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Biomedical subjects

M Doherty

Publications and source records attributed to M Doherty.

At least 235 records · Page 13Linked to original sources
PubMed1986

A reappraisal of 'analgesic hip'.

Nineteen patients with hip radiographs typical of 'analgesic hip' (rapidly destructive, atrophic arthropathy involving both femoral and acetabular components) have been studied. Women predominated (14:5), and all were elderly (mean age 74 years, range 64-83 years). Destructive hip disease was unilateral in all but one case. The mean interval from symptom onset to typical x ray appearance was short (one year, range three to 24 months), and persistent pain unresponsive to drug therapy was characteristic. Screening showed no metabolic or neurological disease. Contrary to previous reports, non-steroidal anti-inflammatory drugs could not be incriminated in development of the disease. Clinical and radiographic similarity to apatite associated destructive arthritis of other large joints was striking, and occurrence of the latter, uncommon condition in five patients (five shoulders, two knees) suggests that both descriptions represent a common articular response at different joint sites.

Aged↗
PubMed1986

Acute phase response and mastitis in the cow.

The levels of three plasma proteins, which are classed as acute phase reactants, were compared in a group of cows which suffered from mastitis with those in a group of cows which were clinically normal. The plasma levels of haptoglobin, ceruloplasmin and alpha 1 antitrypsin were higher in the cows with mastitis than in normal cows.

Animals↗
PubMed1985

A comparison of normal and pathological synovial fluid.

Synovial fluid from 16 normal subjects was compared with that from 149 patients with a variety of rheumatic disorders. Normal fluid had fewer cells and a lower content of beta-glucuronidase than osteoarthritic samples. Particles, including occasional birefringent crystals, were seen in normal fluids as well as pathological samples. Alizarin red staining particles (presumed to contain apatite) were seen in all diagnostic groups; their numbers showed some correlation with radiological calcification in and around the joints and with a hypertrophic subchondral bone response. Lactate levels were highest in septic arthritis. No assay showed disease specificity.

Adult↗
PubMed1985

Multiple microcrystal deposition within a family.

A family is described in which four members in three generations showed evidence of crystal deposition disease: two developed calcium pyrophosphate dihydrate (CPPD) crystal deposition, one calcific periarthritis, and one mixed crystal deposition disease (gout + chondrocalcinosis). This previously undescribed observation supports a possible role for nonspecific heritable connective tissue factors in predisposing to crystal deposition.

Adult↗
PubMed1984

Low incidence of calcium pyrophosphate dihydrate crystal deposition in rheumatoid arthritis, with modification of radiographic features in coexistent disease.

A negative correlation between rheumatoid arthritis (RA) and calcium pyrophosphate dihydrate (CPPD) crystal deposition was demonstrated in separate controlled radiographic and synovial fluid surveys of RA patients aged 55-75 years. Knee chondrocalcinosis was detected in 14% of 135 normal controls and 28% of 87 post-meniscectomy ("joint damage") controls (P less than 0.05), but only 3% of 100 RA and 75 osteoarthritis patients revealed CPPD crystals in 1% and 23%, respectively (P less than 0.01). Ten subjects with coexistent RA and CPPD deposition were also studied; 7 showed radiographic features atypical of RA, including patchy, asymmetric disease, retained bone density, prominent osteophytosis, well-corticated cysts, and paucity of progressive erosive disease. It is suggested that rheumatoid joint damage, unlike that in osteoarthritis, is not conducive to CPPD crystal formation. When RA and CPPD coexist, atypical radiographic features reflecting a hypertrophic reparative response may occur.

Aged↗
PubMed1984

Apatite associated destructive arthritis.

Twelve patients, 11 women and one man, aged 66-83, with a distinctive type of destructive arthropathy are described. The principal joints affected were the shoulders (ten) and knees (seven). Clinical features included pain on use, large cool effusions, instability and rapid progression. Radiographs showed attrition of bone and cartilage with a paucity of reparative changes. Synovial fluids were viscous, with low cell counts, and stained positively for the presence of apatite-containing particles. Extensive calcific material was seen in the synovium of the four patients biopsied, and on the radiographs in seven. Most patients had some associated or preceding joint disorder. The literature on similar cases is reviewed, and the possible role of crystals and other aetiological factors is discussed. It is suggested that a characteristic form of large-joint atrophy can occur in elderly patients at a number of joint sites and in several different clinical settings.

Aged↗
PubMed1984

Pyrophosphate arthropathy as a late complication of juvenile chronic arthritis.

Pyrophosphate arthropathy is an age-related disease rarely seen in those under 45 years of age. We report 2 patients with early onset pyrophosphate arthropathy in joints previously affected by juvenile chronic arthritis. This previously undescribed association supports the hypothesis that joint damage may predispose to calcium pyrophosphate dihydrate crystal deposition and lead to secondary pyrophosphate arthropathy.

Adult↗
PubMed1984

A new technique for ovarian transposition.

A technique of ovarian transposition is presented. The major modification of other techniques is the retention of the ovarian vascular pedicle in the retroperitoneum while placing the ovary intraperitoneally. The primary purpose of this technique is avoidance of castration due to radiation in women being treated for carcinoma of the uterine cervix.

Adult↗
PubMed1983

Influence of primary generalised osteoarthritis on development of secondary osteoarthritis.

The hands and knees of 150 patients who had undergone unilateral meniscectomy 19 or more (mean 24 . 7) years before were examined for evidence of osteoarthritis (OA). 65 had X-ray changes in the hands consistent with primary generalised OA. These patients showed more frequent and more severe knee OA, judged clinically and radiologically, in both unoperated and operated knees, than did the 85 patients without hand OA. The increased frequency in operated knees was independent of sex and age variables between the groups and remained significant after exclusion of patients with OA on the unoperated side. This study demonstrated that predisposition to "primary" OA influences the development and severity of "secondary" OA. It invalidates clear distinction between these subsets and emphasises the multifactorial nature of the disease.

Adult↗
PubMed1983

Activation of the alternative pathway of complement by monosodium urate monohydrate crystals and other inflammatory particles.

Activation of serum C3 by monosodium urate monohydrate (MSU) crystals and other particles was determined by immunofixation following electrophoretic separation of C3 and its activation products. Densitometry allowed quantitation of results. MSU, hydroxyapatite, brushite, and calcium pyrophosphate dihydrate crystals split C3 under conditions which demonstrate activation via the alternative pathway (AP). Quantitatively similar results were obtained in immunoglobulin deficient serum. Activation was crystal specific and was reduced by heating, grinding, sonication, and aging of crystals. Other inflammatory particles (e.g., blackthorn) activated C3 via the AP: noninflammatory particles (e.g., diamond) caused insignificant activation. It is suggested that particle-induced activation of the alternative pathway of complement may be important in the initiation of crystal-induced synovitis.

Agammaglobulinemia↗