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Biomedical subjects

M E Clouse

Publications and source records attributed to M E Clouse.

At least 73 records · Page 4Linked to original sources
PubMed1985

Lymphangiography, ultrasonography, and computed tomography in Hodgkin's disease and non-Hodgkin's lymphoma.

Findings from histologic analysis, lymphangiography, ultrasonography, and computed tomography were reviewed for 54 cases of Hodgkin's disease and 18 cases of non-Hodgkin's lymphoma. All patients were classified as clinical stage 1 or 2 disease at the time of the imaging studies. The ultrasound and computed tomography studies identified only 30 to 40% of the truly positive patients. This low sensitivity contrasts with lymphangiography, which identified 95% of the truly positive Hodgkin's disease patients and 70% of the patients with abdominal spread of non-Hodgkin's lymphoma. Many errors in interpretation were attributable to location and distribution of disease in these patients and the differing patterns of spread in Hodgkin's disease and non-Hodgkin's lymphoma. The evidence indicates that when findings are positive on computed tomography or ultrasound, no other study is necessary. In stage 1 or 2 lymphoma, non-Hodgkin's patients with negative noninvasive findings and all Hodgkin's patients, regardless of their noninvasive findings, should undergo lymphangiography.

Abdomen↗
PubMed1985

Delayed images of glucoheptonate distribution after renal transplant.

Thirteen consecutive patients who had undergone renal transplantation were scanned 24 hours after glucoheptonate injection to document the incidence of gastrointestinal activity mimicking urinary extravasation. In six of the 13 patients, the activity was clearly within the small bowel or the colon but, in seven patients, the activity was noted surrounding the renal allograft. Using scintigraphy alone, it could not be determined whether this appearance represented cecal activity or urinary extravasation.

Adult↗
PubMed1985

Subintimal dissection of peritoneovenous shunt tubing. Demonstration with radionuclide study.

A case report is presented in which malfunction of a peritoneovenous shunt was caused by subintimal dissection of the venous end of the shunt tubing. The radionuclide shunt patency study demonstrated a collection of radioactivity at the venous end of the tubing, representing the abnormal intramural collection of peritoneal fluid. Scintigraphic demonstration of this complication of a peritoneovenous shunt has not been reported previously.

Ascites↗
PubMed1985

Simple liver perfusion model for NMR spectroscopic analysis.

We developed a model to study the perfused mouse liver by nuclear magnetic resonance spectroscopy and to sample perfusate as it exited the liver within a vertical-bore spectrometer. The technique consists of rapidly cannulating the portal vein for perfusate inflow, and then suspending the organ in a bath of perfusate. An outlet at the bottom of the NMR tube provides easy access to concentrated samples of the perfusate exiting the liver. A suction outlet located just above the liver removes excess perfusate from the NMR tube. The perfusing medium is oxygenated Krebs-Henseleit buffer perfused at 8 ml/min. We demonstrated excellent P-31 spectra on the mouse liver. The liver energy charge is maintained as reflected in a constant ATP/Pi. We also showed the effects of ischemia and anoxia upon the liver, and correlated these P-31 spectra with biochemical measurements of liver enzyme release. This model was adapted for use in an Oxford wide-bore (89-mm) 8.4 T magnet with a 2-cm NMR tube to study P-31 spectra, liver enzyme and electrolyte release in ischemic and anoxic livers, but it can be used for spectroscopy of any nuclei in any vertical-bore spectrometer.

Animals↗
PubMed1985

Sphincter of Oddi stenosis: diagnosis using hepatobiliary scintigraphy and endoscopic manometry.

To determine the role of radionuclide imaging in diagnosing sphincter of Oddi stenosis, 21 patients with symptoms suggesting this disorder underwent endoscopic retrograde cholangiopancreatography, cholescintigraphy, and, when possible, endoscopic manometry. Those patients with abnormal hepatobiliary scintigraphy results--based on our criteria of delayed biliary intestinal transit, abnormal duct size, and abnormal time-activity dynamics and obstruction--had a mean basal sphincter pressure of 38.5 mm Hg. Sphincter pressures could not be measured in six patients with sphincters too tight to cannulate. Ten patients who underwent hepatobiliary scanning both before and after sphincter surgery had normal scan results on the repeat study. Hepatobiliary imaging appears useful for diagnosis of sphincter of Oddi stenosis in selected patients in whom manometry cannot be performed and for objective assessment of response to therapy.

