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Biomedical subjects

M Dumitrescu

Publications and source records attributed to M Dumitrescu.

50 records · Page 3Linked to original sources
PubMedDate not supplied

[Contribution to the improvement of the results of tracheal surgery].

The authors present, in the light of their personal experience acquired in the performance of surgical interventions on the trachea (a total of 13 interventions in 11 patients), some particularities of the surgical technique, as well as of the anesthetic procedures capable to improve the immediate and the late results of these interventions. The techniques suggested are aimed at preventing the operatory risks in the surgical procedures on the trachea, which is classified by the authors in three groups: tracheal risks, vascular risks, and anesthetic risks. The validity of these techniques is confirmed by the success of the surgical procedures applied, followed by the definitive recovery of the patients which were operated with the most recent experience of the authors. Two clinical observations are presented: a case of circumferential resection of the trachea in the mediastinal portion for cicatriceal stenosis, followed by termino-terminal anastomosis, and a case of cuneiform resection of the trachea in its supracarenal section for tumoral stenosis.

Adult↗
PubMedDate not supplied

[Clinical and therapeutic aspects in perforated gastroduodenal ulcer].

A total of 591 cases were studied, with perforated gastroduodenal ulcerations, who underwent surgery in the Emergency Clinic of Bucharest in 1978-1979. Of the 591 patients 528 had duodenal perforations, 58 had gastric perforated ulcers, 4 had perforated duodenal ulcers and gastric ulcers penetrating in the pancreas, and one patient had a peptic perforated ulcer. Several factors are studied in this paper, including: age, the interval from the onset of the symptoms to hospitalization, the duration of preoperative preparations, the anatomo-clinical forms of the perforated gastro-duodenal ulcers, the type of surgical treatment, the evolution and the complications after surgery. The surgical interventions were individualized, from one case to the next, according to the general and the local condition of each patient.

Adolescent↗
PubMedDate not supplied

[Evolution of serum parameters of iron metabolism and of the natural resistance of tuberculosis patients under treatment].

The authors have studied the evolution of serum parameters of iron metabolism in patients with tuberculosis during the standard chemotherapy. The results are discussed, in the perspective of a model of natural resistance depending on iron. No strict correlation was found between the bacteriostatic capacity of the serum and the process of saturation with iron of transferrin, probably due to participation in the bacteriostatic effect of other factors beside transferrin. The results have demonstrated that the imbalance between the serum values of copper (that are increased), and those of iron (that are low) tends to become normal during the recovery, as evaluated by a negativation of the sputum cultures. These results suggest that the use of a ratio between copper and iron in the blood serum as a method for assessing the recovery of the balance in the tuberculous organism during therapy is justified.

Antitubercular Agents↗
PubMedDate not supplied

[The action of amphiphilic drugs on human fibroblasts in vitro. Their possible use in antiviral and antitumor chemotherapy].

The LDH cytotoxicity test is able to emphasize the stabilisation of human embryo fibroblast membranes, in vitro, by two amphiphilic drugs: the metomidate and the thymolol. The membrane stabilisation is emphasized by the reduced LDH externalization as compared with the untreated cells. The use of the LDH test for the selection of some natural complexes or synthetic drugs with membrane stabilising and potential antiviral activity is proposed. The inhibition of LDH by metomidate was recorded, as decreasing of the enzyme activity with increasing metomidate concentration. This fact explains the known lactic acid accumulation, under metomidate treatment of human subjects. The use of metomidate in classical cancer treatment potentiation is proposed instead of lactate externalization inhibitors, already used for this aim.

Antineoplastic Agents↗
PubMedDate not supplied

Flow cytometric study of the epirubicine accumulation modulation in the human erythrocytes by a Nocardia opaca fraction.

The effect of the "Nocardia lysozyme digest" (NLD) obtained from Nocardia opaca on the Epirubicine accumulation in erythrocytes was studied by flow cytometry. It was shown that the number of fluorescent cells increased under the NLD action due to the increased membrane permeability for epirubicine. An opposite effect was also recorded consisting in the decrease of the relative fluorescence intensity per cell. This effect was attributed to the fluorescence quenching by the oxygen metabolites produced by NDL. In this paper we present some results of the study of the NLD effect on the epirubicine (Epir) accumulation in the erythrocytes (E). It is shown by flow cytometry that the Epir accumulation in the red cells is modified by the presence of the NLD fraction.

Anthracyclines↗
PubMedDate not supplied

Modulating the expression of some biological membrane glycoconjugates by a Nocardia opaca fraction.

By some hemagglutination (HA) studies it was proved that NLD (the lysozyme digest fraction of Nocardia opaca) interacts with the Sendai virus envelope glycoproteic receptors, but not with those of the Beijing 353/89 H3N2) Influenza virus. Very likely the inhibition is due to the presence of some GAL lectins in NLD: The erythrocytes agglutinability (by the Sendai virus and by the Beijing 353/89 H3N2) Influenza virus is enhanced by their incubation with galactose.

Animals↗
PubMedDate not supplied

Biochemical and cytogenetical study of the mycoplasmal antigen and of the cyclophosphamide action in mammalians, in vivo. The action of some immunomodulatory antioxidants.

It was proved spectrophotometrically that Mycoplasma agalactiae antigen inoculated in vivo in sheep modifies the corresponding erythrocyte lysates reactivity toward methylene blue and neutral red and induces several types of chromosomal rearrangements. The treatment in vivo of sheep with an original preparation obtained from the Phaseolus vulgaris pods restores the erythrocyte lysates reactivity toward the two redox dyes and reduces the chromosomal abnormalities frequency induced by the mycoplasmal antigen. It was also demonstrated by optical and electronical microscopy that the Smise line mouse meiocytes exhibit chromosomal abnormalities induced by the cyclophosphamide treatment in vivo. In the case of concomitant treatment with the cyclophosphamide and C vitamin the same frequency of abnormalities was recorded as in the simple treatment with the drug.

Adjuvants, Immunologic↗