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Biomedical subjects

M Domokos

Publications and source records attributed to M Domokos.

9 recordsLinked to original sources

[Changes of authorship characteristics in Hungarian medical publications in the period of 1967-97].

Authorship characteristics of publications appeared in the 1967-1977-1987-1997 volumes of the Orvosi Hetilap (Medical Weekly) were analysed and compared with corresponding data in the international medical literature. Following results were achieved: 1. The total number of medical publications gradually decreased although the number of pages of the volumes steadily increased during the period studied; this could be explained rather by a changed structure or editorial policy than by lowering of the readiness for publishing. 2. The number of authors per paper gradually increased over a period of forty years, the same trend was observed in the world literature as well. 3. Heads of department are more and more included among the authors; previously they gave preference to the first place, presently they figure mostly as last authors. 4. As to the origin of the communications the pattern did nor change essentially: about half of the papers came from university departments, while about 20 to 30 per cent of the authors worked in hospitals; the remaining papers were the result of cooperations. 5. Both the absolute number of ratio of the dual publication of "original" articles decreased in the last twenty years; the language used for dual publication in international journals markedly changed: while in 1967 both English and German were used with the same frequency, in 1997 English was chosen in 95 per cent of dual publications.--Results were discussed rather shortly, similar studies in the international literature were cited, but authors did not intend neither to outline their's point of view nor to to take part in the current international discussion on authorship.

Authorship↗

[Involvement of the thyroid gland in clinical shock (anti-shock action of propylthiouracil)].

Propylthyouracil, a synthetic anti-thyroid drug, was given intravenously in ten patients in a severe shock condition and its action was followed on the blood cathecholamines. This was assessed in venous blood according to a modified colorimetric method by Manuhin, before and 30 minutes after the substance was perfused. Although statistically non-significantly the two amines show a tendency to fall after the administration of the drug. In line with a series of previous studies carried out in various institutes of chemical and pharmaceutical research the drug was given for the first time in humans in shock conditions. Discussing the results obtained the administration of propylthyouracil is recommended, as an adjuvant therapy in severe shock.

Adrenal Glands↗

Experimental preparation of deantigenized vascular heterografts and study of tolerance after transplantation.

A new technique in preparing a heterograft is presented. Deantigenized calf carotid arteries are obtained by papain digestion and formol tanning. The biochemical determinations show a pronounced reduction in total protein content after papain digestion. The formol tanning gives a good rigidity and elasticity in adapting to different blood volumes without aneurysmal dilatation. Eight dogs were grafted : two died after surgery, two were killed after 35 days and two others 60 days after transplantation, one died after 8 months and one is alive 30 months after transplantation. The good in vivo tolerability has been appreciated. There have been no haemodynamic troubles and no cell changes of rejection. An insignificant quantity of immunoglobulins G has been found in the sera of the animals with heterografts. These data draw attention on the possibility of the use, in clinical practice, of the deantigenized calf arteries.

Animals↗

[Pathogenetic aspects of acute renal insufficiency in experimental acute pancreatitis].

The authors carried out a study of some pathogenic mechanisms related to the development of acute renal failure in animals following pancreatitis-induced shock. The study was made in 110 white rats in which acute pancreatitis was induced experimentally, and the results were compared with those obtained in a control lot of 40 rats. The behaviour of some biochemical parameters was investigated (cathecholamines, acid phosphatases, catepsine, aminoacids and polypeptides), in tissue homogenates (liver, intestine and kidney), and in the serum. Histopathologic changes were also evaluated, which occurred in the intestine, the kidney, the liver and the pancreas. Histopathologic changes in the kidney, and acute renal failure which accompanied them in rats with acute pancreatitis are rather a result of protesic activation in the tissues of the organs involved (especially the intestine and the kidney), and are less the results of enzymatic extension or metastases following pancreatic necrosis.

Acute Disease↗