[Long-term results of total surgical correction in Fallot's trilogy].
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Child↗
Biomedical subjects
M Durand
Publications and source records attributed to M Durand.
[Proposal for a new descriptive psycho-physiopathological model of schizophrenia].
We present the conclusions of a study of pattern recognition in an intermittent luminous stimulation. This stimulation was stable on the one hand and on the other hand on fixed time basis (S.L.I. pulsations emitted by two flickers) and other associated tests (reaction time, Rorschach Test, etc). We have compared a population of 30 schizophrenics (French classification) and a reference group of 53 adult subjects of both sexes. We have not divided the patients into subclasses according to their symptoms. We have noticed in a significant manner the following signs: great vigilance at the beginning, decreasing very quickly, low attentiveness, a slowness of perception and motion, a weakness in the elaboration of decision processus, certain difficulties in defining the classification of objects, a modified perception of colours, a very feeble distinction of pertinent signals and of noise, an invasion by the internal stimulus, unbalanced compared to "outside", as in sensory deprivation, a great weakness in the processus of habituation and learning, a loss of the redundancy and the constancy of the outside world (or troubles of the internal coherency, as defined by Varela). The closure, the temporal troubles (historical and present) of the integration of signals are sufficient to explain these results. A model explains the deduced hypothesis on two levels: 1) historical: the troubles of habituation and learning prevent the formation of the inner stimulus (or image, representation); 2) present: closure, ambivalence (Gödel), troubles of associations, difficulties in detecting what is pertinent, hallucinations (a "delirious" internal stimulus). The specific brain-channels seem to be normal, on the contrary the non-specific channels and the channels of integration seem troubled. The temporal trouble of "present" seems to be located on a precocious precategorical iconic level. This descriptive model does not prejudge the etiology of the disease (bibliography).
Adult↗
[Chemotherapy of head and neck carcinomas. Association of adriamycine, vincristine and methotrexate (author's transl)].
Phase II of a study of chemotherapy using adriamycine, vincristine and methotrexate is reported. Forty-six patients with carcinoma of the head and neck were treated; thirty-eight of these results can be evaluated. The degree of objective response is mainly influenced by the site of the tumour. It can vary from 8/23 to twice that figure 16/23 depending on whether the tumour is located in the territory which was previously irradiated. The mean duration of response is short, 2,5 months. The treatment seems to be quite toxic.
Adult↗
[Farmer's lung disease in the French department of Aveyron].
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Adult↗
[Salmonella aortitis complicated by rupture. Diagnostic and therapeutic problems].
We observed a case of aortitis due to Salmonella in a patient with spondylodiscitis. Outcome was fatal despite resection and grafting, extensive drainage and adapted but unsuccessful antibiotic treatment. Based on the literature, suggested treatment for patients with spondylodiscitis includes extra-anatomic bypass combined with resection of the infected tissue and adapted antibiotherapy. In these emergency cases, computed tomography is the most useful exploration and also gives the diagnosis of spondylodiscitis. It is also necessary to identify the infectious agent to adapt the antibiotics.
Aged↗
[Relations between general practitioners and cancerologists].
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Family Practice↗
Pulse oximetry in newborn infants with birth weights of 620 to 4285 grams receiving dopamine and dobutamine.
The reliability of pulse oximetry in neonates receiving inotropic drugs because of hypotension and microcirculatory perfusion failure has not been well documented. Signal loss of the pulse oximeter in adult patients receiving dopamine infusions has been reported. To evaluate the relationship between pulse oximeter oxygen saturation (SaO2) and co-oximeter directly measured oxygen saturation, we studied 30 infants in the first 4 days of life (birth weight 620 to 4285 gm, gestational age 26 to 43 weeks) receiving dopamine (30 patients) and dobutamine (10 infants). Infants had normal blood pressures at the time of the study. To minimize motion artifact a Nellcor N-200 (Nellcor Incorporated, Hayward, Calif.) oximeter with electrocardiographic synchronization was used. We compared pulse oximeter values with simultaneous arterial samples analyzed for oxygen saturation with an IL 282 co-oximeter (Instrumentation Laboratory, Inc., Lexington, Mass.). The values were corrected for spuriously elevated carboxyhemoglobin levels and fetal hemoglobin level was quantitatively measured. The partial pressure of oxygen at 90% hemoglobin saturation for each patient was calculated. The dosage of dopamine ranged from 4 to 28 micrograms/kg per minute and the dosage of dobutamine varied from 4 to 24 micrograms/kg per minute. Over a wide range of values for mean blood pressure (23 to 66 mm Hg), partial pressure of oxygen at 90% hemoglobin saturation (43.1 to 70.2 mm Hg), and oxygen saturation (SaO2 80% to 100%), linear regression analysis revealed a close correlation between pulse oximeter SaO2 and co-oximeter SaO2 values (r = 0.83, standard error of the estimate 2.2%, p < 0.0001). Our findings indicate that pulse oximetry can be used reliably for continuous oxygen monitoring in normotensive neonates with an SaO2 of 80% to 100% who are receiving dopamine and dobutamine.
Birth Weight↗
[Anticancerous chemotherapy and the general practitioner].
The evolution of anti-cancer chemotherapy has led to long duration treatments, which preferentially are given at home, with the participation of the general practitionner (G.P.). The indications and general supervision of these belong to the oncologist, so thus necessitates a coordinated effort between the many physicians. A postal inquiry has permitted the collection of the opinions of 169 G.P. (more than half of the consulted physicians) from the southwest of France, in the region depending on the Fondation Bergonié. Thus it was possible to establish the importance of this type of treatment for the majority of the G.P., the details of problems of practical application, and the value attached to the relationships with the oncologist, which need further development.
Family Practice↗