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Biomedical subjects

M Dimitrova

Publications and source records attributed to M Dimitrova.

34 records · Page 2Linked to original sources

[New epidemiological study data on the manufacture of divinyl].

Complex labour-hygienic studies were carried out on the working environment in divinyl production as well as on the health state of the workers. The leading deleterious factor of the environment are the concentrations of divinyl, hydrocarbons and ammonia above the norms. The latter have been determined by stationary and personal sample collecting. More than half of the workers examined work under labour conditions characterized as "particularly unfavourable" and "dangerous". In comparison with the hygienic characteristic by the middle of 1978-1980, a considerable increase of ammonia concentrations was established. A total of 102 workers have been covered by a complete clinical-laboratory examination. The results have been statistically processed with a view to establishing the correlation between the effect of the deleterious factors of the working environment and the deviations established in the health state of the workers. The following cases could be associated with occupational risk: cases with "positive" and "very likely" chronic ischemic heart disease as well as those with arterial hypertension, gastrointestinal diseases, chronic diseases of upper respiratory pathways with loss of sense of smell to various degrees, the neurological diseases--autonomic-vasal and neurotic syndrome, the cases of contact dermatitis and anemic syndrome.

Adult↗

[Results of a longitudinal study of coronary diseases in occupational exposure to carbon disulfide].

A seven-yer longitudinal study was carried out on the risk of coronaropathy origination in workers, exposed to increased carbon sulphide concentrations. Increased number of the subjects with manifestations of positive and probable IHD was observed among those exposed no increase was observed among the controls. The significance of carbon sulphide as a basic and potentiating risk factor to smoking and hypertension cannot be still determined.

Adult↗

[Effect of wide-band modulated electromagnetic fields on the workers of high-frequency telephone exchanges].

Physiological examinations of 63 subjects were performed as well as clinical, functional, paraclinical, etc. examinations of 82 subjects working under the effect of wide-band modulated electromagnetic fields in HFA of telephone exchanges. Some physiological changes were found as regards the level of blood pressure and auditory threshold. Though the intensity of EMF were within the allowable limits, changes in the neuro-vegetological state, genital sphere, were found in some of the examined workers as well as in immunologic reactivity and some paraclinical indices, described to develop under electromagnetic effect, attributed to the specificity of EMF-wide-band, modulated.

Adult↗

[Occupational injuries to workers in contact with carbon disulfide].

Results are reported of a planned prospective longitudinal study of the early phases of angiopathy and other clinical, clinico-laboratory and functional changes in the early period of carbon disulphide effects. Subject of the study were 251 workers employed in artificial fiber production; in 73 of them the complex investigations were repeated within an interval of 3 years. The studies demonstrated the presence of distinct vascular, vegetative and irritative changes. They were low-grade ones, of no particular interest, especially the vascular ones, as they were demonstrable after comparatively short exposure to carbon disulphide and in young age.

Adult↗

[Experimental study of the dynamics of alkaline phsophatase activity after a liver wound].

The investigation of alkaline phosphatase activity on 80 rabbits with an experimental model of liver wound showed the following results: 1. Alkaline phosphatase in blood serum was elevated considerably during the first postoperative days, but after the fifth day was close to the normal ranges. 2. Tissue alkaline phospatase sharply fell up to the third day. Its values began to raise after the 20th day and reached the normal level in the end of the experimental period (30th day). 3. Histochemical studies of liver wound showed a positive reaction for alkaline phosphatase in the cells of the inflammatory infiltrate during the first days. Increased phosphatase activity was demonstrated in fiber structures, epithelium of bile canals and capillary endothelium. The dynamics of alkaline phosphatase activity in blood serum is a reflection of the delicate biochemical and histochemical changes in the liver wound. The follow-up of serum alkaline phosphatase together with the clinical course of healing could be an useful index for evaluation of diet and working capacity of the patient.

Alkaline Phosphatase↗

[Biochemical characteristics of soluble collagen in glued and sewed liver wounds].

The author examined soluble fractions of collagenalkaline soluble, acid soluble and neutral soluble in sewed and glued with cyanacrylic glue experimental wounds of liever in rabbits. The operative wounds were treated as regenerating tissues with various metabolism in respect to the soluble collagen. There was higher percentage ratio of the fractions revealing the synthesis of the collagenous molecule and the formation of colagemous fibre in the sewed wounds.

Animals↗

Integrity of endothelium in cryopreserved human cornea.

The aim of the present study was to elaborate an optimal method for cryopreservation of human donor cornea for transplantation and to follow the morphological changes in the structure of the endothelial cell layer using scanning electron microscopy (SEM). Sixteen groups, with four donor cornea each, were cryopreserved at cooling rates of 1 degree C per min and 5 degree C per min. Four cryoprotectants (glycerol, dimethyl sulfoxide, 1,2-propanediol, polyethylene glycol-400) in two concentrations (5% and 10% v/v) were prepared on the bases of medium Optisol GS supplied with 20% v/v human serum albumin. Four additional human cornea were used as controls. Endothelial cell recovery of the cornea after thawing and 24 hours culture, was calculated as a percent of the preserved recovered cells. Sufficient recovery of the endothelial cell layer, making the cornea suitable for transplantation was obtained using the cryoprotectants dimethyl sulfoxide and especially polyethylene glycol-400.

Adult↗