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Biomedical subjects

M E Brennan

Publications and source records attributed to M E Brennan.

14 recordsLinked to original sources
PubMed1997

The globin fragment LVV-hemorphin-7 is an endogenous ligand for the AT4 receptor in the brain.

Angiotensin IV (Val-Tyr-Ile-His-Pro-Phe) has been reported to interact with specific high-affinity receptors to increase memory retrieval, enhance dopamine-induced stereotypy behavior, and induce c-fos expression in several brain nuclei. We have isolated a decapeptide (Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe) from sheep brain that binds with high affinity to the angiotensin IV receptor. The peptide was isolated using 125I-angiotensin IV binding to bovine adrenal membranes to assay receptor binding activity. This peptide is identical to the amino acid sequence 30-39 of sheep betaA- and betaB-globins and has previously been named LVV-hemorphin-7. Pharmacological studies demonstrated that LVV-hemorphin-7 and angiotensin IV were equipotent in competing for 125I-angiotensin IV binding to sheep cerebellar membranes and displayed full cross-displacement. Using in vitro receptor autoradiography, 125I-LVV-hemorphin-7 binding to sheep brain sections was identical to 125I-angiotensin IV binding in its pattern of distribution and binding specificity. This study reveals the presence of a globin fragment in the sheep brain that exhibits a high affinity for, and displays an identical receptor distribution with, the angiotensin IV receptor. This globin fragment, LVV-hemorphin-7, may therefore represent an endogenous ligand for the angiotensin IV receptor in the CNS.

Adrenal Glands↗
PubMed1983

Aspiration of enlarged parathyroid glands for parathyroid hormone assay.

Enlarged parathyroid glands were percutaneously aspirated under computed tomographic (CT) control in 7 patients, and levels of parathyroid hormone (PTH) and human thyroglobulin (HTg) were measured. All 7 patients had high levels of PTH in at least 1 specimen. It is concluded that the measurement of high concentrations of PTH in the aspirate from a cervical or mediastinal mass, with CT documentation of needle position, provides absolute localization of parathyroid masses.

Adenoma↗
PubMed1980

The relationship between mortality and two indicators of morbidity.

The Resource Allocation Working Party concluded that standardised mortality ratios are the best available indicators of geographical variations in morbidity. In this paper we give the results of a statistical analysis of the relationship between mortality and two indicators of morbidity, obtained from the 1971 census, for three age groups. The level of aggregation in the data is comparable with that at district or area level. Strong linear relationships are obtained, suggesting that it is reasonable to use mortality data in the RAWP formulae in applications at area of district level. However, this method of resource allocation should not be used in isolation from planning. A possible solution which reduces conflict between the two approaches is to incorporate mortality data in the planning indicators used to establish relative need and, in addition, to take due account of established patterns of service and local circumstances.

Adolescent↗
PubMed1978

Association of childhood mortality with housing status and unemployment.

The association between mortality at the ages of 0-4 and 5-14 years in the county boroughs of England and Wales for 1971, using Kendall's correlation technique, and a variety of socioeconomic indicators, was computed. Kendall's partial correlation technique was used to determine whether any association remained when the effect of social class and unemployment was kept constant. At ages 0-4 years there was a significant and positive association between mortality and low socioeconomic position, high density housing, inadequate housing amenities, and the unemployment rate (P less than 0.001). A significant association with the housing variables remained when the effect of socioeconomic status and unemployment was kept constant. Between the ages 5-14 years there was a statistically significant association (P less than 0.001) between mortality and housing density which was eliminated when the effect of social class was held constant. There was no association between unemployment and mortality in this age group.

Adolescent↗
PubMed1974

Extension of family planning service in general practice.

All general practitioners on the list of a single executive council were contacted and 91% were interviewed. They were asked about the type of family planning service currently provided and their willingness to extend the service. Only 3% said that they were not providing any service at the time of interview, but only 4% stated that they provided a complete range of techniques to all patients; almost two thirds of practitioners only provided advice and the "pill". Lack of training in family planning techniques emerged as the most important factor in determining the type of service provided. At the time of interview 64% of doctors stated that they would like further training, and 35% of all doctors asked for a full course of clinical training. Many general practitioners (81%) were willing to extend their family planning services but 65% wanted financial reimbursement and 50% needed additional administrative support as prerequisites.

Comprehensive Health Care↗