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Biomedical subjects

M E Miller

Publications and source records attributed to M E Miller.

317 records · Page 18Linked to original sources
PubMedDate not supplied

Visual and quantitative computerized assessment of disease severity on peripheral angiograms.

PURPOSE: This study was designed to determine and compare the intra- and interobserver variability of visual and computerized assessment of peripheral arterial disease (PAD) severity from lower extremity angiograms, and to correlate quantitative angiographic measures with clinical predictors of PAD. PATIENTS AND METHODS: Peripheral angiograms of 13 segments from the ilio-femoral-popliteal system were evaluated on two separate occasions by nine radiologists and with a quantitative computerized method. In a separate study, images from 18 patients undergoing diagnostic lower extremity angiography were analyzed with use of quantitative angiography and the results were compared with clinical and lipid risk factors. RESULTS: The data demonstrate that computerized assessment of peripheral angiograms is associated with lower intra- and interobserver variability than visual assessment of the same films. Despite this, there was excellent intraobserver and good interobserver agreement on the presence or absence of a severe lesion with visual assessment. Quantitative computerized measures of disease severity correlate with several known predictors of large vessel PAD. CONCLUSION: Computerized assessment of peripheral angiograms may be a useful tool in the clinical and investigational evaluation of PAD.

Aged↗
PubMedDate not supplied

Impact of the nutritional regimen on protein catabolism and nitrogen balance in patients with acute renal failure.

BACKGROUND: Patients with acute renal failure are in substantial negative nitrogen balance as a result of their extremely high protein catabolic rates. We prospectively evaluated a series of patients with acute renal failure managed with continuous venovenous hemofiltration to determine which nutritional and nonnutritional variables might influence protein catabolism and nitrogen balance. METHODS: Forty consecutive patients (aged 52 +/- 20 years; mean +/- SD) were monitored for 357 treatment days (average treatment duration 8.9 +/- 8.6 days). All data (including nutritional regimen, laboratory values, APACHE II score, administered blood products, hemofiltration parameters, and medications) were collected daily. RESULTS: For all patients, the mean normalized protein catabolic rate was 1.4 +/- 0.5 g/kg per day. The rate did not differ between those who received nutrition support and those who did not. The net nitrogen deficit was less in those patients receiving nutrition support (-6.0 +/- 5.2 vs -14.0 +/- 5.6 g N/d; p = .02). Using regression techniques (adjusted for the within-person correlation and the previous day's normalized protein catabolic rate), the level of protein and energy provision and the interaction between protein and energy provision were predictive of the normalized protein catabolic rate. Predicted values, using this equation, suggest that at low protein administration rates (< 1 g/kg per day), increasing energy provision may reduce the protein catabolism. However, at this level of protein provision, patients remain in negative nitrogen balance. At protein administration rates necessary to achieve nitrogen balance (approximately 1.5 to 1.8 g/kg per day), protein catabolism may increase. Providing relatively low levels of energy may diminish the magnitude of this increase. CONCLUSION: These results suggest that the optimal nutritional regimen for patients with acute renal failure may require a high-protein (approximately 1.5 to 1.8 g/kg per day) and a relatively low-energy (approximately 25 to 35 kcal/kg per day) content.

Acute Kidney Injury↗
PubMedDate not supplied

Validation of probabilistic predictions.

Current advances in high-speed computing and increased availability of statistical software have led to widespread use of statistical methods for the development of computerized protocols predictive of binary health outcomes. If these predictive algorithms are to be used in settings other than those for which they were developed, e.g., applied in a different geographic setting or extrapolated for use in a slightly different population, then they should be carefully validated to ensure appropriate application. Miller et al. (Stat Med. 1991) provided a comprehensive methodology for external validation of logistic prediction models, and applied these methods in a temporal validation setting. In this article, the authors emphasize how these methods can be applied to general forms of probabilistic predictions and provide several SAS macros for computation of the desired statistics.

Adolescent↗
PubMedDate not supplied

Use of modified Boston brace for back injuries in athletes.

