Biomedical subjects

M Duse

Publications and source records attributed to M Duse.

61 records · Page 4Linked to original sources

PubMedDate not supplied

[Use of intravenous immunoglobulins in pediatrics].

Intramuscular Immunoglobulin (IMIG) have been used for 40 years in substitution therapy for antibody deficiencies and as prophylaxis for and treatment of several infectious diseases. Modified and intact intravenous immunoglobulin preparations (IVIG) have now been available for more than 10 years: only the intact product express full Fc- mediated functions with a biological half-life of IgG (3-4 weeks). These preparations have constituted an important achievement in the treatment of humoral immunodeficiencies also resulting in a dramatic improvement of the prognosis. The use of IVIG has also modified the therapeutic approach to several secondary and acquired immunodeficiencies. Treatment with IVIG for immune modulation in several diseases is investigated: substantial data indicate a useful role in selected cases of idiopathic thrombocytopenic purpura, Kawasaky disease and in some neurologic diseases. IVIG are substantially safe and severe side effects have been rarely reported.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

[Granulocyte disorders].

The various "in vitro" tests for evaluating polymorphonuclear leucocyte function in children with recurrent infections are described and the different clinical conditions caused or accompanied by defects in polymorphonuclear function are summarized briefly. The necessity of correct interpretation of the results of the laboratory tests used in the diagnostic evaluation of patients with suspected immunodeficiency is stressed.

Agranulocytosis↗

PubMedDate not supplied

[Allergy to cow's milk proteins in childhood: the authors' personal experience and new diagnostic and therapeutic proposals].

Cow's milk protein is quite commune in infancy (2-3% in first year of age). Casein, beta-lactoglobulin and alpha-lactalbumin are the main allergens of cow's milk. The authors describe the immunological reaction involved in IgE synthesis and consequential inflammation after ingestion of cow's milk proteins and present soy and protein extensive hydrolysates as alternative diets for children with cow's milk allergy. Moreover, the authors present their studies on immunogenicity of hydrolysed formulae. At the end they suggest the therapeutic strategy in the cow's milk protein allergy.

Child, Preschool↗

PubMedDate not supplied

[The child with recurrent infections: a problem of pediatric practice].

A wide range of topics can be included under the heading of recurrent infections in children. This discussion focuses on 1) the definition of recurrent infection and physiopathogenetic mechanisms predisposing to; 2) controversies in the management of upper respiratory tract infections; 3) recurrent upper and lower respiratory infections in immunocompromised hosts, emphasizing advances in diagnosis and treatment of "mild" immunodeficiencies such as IgG subclass deficiency or antibody deficiency in normogammaglobulimia, trying to define an operative flow chart.

Child↗

PubMedDate not supplied

Expansion of large granular lymphocyte subsets in Wiskott-Aldrich syndrome.

We describe a 9-year-old boy with Wiskott-Aldrich syndrome and IgM-rheumatoid factor-positive arthritis who presented expansion of two distinct subsets (one CD8dim and the other CD8-) of large granular lymphocytes. Natural killer activity against the K-562 cell line was absent. An increased percentage of CD5+ B cells was also observed. Since patients with Wiskott-Aldrich syndrome are at risk of developing autoimmune disorders - conditions in which increased CD5+ B cells have been observed - the high percentage of CD5+ B cells together with the presence of IgM-rheumatoid factor and anti-platelet antibodies may represent an early manifestation of an autoimmune process. The possible relationship between CD5+ B cells and large granular lymphocyte expansion is discussed.

Arthritis, Rheumatoid↗

PubMedDate not supplied

[Allergy and infections: a rediscovery for pathogenesis and therapy].

The relationship between allergy and infection is well known. However only the recent discover of the mechanisms underlie to allergic inflammation gave us the interpretative key to understand the reciprocal influence. In the onset of allergic diseases infections may play whether a predisposing or protective role, while in the induction of relapses, infections play the major role, priming the inflammation, which among allergic children immediately, switches in allergic inflammation.

Allergens↗

PubMedDate not supplied

[Oxatomide in the treatment of atopic dermatitis].

BACKGROUND: This study evaluated the efficacy and tolerability of oxatomide in patients with atopic dermatitis, caused by alimentary allergy established by prick test and/or Rast and/or challenge test. METHODS: In the study, carried out in a paediatric clinic, 40 children (24 males, 16 females), aged between 6 months and 12 years, were randomized in two groups. Twenty children were treated with oxatomide (1 mg/kg/day) in one evening dose and the other 20 were treated at the same dosage, divided into two administrations. In the case of poor therapeutic response, 15 days after the start of treatment, it was possible to double the dosage. The skin symptoms were monitored for the efficacy. RESULTS: For all symptoms there was a significant reduction of severity within the fifteenth day (p < 0.01). Twenty eight children showed significant improvement with the disappearance of both cutaneous lesions and itching; to achieve these results in four cases (3 BID, 1 UID) it was necessary to double the dose (2 mg/kg/day). Eight children achieved a fair control of itching, with a slight improvement of eczema, while five children, despite the increase in dosage of the drug, did not get any substantial benefit. Three children were lost in follow-up, while in another case treatment was suspended because of the onset of an urticarious rash. CONCLUSIONS: The results confirm the efficacy of oxatomide in the control of itching connected with alimentary allergy independently of the posological scheme. Tolerability was excellent in both groups and no important side-effects were recorded.

Adult↗