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Biomedical subjects

M E Ross

Publications and source records attributed to M E Ross.

85 records · Page 5Linked to original sources
PubMed1976

Virus-induced diabetes mellitus. IV. Genetic and environmental factors influencing the development of diabetes after infection with the M variant of encephalomyocarditis virus.

The M variant of encephalomyocarditis virus (EMC) infects pancreatic beta cells and causes the development of a diabetic syndrome in susceptible strains of mice. By examining four F1 crosses of susceptible and resistant strains of mice, we found that the development of diabetes after infection was inherited as a recessive trait. Analysis of the data from the F2 generation indicated that more than one gene was involved in the development of EMC-diabetes. The severity and frequency of abnormal glucose levels in EMC-infected animals was markedly influenced by environmental factors.

Animals↗
PubMed1976

Quantitative evaluation of serum pancreatic isoamylases in cystic fibrosis.

The amylase in sera of 20 patients with cystic fibrosis of the pancreas (CFP), 17 of whom had pancreatic insufficiency (PI), and of 34 normal control subjects was separated into its pancreatic and salivary components and quantitated. Electrophoretic separation was achieved on polyacrylamide disc gels with subsequent sectioning of the gel columns. The amylase content in international units per liter (IU/L.) was obtained for each section by the insoluble blue starch substrate method. The mean total serum amylase of the CFP patients with PI was significantly lower than the control group. A highly significant decrease was found when the pancreatic isoamylase was considered alone. The salivary isoamylase level remained essentially the same. Three patients with CFP but without PI demonstrated higher than normal pancreatic amylase values in the serum. These patients may be in an early stage of a progressive involvement of the pancreas in which there is an increased release of amylase. This method of electrophoretic separation and quantitation of the serum amylase is sensitive and efficient and allows the simultaneous processing of multiple specimens. The results obtained agree with previously published ratios of serum isoamylases. Our method should be valuable in the study of other diseases of the exocrine pancreas and salivary glands.

Adolescent↗
PubMed1976

Persistence of mumps viral antigens in mouse brain.

Newborn mice were infected intracerebrally with a fresh isolate of mumps virus. Although infectious virus could not be recovered after the acute infection, direct immunofluorescence demonstrated the persistence of mumps antigens for up to 100 days after the initial infection.

Animals↗
PubMed1968

The effect of N-bromosuccinimide on the sub-unit structure of acidin and its complexes with biotin.

1. Each molecule of biotin bound to avidin protected four tryptophan residues from oxidation by N-bromosuccinimide, regardless of the occupancy of neighbouring binding sites in the four-sub-unit avidin molecule. 2. The oxidation products from avidin molecules in which some of the sites were occupied were separated on columns of Sephadex G-100. In the absence of biotin, oxidized avidin broke down into sub-units, which partly aggregated. When some of the sites were occupied by biotin, the only detectable products were completely oxidized avidin (sub-units and large aggregates) and unoxidized avidin-biotin complex (tetramer). Since the biotin-containing sub-units were randomly distributed before oxidation took place, they must have dissociated from the molecules containing oxidized sub-units and then reassociated to form the tetrameric avidin-biotin complex. 3. This reassociation still occurred in 3.5m-guanidinium chloride, which prevents the reassociation of unoccupied sub-units. During their brief existence in this medium, the sub-units of avidin-biotin complex were protected from oxidation by N-bromo-succinimide to the same extent as was the tetrameric complex. 4. It is concluded that sub-units of avidin-biotin complex do not readily lose their biotin, even in 3.5m-guanidinium chloride, and that monomeric biotin-binding species are probably present in solutions of avidin sub-units at guanidinium chloride concentrations between 3.0m and 3.5m.

Binding Sites↗
PubMedDate not supplied

Settling an ongoing debate with one entry level.

It is time that nursing settle this controversy regarding entry level to practice. In order to obtain full colleagueship with other professionals, improve the quality of care and the image of nursing, and receive a sound educational base, nursing should require the Bachelor of Science in Nursing degree as the minimal entry level for practice.

Education, Nursing, Baccalaureate↗
PubMedDate not supplied

Hardiness and compliance in elderly patients with diabetes.

The purpose of this study was to determine if the presence of the hardiness personality characteristic influences compliance. The sample (N = 50) for this study was obtained from a hospital in a large metropolitan area of the United States. The majority of subjects were white, male, married, and diagnosed with type II diabetes. Instruments used to collect data were the Health-Related Hardiness Scale and the Self-Management Compliance Questionnaire. Results indicated that a significant correlation existed between the hardiness and compliance variables. Thirty-six percent of the variance in the compliance score was explained by the total health-related hardiness scores. Findings suggest that the degree of hardiness in individuals with diabetes may predict compliance to a prescribed diabetic regimen.

Adaptation, Psychological↗