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Biomedical subjects

M E Stuart-Taylor

Publications and source records attributed to M E Stuart-Taylor.

7 recordsLinked to original sources
PubMed2003

Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen trometamol with ketoprofen or placebo after major orthopaedic surgery.

AIMS: Multimodal analgesia is thought to produce balanced and effective postoperative pain control. A combined therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) and opiates could result in synergistic analgesia by acting through different mechanisms. Currently there are very few parenterally administered NSAIDs suitable for the immediate postoperative period. Therefore, this study was undertaken to assess the analgesic efficacy, relative potency, and safety of parenteral dexketoprofen trometamol following major orthopaedic surgery. METHODS: One hundred and seventy-two patients elected for prosthetic surgery, were randomized to receive two intramuscular injections (12 hourly) of either dexketoprofen 50 mg, ketoprofen 100 mg or placebo in a double-blind fashion. Postoperatively, the patient's pain was stabilized, then they were connected to a patient- controlled analgesia system (PCA) of morphine for 24 h (1 mg with 5 min lockout). RESULTS: The mean cumulative amount of morphine (CAM) used was of 39 mg in the dexketoprofen group and 45 mg in the ketoprofen group vs 64 mg in the placebo group. (Reduction in morphine use was approximately one-third between the active compounds compared with placebo (adjusted mean difference of -25 mg between dexketoprofen and placebo and -23 mg between ketoprofen and placebo. These differences were statistically significant: P </= 0.0003; 95% CI -35, -14. Pain-intensity scores were consistently lower with the active compounds, the lowest corresponded to the dexketoprofen-treated patients. Regarding sedation, there were statistically significant differences between the two active compounds and placebo only at the 2nd and 13th hours. Wound bleeding was specifically measured with no statistically significant differences found between all the groups. CONCLUSIONS: Intramuscular administration of dexketoprofen trometamol 50 mg has good analgesic efficacy both in terms of opioid-sparing effect and control of pain after major orthopaedic surgery.

Adolescent↗
PubMed1997

Calculation of drug dosage and body surface area of children.

The British National Formulary and many reference textbooks recommend that drug dosages for children be calculated according to body surface area (BSA). Although many rules for drug dosage have been developed, based on age, weight and surface area, none has been accurate and simple enough for routine use. These rules are described, and one for clinical use: up to 30 kg, a child's drug dose may be (wt x 2)% of an adult dose; over 30 kg, (wt + 30)% of an adult dose. If this percentage of an "adult" dose of a drug is used, not only is the BSA curve followed more closely than with the conventional mg kg-1 regimen, but fewer major errors of prescription may be expected.

Adolescent↗
PubMed1993

Why do anaesthetists need codes?

With the increasing availability of information technology in hospitals and the introduction of medical audit and resource management, there is a proliferation of anaesthetic data collection systems. The amount of data recorded varies from a complete anaesthetic record to a small subset of it. Most systems hold data in coded form for reasons of accuracy and compactness. Unfortunately, all the coding systems are different, making comparisons between different centres difficult. We propose that there is a need to develop a standard national system for coding anaesthetic terms.

Anesthesiology↗
PubMed1992

Extradural diamorphine for postoperative analgesia: audit of a nurse-administered service to 800 patients in a district general hospital.

We report the use of extradural diamorphine for postoperative analgesia as a nurse-based service on selected surgical wards in a district general hospital. Eight hundred patients received lumbar or thoracic extradural diamorphine analgesia for postoperative or traumatic pain. Diamorphine was administered in bolus form by suitably trained nursing staff. Satisfactory analgesia, recorded on a verbal rating scale at the conclusion of the service, was achieved in 94.6% of patients. The technique was considered by medical and nursing staff to be a safe and acceptable method of analgesia. Respiratory depression, defined as a ventilatory frequency of less than 10 b.p.m., occurred in seven patients (incidence of 0.9%). All occurred in the theatre recovery area or in the intensive care unit. Retrospectively, each was predictable and all responded to naloxone 0.4 mg.

Adolescent↗
PubMed1989

A plea for noradrenaline.

Hypotension induced by nifedipine and chlorpromazine is discussed, together with the role of noradrenaline in the correction of this problem, which was resistant to other forms of therapy.

Chlorpromazine↗
PubMed1987

Alfentanil infusions. Comparison of bolus administration of fentanyl with three alfentanil infusion regimens.

Three different dosage regimens of alfentanil were compared with boluses of fentanyl in 80 patients who underwent a variety of surgical procedures. Alfentanil given by infusion at a rate of 7.5 micrograms/kg/minute for 10 minutes followed by 0.75 micrograms/kg/minute, was shown to provide a stable anesthetic which minimises the use of a volatile agent for surgery that lasts more than 45 minutes.

Adolescent↗