Adult↗
PubMed1985

Focal splenic disease demonstrated by ultrasound and computed tomography.

Twenty-five patients with focal splenic disease were analyzed retrospectively to determine the relative strengths and weaknesses of ultrasound and computed tomography (CT) in the detection and analysis of focal splenic lesions. Lesions were detected in all 25 patients by ultrasonography and in 22 of 25 patients by CT. Ultrasonography appears to be more sensitive in the detection of focal lymphoma within the spleen and may be slightly more sensitive in the detection of microabscesses. CT may offer more specific information regarding the nature of certain lesions, including the detection of cyst wall calcification, gas within an abscess, and the specific site of origin of tumor invading the spleen. Ultrasonography may at times be more specific in the diagnosis of cystic lesions. We recommend ultrasonography as the first method for splenic imaging with CT used when necessary for further characterization of focal lesions.

Abscess↗
PubMed1984

Peripancreatic lymph node enlargement in Hodgkin's disease, non-Hodgkin's lymphoma, and pancreatic carcinoma.

The distribution of enlarged lymph nodes in the upper abdomen and retroperitoneum were classified according to their relationship to the pancreas in 47 patients with non-Hodgkin's lymphoma; in nine patients with Hodgkin's disease; and in 40 patients with pancreatic carcinoma. Four patterns of lymph node enlargement were evident: (1) preaortic retropancreatic lymphadenopathy; (2) pancreaticosplenic lymphadenopathy; (3) isolated celiac and/or portal lymphadenopathy; and (4) diffuse extensive lymphadenopathy. Features differentiating lymphoma from primary pancreatic neoplasm are discussed.

Adult↗
PubMed1984

Liposarcoma involving the scapula.

An unusual case of a soft tissue liposarcoma arising in the upper limb was studied by computed tomography. Computed tomography suggested the diagnosis of myxoid liposarcoma using the criteria of textural inhomogeneity and bony erosion and scalloping of the scapula.

Aged↗
PubMed1984

Predictive value of perfusion defect size using N-isopropyl-(I-123)-p-iodoamphetamine emission tomography in acute stroke.

Sixteen patients with acute cerebral infarction who were studied with N-isopropyl-I-123-p-iodoamphetamine (IMP) brain scans were followed to determine if the extent of perfusion abnormality was predictive of the clinical course. Lesion size and diminished density on the scans appeared to correlate well with presenting symptoms, but were not predictive of outcome. When evaluated by IMP scanning in conjunction with computerized tomography, however, a group of patients could be identified in whom therapy may improve prognosis.

Acute Disease↗
PubMed1983

Transcatheter embolotherapy for congenital renal arteriovenous malformations. Long-term follow-up.

Transcatheter embolization was performed five times in 3 patients with congenital renal arteriovenous malformations (AVM). The patients were followed for one to seven and a half years. Two patients whose AVM were completely occluded with Gelfoam have been asymptomatic with no evidence of hematuria. A third patient, embolized with Gelfoam and Ivalon without complete occlusion of the AVM, bled ten months after the first procedure, was re-embolized, and later had the AVM removed surgically. Superselective transcatheter embolization should be the initial treatment modality for congenital AVM with the aim to control bleeding and occlude those malformations supplied by the terminal portion of interlobar arteries. Large malformations supplied by multiple feeders may require operative ligation and removal of the AVM when vessels cannot be occluded satisfactorily because of massive shunting.

Adult↗
PubMed1983

Multicystic renal cell carcinoma.

This is a case report of a patient with cystic renal cell carcinoma that had all of the ultrasound and computed tomographic features of benign multicystic renal disease. Although this benign entity is a possibility in some patients, thick-wall cystic lesions of the kidney must be considered malignant until proven otherwise and surgery cannot be avoided.

Adenocarcinoma↗
PubMed1983

Assessment of tumor response by computed tomography liver volumetry.

The volumes of hepatic tumors were calculated before and after therapy in 12 patients. The results were compared with clinical response, radionuclide scans, and initial qualitative computed tomography (CT) reports. A strong correlation was found between tumor volume determination and clinical response (9 of 12 patients). In only 4 of 10 patients did radionuclide scans agree with clinical response; the initial qualitative CT report disagreed with clinical response and quantitative CT response in four patients. Quantitative CT measurement was more accurate than qualitative CT evaluation and thus should be refined to offer a clinically useful addition to CT evaluation.

Follow-Up Studies↗