Biomedical subjects

M Dragomirescu

Publications and source records attributed to M Dragomirescu.

At least 55 records · Page 3Linked to original sources

PubMedDate not supplied

[Comparative evaluation of risk factors in acute generalized tetanus].

The investigations included a group of 26 patients with acute generalized tetanus, cared for in the Clinic according to a unitary method. A number of 17 prognostic, clinical and laboratory criteria were analyzed from the viewpoint of the pathogenic and clinicoevolutive incidence and significance. According to the severity, lethal course of the disease the following sequence was established in order of gravity: serum sickness, kypokaliemia, hyperpyruvicemia greater than an incubation of less 6 days, invasion within less than 24 hours, hyperlactacidemia greater than age over 60 years, persistent hypertension and tachycardia, hyperazoltemia, hyperglycemia, frequent paroxysmal contractions (before sedation) greater than late admission to hospital, associated cardiopulmonary pathology, hyponatriemia insufficient dressing of the wound and rural environment. The importance of the biological indices is emphasized, both as elements of prognosis and as orientative criteria for the treatment of the case.

Acute Disease↗

PubMedDate not supplied

[New coordinates in the pathogenesis of poststreptococcal nephropathies].

With reference to recently published data and the authors findings, the pathogeny and prophylaxis of streptococcal nephropathy is discussed from the viewpoint of streptococcal nephritogenicity, the reactive potential of the body and the efficiency of the antibiotic treatment. It is evident that extensive prevention with penicillin is imperfect since nephropathy, in the course of its development, is subordinated to the reactogenic immunopathological context rather than to the etiologic agent (which only becomes a link in the causattion of the disease). Today, the arguments appear to sustain a new preventive stage in which prolonged, exhaustive antibiotherapy is replaced by a differentiated etiopathogenic context, applied only in the cases of actual risk and delimited by a constant intra-and postinfectious complex clinicobiologic follow up. However, the various pathogenetic coordinates show that poststreptococcal complications demand separation of the cause which may cover the actual determining factors of the complications.

Humans↗

PubMedDate not supplied

[Pathogenicity expressed by inhibition of the Pasteur effect].

The experiments carried out demonstrate that under the influence of tetanus exotoxin, Gram-negative bacteria endotoxins, staphylococcal infection and infestation with Tr. spiralis, inhibition of the Pasteur effect occurs. Recently published data show that the same manifestation of pathogenicity is induced by diphtheria alpha and delta exotoxin, staphylococcal toxin, Pseudomonas aeruginosa exotoxin, staphylococcal enterotoxin, streptolysin O, infections with Cl. perfringens, Pasteurella and Rickettsia and hepatitis viruses in man. These data confirm a previous hypothesis according to which inhibition of the Pasteur effect represents the expression and metabolic measure of pathogenicity and toxicity. The inhibitory effect was proportional to the amount of pathogenic agent or toxin, just as the respective anatoxin or toxin + endotoxin mixture does not influence the Pasteur effect. The metabolic criteria of the Pasteur effect, i.e. inhibition of hyperlactacidaemia and decrease of the organic P/inorganic P ratio, are thus the direct indices of pathogenicity and toxigenicity. This also accounts for deep alteration of the Pasteur effect in infections generating states of infectious and endotoxinic shock.

Animals↗

PubMedDate not supplied

[Mucoproteinuria in complicated scarlet fever].

Mucoproteinuria, determined by Bugard's semiquantitative method, revealed values of 100-350 mg/24 h in common scarlet fever and of 300-882 mg/24 h in scarlet fever complicated by early nephritis, pseudorheumatism and acute diffuse glomerulonephritis. These alterations appear to lend support to the recent hypothesis concerning the mucoprotein substrate of the autoimmune mechanism in the complications of streptoccal infection.

Acute Disease↗

PubMedDate not supplied