Biomedical subjects

M Dondey

Publications and source records attributed to M Dondey.

At least 19 recordsLinked to original sources

PubMed1987

Effects of fenfluramine on the behavior of autistic individuals.

The present report, part of a national, multicenter study to investigate the effects of fenfluramine on autistic behavior, describes findings on four autistic children ranging in age from 7 to 20 years. Additional performance and parental observation measures apart from those of the multicenter study are included. Results of this study which indicated no significant side effects, a reduction in some deviant behaviors and an improvement in activity level/attention span, provide support for earlier reports. The possibility that fenfluramine's apparently positive effects might be to simply reduce inappropriate behaviors via lethargy was examined and not supported.

Adolescent↗

PubMed1983

Transverse topographical analysis of petit mal discharges: diagnostical and pathogenic implications.

The analysis, so far neglected, of the transverse distribution of the paroxysmal bilaterally synchronous activities (PBSA) of petit mal leads to differentiate two topographical varieties of discharges: a lateral variety, where the spike-and-wave patterns present two symmetrical maxima one on each side of the skull, and a medial variety, where the paroxysmal activity exhibits a maximal voltage on the midsagittal area of the scalp. In both cases the EEG patterns involve the frontal areas. In a group of 46 children, referred for petit mal, we have studied 3 main clinical parameters: the symptomatology of the absence, the evolution and the associations of the disease. This study results in the individualization of two forms of petit mal: (1) one marked by lateral discharges, simple absences, a good prognosis and non-specific associations with other epilepsies; (2) the other by medial discharges, complex absences, a poor prognosis and a high rate of associations with other forms of generalized epilepsies. The discussion is devoted to the pathogenic implications of the transverse topographical analysis of the PBSA of petit mal and more generally of bilaterally synchronous activities, paroxysmal or not, expressing physiological or pathological processes.

Adolescent↗

PubMed1982

[Topographical distribution of EEG activity induced by anesthetic agents].

Having noticed in a wide series of subjects submitted to prolonged anaesthesia that the EEG activities induced by anaesthetic products exhibited transverse topographic distributions (preferentially medial or preferentially lateral) which varied in relation to the product utilised, the authors have verified, in a more limited series of 25 subjects, that benzodiazepines, the targets of which are situated within the axial structures of the CNS, are responsible for EEG modifications which show a maximal amplitude on the parasagittal medial area of the scalp, while propanidide, which mainly affects the cortex of the convexity (i.e. the superior level of the lateral structures of the CNS), induces activities which show a maximal amplitude on the lateral areas of the scalp. The EEG modifications induced by thiopental and fentanyl are also lateralized but more diffuse. These data must be verified by a more precise study of a larger series, taking into account the dose and the speed of injection of the anaesthetic agent.

Anesthetics↗

PubMed1972