The Boston Brace System was developed to attain functional realignment of the scoliotic spine. This system uses prefabricated thermoplastic pelvic modules which can be rapidly fitted to an individual patient. These modules are available in 20 sizes and designed with a forward flexion of 30 degrees on the anterior margin and 15 degrees on the posterior surface. The resultant antilordotic straightening of the lumbar spine is important in correcting the scoliotic spine and has been found to be therapeutically effective in managing a number of other conditions of the spine, including back injuries in the young athlete. A review of the results of treatment of 31 young athletes for back injuries over the past 3 years with the brace, with an average followup of 15 months, reveals good or excellent results in 28 of the 31, or 90%. Best results were attained in spondylolysis. Therapy for discogenic back pain with the brace was effective in only 50%. Modifications of initial brace design included changing from a posterior opening to an anterior opening module and from polypropylene to polyethylene brace construction. Most patients have continued full athletic participation while in the brace.

Athletic Injuries↗
PubMedDate not supplied

No effect of smoking on sulfamethazine acetylation.

Seven healthy subjects who smoked at least one pack of cigarettes/d were acetylator-phenotyped with sulfamethazine (SMZ) while they were actively smoking, and again at least one month after they had completely stopped. There were no significant differences of the acetylation profiles in the smoking vs. nonsmoking state, as measured by %ASMZ in serum six hours post-SMZ dosing or by %ASMZ in urine five to six hours post-SMZ dosing. We conclude that smoking does not influence SMZ acetylation and probably does not affect drug acetylation in general.

Acetylation↗
PubMedDate not supplied

Occupational asthma caused by FD&C blue dye no. 2.

We report the case of a 55-year-old male who experienced cough, dyspnea, wheezing, and nasal congestion immediately upon exposure to FD&C Blue Dye No. 2 (Indigotine) at work. The patient had worked for 10 years mixing and grinding powdered synthetic red, yellow, and blue dyes for use in foods; symptoms had occurred for 2 years and only with exposure to Indigotine (C16H8N2Na2O8S2), a free flowing blue powder. Prick testing to Indigotine (20 mg/mL) was negative. ELISA failed to detect specific IgE, IgA, IgM, or IgG to Indigotine-HSA conjugates. Bronchial challenge was done according to the method of Pepys et al. beginning with 4 x 10(-4) lactose dilution of Indigotine powder. After 5 minutes of exposure to 4 gm Indigotine/100 gm lactose, the patient developed dyspnea and audible wheezing. At 20 minutes postexposure, there was a 20% decline in FEV1 from prechallenge baseline; no late phase response was observed. A second bronchial challenge with sodium sulfate, the major nondye product additive was negative. To our knowledge, this is the first documented case of occupational asthma due to FD&C Blue Dye No. 2. The pathogenesis is uncertain but does not appear to be IgE mediated.

Asthma↗
PubMedDate not supplied

The cancer amputee and sexuality.

To the person experiencing amputation, the loss of a limb has a serious psychosexual impact. Whatever the age, the surgical procedure itself, pain, deformity, inability to perform simple customary acts, economic threat, and many other problems impose on the person facing the loss of their limb. Commonly, concentration is focused on functional abilities during and after prosthetic rehabilitation, and care taken to preserve the person's sexuality is often omitted. Major limb amputation can cause a decrease in self-esteem and body image due to perceived mutation, and this in turn can create emotional hurdles for both the patient and partner. Several potential problems such as the mechanics of body positioning during sex play, balance and movement, and phantom pain sensations can alter sexual function. Added difficulties include chemotherapy-induced neuropathies and enforced isolation because of limited mobility. Although these various disabling maladies may require alterations in a sexual relationship, sex drive and desire usually remain intact. Specific assessment techniques and interventions must be made available to enable the nurse to discuss sexual concerns at all stages of cancer and its treatment. As well, we must not fail to see alternatives to stereotypical behavior and acknowledge each patient's unique sexual identify.

Adaptation, Psychological↗