The thiol group of the L-arabinose-binding protein. Chromophoric labeling and chemical identification of the sugar-binding site.
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Arabinose↗
Biomedical subjects
M E Newcomer
Publications and source records attributed to M E Newcomer.
7alpha, 15beta-Dichloro-5alpha-cholest-8 (14)-en-3beta-ol, a novel inhibitor of sterol biosynthesis in animal cells.
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Acetates↗
Crystallographic and chemical studies of the L-arabinose-binding protein from E. coli.
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Arabinose↗
The structure of beta-lactoglobulin and its similarity to plasma retinol-binding protein.
Since its first isolation, bovine beta-lactoglobulin (BLG) has been an enigma: although it is abundant in the whey fraction of milk, its function is still not clear. The results of the many physicochemical studies on the protein need a structural interpretation. We report here the structure of the orthorhombic crystal form of cow BLG at pH 7.6, at a resolution of 2.8 A. It has an unusual protein fold, composed of two slabs of antiparallel beta-sheet, which shows a remarkable similarity to plasma retinol-binding protein. A possible binding site for retinol in BLG has been identified by model-building. This suggests a role for BLG in vitamin A transport and we have discovered specific receptors for the BLG-retinol complex in the intestine of neonate calves.
Animals↗