Search PubMed⌕ Search

Biomedical subjects

M Dunn

Publications and source records attributed to M Dunn.

At least 199 records · Page 11Linked to original sources
PubMed1975

Hydrostatic bladder distension - physiology and clinical application.

Studies of bladder flow during hydrostatic distention using radioactive clearance techniques and progressive diminution in blood flow as bladder pressure rises. At systolic blood pressure blood flow is minimal. Prolonged hydrostatic distention has been used as a method of therapy in those patients with urgency of urine and urge incontinence with satisfactory early clinical results and impressive changes in the cystometrogram.

Adult↗
PubMed1975

A study of the surface pH of the urinary bladder during distension in rabbits.

Bladder wall surface pH has been continuously monitored with a glass pH electrode using a simple, atraumatic technique. Experiments have been performed in the rabbit showing that there is a progressive fall in bladder wall pH as the intravesical pressure is increased. The changes in bladder wall pH serve as a sensitive indicator of bladder blood flow and so this simple method is used to assess the changes in bladder blood flow during distension.

Animals↗
PubMed1974

Changing the actions of neuroactive drugs by changing brain protein synthesis.

Diminution of cerebral protein synthesis diminished the cerebral responses of mice to some neuroactive drugs, while an increase in synthesis increased the responses. Protein synthesis in whole brains (tested in vitro) was diminished by giving living mice different inhibitors by different routes. The inhibitors tested (chloramphenicol, cycloheximide, and puromycin) diminished the behavioral responses of the mice to levodopa without affecting either its cerebral uptake or its conversion to dopamine. A diminution of the reactions of dopaminergic receptors was suggested by the diminished responses to the dopaminergic drug, apomorphine, while participation of cholinergic ones was suggested by experiments with oxotremorine. Proof that receptors had been specifically involved was secured on homogenized caudate nuclei from chloramphenicol-treated mice, in which the dopamine-activated production of cyclic AMP was markedly diminished. A stimulator of cerebral protein synthesis, the artificial double-stranded RNA, poly(I).poly(C), increased the behavioral responses to these three drugs while it increased the dopamine-activated production of cyclic AMP. Since all these experimental increases or decreases in the responses to drugs required the lapse of only a few hours, proteins with rapid turnover rates must be critical in the activation of several kinds of cerebral receptors.

Adenosine Triphosphate↗