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Biomedical subjects

M Dugas

Publications and source records attributed to M Dugas.

At least 109 records · Page 6Linked to original sources
PubMed1980

Preliminary observations of the significance of monitoring tricyclic antidepressant plasma levels in the pediatric patient.

Plasma concentrations of clomipramine and desmethylclomipramine were monitored together with clinical effects over a period of 1--9 months in children and young adolescents (5--19 years of age) receiving clomipramine because of depressive features or enuresis. Data indicate that in the child, clomipramine is rapidly absorbed while its disposition rate is age dependent, as indicated by the significantly lower level:dose ratio (p less than 0.01) observed in the younger groups (5--10; 10--15 years). The incidence of side effects was clearly related to clomipramine plasma concentrations, whereas no relationship could be observed for the desmethyl metabolite. In the case of enuresis, a therapeutic effect was observed at clomipramine concentrations of 20--60 ng/ml, while lower or higher levels were associated with lack of therapeutic effect or adverse effects. No relationship was found between oral daily doses and clomipramine or desmethylclomipramine plasma concentrations. The data point to the usefulness of monitoring drug plasma levels in children undergoing treatment with tricyclic antidepressive drugs.

Adolescent↗
PubMed1979

Haloperidol plasma level monitoring in pediatric patients.

Plasma levels of haloperidol were monitored in children and teenagers suffering from psychotic episodes and/or abnormal movements (tics and Gilles de la Tourette's syndrome). Steady-state concentrations of haloperidol ranged from 0.7 to 19 ng/ml without any apparent relationship with the administered dose (15--285 micrograms/kg/day) and a 15-fold variability was observed for the same daily dosage. On the contrary, a significant (p < 0.02) relationship was found between the age of the patients and the plasma concentrations to dose ratios, lower values being present in younger patients. Side effects too appeared to be related to plasma levels, with a significant increase (p < 0.01) in incidence for concentrations over 6 ng/ml. In most of the cases suffering from tics and Gilles de la Tourette's syndrome, a positive response was associated with plasma levels of 1--4 ng/ml, while no relationship could be established for the psychotic group. The relevance of monitoring plasma drug levels when prescribing haloperidol in pediatrics is discussed.

Adolescent↗
PubMed1976

[Childhood aphasia with epilepsy. Remission with antiepileptic treatment].

The authors describe an example of an aphasic syndrome peculiar to children. This syndrome, which has previously been described by several authors, is characterized by an unusual form of aphasia, by its association with epileptic attacks, and by its onset in the absence of any apparent aetiology. In such cases, the effectiveness of anti-epileptic treatment on the aphasia is variable, often quite poor; on the other hand, in the case described in this report, administration of anti-epileptic treatment was followed by spectacular regression of the aphasia.

Aphasia↗