in increased acute inflammation and prolonged foreign-body giant-cell response. Further studies are required to rule out any long-term problems associated with subcutaneous implantation of Histoacryl.

Administration, Cutaneous↗
PubMed1991

Aesthetic surgery of the face.

A large variety of safe and effective surgical procedures to achieve rejuvenation is currently available. If surgery is carefully and properly performed, with an emphasis on a conservative approach, lasting and gratifying results may be realized. Great care must be taken to select appropriate and highly motivated individuals for such procedures, from the standpoint of both psychologic maturity and ideal anatomic configurations. Furthermore, patients seeking aesthetic surgery are generally healthy and well, unlike patients who seek medical care for disease; surgeons must exercise extraordinary care to ensure that rejuventation surgery does not result in an unwell patient. Clearly, the ideal outcome is represented by a patient happy and gratified by his improvement and a surgeon proud of his resultant achievement.

Chin↗
PubMed1990

Histotoxicity of cyanoacrylate tissue adhesives. A comparative study.

Cyanoacrylate derivatives have been used as surgical adhesives for many years. Shorter-chain derivatives (methyl- and ethyl-cyanoacrylate) have proved to be histotoxic. Longer-chain derivatives (butyl- and isobutyl-cyanoacrylate) are much less histotoxic. Many surgeons continue to use ethyl-2-cyanoacrylate (Krazy Glue) despite the availability of a less toxic derivative, butyl-2-cyanoacrylate (Histoacryl). In this study, the histotoxicity and bone graft-cartilage binding ability of Krazy Glue and Histoacryl were compared. Bone grafts harvested from the anterior wall of the maxillary sinus were placed in a subcutaneous pocket and glued to auricular cartilage in the rabbit. Krazy Glue and Histoacryl were used in opposite ears, harvesting specimens at 1, 2, 4, 12, 24, and 48 weeks. The Krazy Glue-treated ears developed seromas with histologic evidence of acute inflammation, tissue necrosis, and chronic foreign body giant cell reaction. The Histoacryl-treated ears showed mild acute inflammation and mild foreign body giant cell reaction. The Krazy Glue was completely degraded within 12 months, while some Histoacryl was still present at 1 year. Histoacryl had minimal histotoxic effect and good bone graft-cartilage binding ability, whereas Krazy Glue demonstrated severe histotoxicity.

Animals↗
PubMed1987

Misadventures in nasal tip surgery. Analysis and repair.

Nasal tip surgery is a compromise, in which the surgeon gives away something to achieve something--a narrower, more defined, and stable tip component of the nose. Years of experience are required to thoroughly understand and master tip surgery techniques. While gaining this arduous but invaluable insight, emphasis should always be placed on conservation of tip anatomic structures and avoidance of radical excision and sacrifice of tip tissue. Compulsive long-term follow-up and evaluation of patients, both by frequent examination and review of standardized, uniform photographs, best facilitates the development of expertise in nasal tip surgical refinement.

Humans↗
PubMed1985

The versatile cartilage autograft in reconstruction of the nose and face.

This paper deals with the long-term follow-up of cartilage autografts taken from various parts of the body to reconstruct areas of the nose, ear, trachea, eyelid, and other areas of the body which require augmentation, effacement, and long-term support. Our thesis will be that the cartilage autograft is the implant of choice in many of these areas, and that fate of autogenous cartilage is well known and should be given strong priority in facial grafting.

Cartilage↗
PubMed1985

The precise midline forehead flap in reconstruction of the nose.

The midline forehead flap has been a preferred choice for nasal repair in our practice for over 20 years, with no significant complication ever having developed (Figs. 9 to 11). The abundance and length of tissue it provides is remarkable, given the inconspicuous defect remaining in the forehead area. Its use is economical of tissue, time, and expense to the patient. Most importantly, the midline flap provides superior aesthetic and reconstructive repair in a relatively short period of time without resorting to more complicated, and therefore more risky, flap designs.

Adult↗
PubMed1981

Otoplasty--a contemporary survey.

This report examines the various common congenital auricular deformities categorized under the broad heading of the "outstanding ear" and reviews briefly the major contributions to otoplasty surgery.

Child↗