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Biomedical subjects

M Dupuis

Publications and source records attributed to M Dupuis.

105 records · Page 6Linked to original sources
PubMed1967

[Vertebrotherapy].

Explore the source record for details and available documents.

Chiropractic↗
PubMedDate not supplied

Specialized care unit: family and staff perceptions of significant elements.

Specialized care units (SCUs) for nursing home residents with dementia are increasingly prevalent. Although reported to promote positive resident outcomes, the specific characteristics of SCUs most likely to yield these outcomes have not yet been identified. This article presents the findings of a qualitative study that investigated the perceptions of family members and staff about SCU characteristics that contribute to positive outcomes for residents with dementia. All family and staff members interviewed agreed that the SCU fostered feelings of personal space, personhood, and an unforced routine. These findings are discussed and provide specific direction for care of nursing home residents with dementia.

Aged↗
PubMedDate not supplied

Generation of primary peptide-specific CD8+ cytotoxic T-lymphocytes in vitro using allogeneic dendritic cells.

Dendritic cells (DC) are potent antigen-presenting cells (APC) capable of inducing strong T-cell-mediated immunity. Infusion of lymphoma-specific antigen-loaded autologous DC has been demonstrated to result in the generation of antigen-specific immunity and reduction in tumor burden in B-cell lymphoma patients. Cellular immunotherapy employing antigen-loaded DC could have a potential therapeutic impact in tumors and viral infections, including HIV infection. However, DC in HIV-infected individuals and breast cancer patients are believed to be functionally defective. Therefore, the potential of using allogeneic DC offers significant implications for DC immunotherapy in AIDS and immunocompromised cancer patients. To explore the potential of allogeneic DC therapy in vivo, we tested the ability of allogeneic DC to generate primary peptide-specific CD8+ cytotoxic T-lymphocyte (CTL) responses in vitro. Our results indicate that DC from HLA class I-matched individuals elicit primary immune responses in vitro using viral peptides as naive antigens. A primary peptide-specific immune response could also be detected even when only one HLA allele (HLA-A*0201) was matched between the allogeneic DC and T-lymphocytes. The ability to generate primary peptide-specific responses in vitro is strongly indicative of the in vivo therapeutic potential of allogeneic DC.

Amino Acid Sequence↗
PubMedDate not supplied

[Progressive multifocal leukoencephalopathy mimicking multiple sclerosis as the sole clinical manifestation of acquired immunodeficiency syndrome].

A 38 year-old wife, of belgian origin and residency, suffered from a left retrobulbar optic neuritis in 1973, with as only sequel dyschromatopsia and central scotoma enlargement. In 1985, 12 years later, she complained of a progressive weakness of the right hand, and developed a spastic tetraplegia within four months. The C.T. Scan showed white matter hypodensities, without mass effect or contrast enhancement, first limited to the left centrum semiovale and later on with multifocal character. Somatosensory evoked potentials after stimulation of the right median nerve demonstrated only lemniscus medialis response. Multiple sclerosis was initially suspected. Analysis of lymphocytes subsets however showed a markedly reduced helper population with as a result a very low H/S ratio, and the serology was found positive for HTLV-III-LAV, thus demonstrating the diagnosis of acquired immune deficiency syndrome (AIDS). Visceral autopsy demonstrated only a CMV pneumonia. Autopsy of the brain showed typical lesions of progressive multifocal leukoencephalopathy (PML). This case is compared with 20 previously published observations of PML associated with AIDS and appears rather unusual due to the association of unfrequent clinical peculiarities: previous, probably coincidental, retrobulbar optic neuritis, female patient, lack of risk factor and clinical symptoms of AIDS. The diagnostic difficulties in the present case are emphasized.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Anatomo-clinical observation of atherosclerotic subcortical encephalopathy ("Binswanger's disease") with hypodensity of the white matter on brain scan].

A 54 year-old hypertensive female patient presented dementia evolving progressively over a four-year period in association with motor deficiency and asymmetric pyramidal signs. The scan showed diffuse hypodensity of the white matter without enhancement. Brain biopsy indicated a diagnosis of subcortical arteriosclerotic encephalopathy; this was later confirmed by the post-mortem examination. On the strength of data from the literature, the authors draw attention to the frequency of this syndrome in hypertensive patients. They outline the main clinical characteristics and demonstrate the importance of the scan.

Brain↗
PubMedDate not supplied

[Pathologies of the musculo-skeletal system in musicians].

Musculoskeletal problems are very frequent amongst musicians. The most frequent ones are tendinitis, professional cramps and dystonias, thoracic outlet syndrome, carpal tunnel syndrome, overuse syndrome and back pain. Preventive measures should included information to students about potential problems, body awareness, good physical condition, proper technique and early management of arising problems. In many cases, musicians consult only at an advance stage of their disease and a prolonged rest of the instrument is then mandatory but not easily accepted.

Humans↗