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Biomedical subjects

M Dougados

Publications and source records attributed to M Dougados.

At least 289 records · Page 16Linked to original sources
PubMed1986

[Hormonal modulation in disseminated lupus erythematosus: the preliminary results with danazol and cyproterone acetate].

In an open prospective study, we have tested clinical efficacy and tolerance of two antigonadotropic drugs, that is danazol (D) and cyproterone-acetate (CA). This study was performed in 11 female patients ranging in age from 19 to 47 years, who suffered from midly-active SLE, during 12 therapeutic periods on the whole (that is 6 for each drug), the minimum period of which was one year. Because of side-effects, D had to be early withdrawn in 2 patients, whereas (the) AC appeared to be well-tolerated in all of them. On the whole, 16 clinical exacerbations of DLE were observed during the 12 months pre-treatment period, versus 9 exacerbations during the 12 months treatment period (p less than 0.05, Wilcoxon test), whereas the average dose of prednisone was reduced from 9.6 to 3.5 mg/day. A dramatic improvement was then observed in 3 patients suffering from mucous ulcerations. Increased plasma testosterone level without any change in estradiol level was observed in patients treated with D. Conversely, plasma estradiol decreased without any change in testosterone level in patients treated with CA. Both drugs induced reduction in plasma sex-hormone binding protein. These preliminary results suggest that D and CA may both reduce lupus disease activity, in parallel with an hormonal environment modification, towards a lower estrogen-androgen balance, along with a better tolerance as for CA.

Adult↗
PubMed1985

Hormonal modulation in systemic lupus erythematosus. Preliminary clinical and hormonal results with cyproterone acetate.

We prospectively studied the effects of hormonal modulation using the antigonadotropic drug, cyproterone acetate (CA), in 7 female patients who had moderately active systemic lupus erythematosus. CA was taken orally at a mean daily dose of 50 mg for 21-33 months by 6 patients (9 months by the seventh patient) without any side effects. The number of clinical lupus exacerbations during CA treatment was lower than that during the corresponding pretreatment period (15 of 170 patient-months versus 27 of 156 patient-months; P less than 0.05), despite a reduction in the daily maintenance dose of corticosteroids or antimalarial drugs. Mean plasma testosterone levels were low initially and remained unchanged (0.66 +/- 0.31 to 0.59 +/- 0.23 nmoles/liter), whereas plasma estradiol decreased markedly (from 0.6 +/- 0 38 to 0.11 +/- 0.03 nmoles/liter), resulting in a significant reduction in the estradiol:testosterone ratio (from 1.19 +/- 0.68 to 0.23 +/- 0.12) and in the plasma concentration of the sex hormone-binding protein. Thus, cyproterone acetate induced improvement in clinical lupus activity in parallel with the expected lower estradiol:testosterone balance.

Adult↗
PubMed1985

[Chiasmatic radionecrosis after multifractionated radiotherapy of a temporal glioma].

A 45-year-old male received split course multiple daily fractionated radiotherapy for an anaplastic left parieto-temporal astrocytoma. A total dose of 60 grays was delivered by 15 fractions of 2 grays given in 5 days and repeated after a rest period of 15 days. Forty grays were delivered to the whole brain and 20 grays to the tumor area. No surgery or radiosensitizer or chemotherapy were used at any time. The patient noted progressive loss of vision in both eyes and became blind 9 months after irradiation. Post-mortem study revealed 2 areas of radionecrosis in the chiasma and corpus callosum, corresponding to the dose of 57-60 grays. The necrotic area were at a distance of the tumor remnants. The high Daily Dose Multifractionation schedule may be responsible for the radionecrosis.

Astrocytoma↗
PubMed1985

[Course of gonococcal arthritis: a retrospective study of 42 cases].

The authors report a retrospective study of the evolution os gonococcal arthritis after antibiotic therapy. The prognosis i-good but the speed of recovery depends on early treatment. Post-septic arthritis is common (13/42) and requires local treatment. The diagnosis of post-infective and/or reactive gonococcal arthritis is discussed.

Adult↗
PubMed1984

[Study of plasma androgens in women with autoimmune diseases].

The exact significance of a reported androgen deficiency in women with lupus has not yet been determined. The authors decided to study plasma androgen concentrations not only in lupus, but also in other auto-immune diseases as well as non-auto -immune diseases. 43 patients (rheumatoid arthritis (RA): 10; systemic lupus erythematosus (SLE): 11; multiple sclerosis (MS): 11; patients without auto-immune disease: 11) were compared to 13 normal women. The age and the hormone concentrations of these different groups were compared by analysis of variance and by the Kruskal-Wallis test. A statistically significant reduction in androgen levels was only detected in the women with lupus. It therefore appears that the androgen deficiency is not a non-specific consequence of any disease, that it does not represent a predisposing factor for auto-immune disease in general, but that it is specific for lupus.

Adolescent↗
PubMed1984

The in vitro production of anti-nuclear antibodies by human peripheral blood mononuclear cells. Demonstration of T cell requirement and soluble inducing factor(s) for anti-nuclear antibodies triggering in patients with systemic lupus erythematosus.

Peripheral blood mononuclear cells (PBMC) of 29 patients with systemic lupus erythematosus (SLE) and 14 normal individuals were investigated for the in vitro production of anti-nuclear antibodies (ANA). Twenty-eight of 29 SLE patients but only one control spontaneously produced ANA in unstimulated PBMC. Pokeweed mitogen induced ANA synthesis in six controls. No detectable ANA was observed in B cell enriched fraction except in two cases of SLE. Recombination of B + T cell enriched fractions and PBMC supernatants from SLE patients could induce B cells to synthesize ANA. These results indicate that: (1) SLE patients spontaneously produced ANA in vitro whereas controls rarely did; (2) autoreactive clones exist in normal individuals but are kept under control and (3) T cell help is required for ANA triggering.

Antibodies, Antinuclear↗
PubMed1984

The in vitro production and regulation of anti-double stranded DNA antibodies by peripheral blood mononuclear cells from normals and patients with systemic lupus erythematosus.

The in vitro production of anti-double stranded DNA antibodies (anti-DNA) by peripheral blood mononuclear cells (PBMC) was investigated in 19 patients with systemic lupus erythematosus (SLE) and in 12 normal individuals, using a micro solid phase enzyme immunoassay. PBMC from SLE patients spontaneously produced anti-DNA with a higher frequency (16 of 19) than did PBMC of controls (three of 12). In addition SLE patients produced predominantly IgG antibodies. PWM and DNA enhanced anti-DNA synthesis is spontaneously low and non-producers, but acted as inhibitors in spontaneously high producers. The partial removal of T cells decreased or abolished anti-DNA synthesis in four of nine SLE patients. In contrast the B cell enriched fractions of five of nine SLE and five of seven normal patients produced the same or higher anti-DNA levels than did the corresponding unseparated PBMC. These results suggest evidence for autoreactive B cells in SLE as well as in normals, and therefore the combination of these autoreactive B cells with helper and/or suppressor T cell disorders could lead to the over production of anti-DNA seen in different patients with SLE.

Adult↗