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Biomedical subjects

M E O'Brien

Publications and source records attributed to M E O'Brien.

At least 109 records · Page 6Linked to original sources
PubMed1981

Platelet abnormalities as related to diabetic retinopathy (with special reference to platelet shape change).

Abnormalities of platelet function may be related to the pathogenesis of diabetic retinopathy. A method for the in vitro assessment of platelet shape change (PSC), as induced by ADP in calcium-deprived platelet-rich plasma, is presented. The outcome of this test is dependent on the concentrations of ADP and of the chelating agent used. Studies in electron microscopy shoed that the parameter measured is not related to the disappearance of spiny-spherical forms. The values measured for PSC were significantly increased in a group of diabetic subjects, when compared to normal controls. In particular, patients with proliferative retinopathy showed more profound alterations of the PSC. No relations were found between the PSC values and ADP induced platelet aggregation, the plasma levels of von Willebrand factor and of factor VIII-related antigen.

Adenosine Diphosphate↗
PubMedDate not supplied

Hemodialysis regimen compliance and social environment: a panel analysis.

This correlational panel analysis, which investigated compliance behavior of chronic hemodialysis patients, was based on the assumption that attitudes and behaviors are influenced by those of significant others with whom the patient interacts on a continuing basis. Data for the study were collected initially and after a three-year interval, when a panel of 63 patients was identified. Study variables were operationalized by scales relating to social environment and compliance with the hemodialysis regimen. Analysis revealed the existence of statistically significant associations between patients' perceptions of the expectations of significant others, in terms of both primary group members--i.e., family and friends--and secondary group members--i.e., hemodialysis center personnel--and compliance. Multiple regression procedures were used to evaluate these relationships while holding constant the variable of education.

Adult↗