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Biomedical subjects

M E Amasio

Publications and source records attributed to M E Amasio.

17 recordsLinked to original sources

[Septorhinoplasty in childhood].

Septorhinoplasty plays an important role in childhood, particularly from the functional point of view. In fact, normal nasal respiration makes it possible to develop physical harmony throughout the entire body, particularly within the facial area. Nasal respiration serves as a defense mechanism, filtering air, thus relieving the lower respiratory tract of some work during the episodes of upper aero-digestive tract infection and inflammation so typical of childhood and early adolescence. The surgical indications should consider the central points in nasal surgery in childhood: there must be marked functional compromise; the aesthetic defect, if present, must be highly evident; the surgical treatment must be as limited and focused as possible as to prevent interfering with subsequent development of the nose, paranasal sinuses and facial structures. In those cases where the above conditions are not found, it is advisable to postpone surgery until the child has reached 16 years of age, when the development of the nasal and facial skeleton has been completed.

Adolescent

[Fine needle biopsy in the preoperative diagnosis of parotid tumors].

Fine-needle aspiration biopsy is of particular interest in the parotid sites because, here, pathology with different treatments and prognosis manifest themself in the same way. The preoperative diagnosis of neoplasm is often problematic. As is known, this is correlated to several factors including histology, clinical and instrumental semiology. The instrumental image techniques (sialography, thermography, scintigraphy, ultrasound diagnosis, tac sialo-tac) give information as to size and location of the mass in question. Only rarely does it give any indication of whether the mass is malignant or benign. The authors systematically studied 386 parotid tumors. The method utilises a traditional technique (needle n. 12/2 gauge 1/4) and microscope examination with immediate dyeing to verify the correctness of the sample. 352 cases underwent surgery with subsequent histological verification. The results demonstrated a generical concordance of cytology and histology in the diagnosis of malignancy equal to 95%. The concordance of exact histology was 91%. The discordance regards, above all, the malignant neoplasm and particularly the mucoepidermoide and the adenoid cystic carcinoma. Fine needle aspiration demonstrates absolute specificity in the differential diagnosis between parotid and extraparotid pathology.

Adenoma, Pleomorphic

[Complications of rhinoplasty].

For an operation as technically demanding as rhinoplasty, surprisingly few studies have examined the results of this procedure. A retrospective study was, therefore, made of 5470 patients who had undergone rhinoplasty, performed by different surgeons, from 1970 to 1989. The patients were followed up for a minimum of one year. As for all forms of surgery, aspecific complications such as infections, hemorrhage and side-effects from anesthesia will occasionally occur but, fortunately, such cases are quite rare. The specific classification included both early and late complications. Post-rhinoplasty failures may be estimated at approximately 28% of all cases; this figure taking into account typical deformities, both minor and severe, as well as functional sequelae and patient dissatisfaction. Approximately 4% have required secondary procedures. Some causes for failure derive from patient characteristics; for example, the importance and complexity of initial deformity are, of course, partly responsible, particularly after trauma. The skin quality (i.e. thickness, or whether it is fatty or loose) also affects the results. Furthermore, uncontrollable factors inherent to healing (i.e. excessive scar contraction in the intranasal area, connective tissue hyperplasia, particularly at the tip, and periosteal proliferation either to the osteotomy site or over the nasal dorsum) can all lead to residual deformities. Nevertheless, most failures can be attributed the operator. The commonest mistakes are linked to cartilaginous dorsum and nasal tip (approx. 22%). There are several polymorphic deformities the main sites of which should be known well in order to prevent, or at least reduce, such risks.

Adolescent

[Hypothyroidism following combined treatment of pharyngolaryngeal carcinoma].

The onset of hypothyroidism following surgery and/or radiotherapy for head and neck cancer varies from 25 to 67% and it is fostered by some clinical conditions. However, these percentages increase when one takes into consideration the latent hypofunctioning brought about by high levels of T.S.H. The present case study involves 15 laryngeal or pharyngolaryngeal cancer patients: 3 had undergone surgery alone although most of them had received a combination of radiotherapy and surgery. For these patients both the clinical conditions of any hypothyroidism and the laboratory parameters for thyroid function were studied. Of these the most significant proved to be T.S.H. The patients were monitored at 4 month intervals over the course of a year. In three of the 15 pharyngolaryngeal cancer subjects who had undergone a combined treatment including surgery and radiotherapy comparison of the parameters studied proved statistically highly significant (with an increase in T.S.H.). The damage sustained does not so much depend on the total dose of radiation but rather on the number of fractions employed. It may, therefore, be suggested that making changes in surgery to the detriment of oncological radicality is not worth while. It would appear that a different scheme for distribution of radiotherapy doses should, rather, be devised.

Adult