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Biomedical subjects

M Dragomirescu

Publications and source records attributed to M Dragomirescu.

80 records · Page 5Linked to original sources
PubMedDate not supplied

[Risks of therapy in infectious shock].

On the basis of their experience in the intensive therapy unit, correlated with modern pharmacokinetic data, the authors discuss the adverse effects induced by polyvalent therapy in septic shock, and which may be listed in the group of iatrogenic pathointerference. To the biochemical and functional alterations of shock may be added the possible effects of antibioticotherapy, corticotherapy, plasma expanders, lipid emulsions, crystalloid solutions, alkaline correcting solutions, osmotic diuretics, oxygenotherapy, vasoactive drugs, heparin and epsilon-amino-caproic acid. The possible summation of these effects should be indicated in the rules for observance by the medical staff of intensive therapy units.

Aminocaproic Acid↗
PubMedDate not supplied

[Current aspects of the physiopathology of the infectious process. II. Cybernetic elements in the pathogenetic structure of infectious diseases].

The authors discuss the applicability of general cybernetic principles (the theory of systems and self-regulated mechanisms based on inversed connections) to the pathophysiologic structure of infections. With reference to concrete examples they outline the following elements: the appartenance of the infectious process to the notion of system (as conceived in the theory of systems), the previsible character of the functional potential of the structured system in the components of infection, and the sequental correspondence between system dynamics and the dynamics of the infectious process. Starting from the mechanism of action of the main microbial toxins, the aptitude of the latter to act upon the functional code of the macroorganism, altering the cellular and supracellular self-regulated biosystems, is demonstrated. Finally, the practical implications of assimilating cybernetic processes in the pathophysiology of infectious diseases are analyzed.

Bacterial Infections↗
PubMedDate not supplied

[Recent studies of physiopathology of the infectious process. 3 major pathogenetic models].

With reference to recent bibliographical data and their own experience, the authors discuss the existence of three major mechanisms (models) in toxi-infectious aggression, namely: -- direct, cellular, performed by toxin-enzymes, aggressins, hemolysins, invasins, cytopathogenic effects; -- unspecifically mediated (by nervous or humoral mediators); -- specific mediators (by immune effectors, humoral immunoaggressive mechanisms or cellular induced mechanisms). The text is illustrated by examples with reference to aetiological entities than can be listed in the corresponding pathogenetic system and therapeutical lines.

Bacterial Infections↗
PubMedDate not supplied

[Current possibilities of optimizing emergency tetanus immunization].

Retrospective analysis of the tetanus cases, admitted over a six year period, shows the high risks involved by the insufficient immunoprotection. The failure of emergency immunization, with its effects on the incidence and evolution of the disease, may be accounted for by : the difficulty in establishing the vaccination past history, probable decrease of protection with time due to basal immunization, inconstant response to the booster dose, immunodepressive side effects, the drawbacks of antitoxic serum. With reference to their own experience and the published data concerning the methods applied for obtaining a more rapid response to anatoxin and possible optimizing of the protective titre concurrent with the incubation period of tetanus. Experimental investigations have demonstrated the superiority of repeated, multifocal inoculations for obtaining an earlier antitoxic immunity.

Age Factors↗