Biomedical subjects

M Dichgans

Publications and source records attributed to M Dichgans.

38 records · Page 3Linked to original sources

PubMedDate not supplied

Differential diagnosis of CNS lesions in AIDS patients by FDG-PET.

OBJECTIVE: The aim of this study was to evaluate the potential of FDG-PET in the differential diagnosis of CNS lesions in patients with AIDS, particularly to differentiate between toxoplasmosis and lymphoma. MATERIALS AND METHODS: We examined 11 AIDS patients, 6 with toxoplasmosis, 1 with a tuberculoma, and 4 with a primary CNS lymphoma. The FDG uptake within the lesion was compared with the uptake in a contralateral brain area [standardized uptake value (SUV)]. RESULTS: In all subjects with cerebral infections (toxoplasmosis, tuberculoma), the SUV ratio was significantly (p < 0.05) lower than the SUV ratio in patients with lymphoma (range of 0.3-0.7 vs. 1.7-3.1) with no overlap of the uptake values. CONCLUSION: In conclusion, FDG-PET may help to characterize these lesions metabolically and play an important role in the clinical management of AIDS patients with CNS involvement.

AIDS-Related Opportunistic Infections↗

PubMedDate not supplied

APP expression in primary neuronal cell cultures from P6 mice during in vitro differentiation.

Primary neuronal cell cultures from P6 mice were investigated in order to study amyloid protein precursor (APP) gene expression in differentiating neurons. Cerebellar granule cells which strongly express APP 695 allowed the identification of three distinct isoforms of neuronal APP 695. The high-molecular-weight form of APP 695 is sialylated. The expression pattern of neuronal APP 695 changes during in vitro differentiation. Sialylated forms become more abundant upon longer cultivation time. The secreted forms of sialylated, neuronal APP 695 are shown to comigrate with APP isolated from cerebrospinal fluid. We suggest that the different sialylation states of APP 695 may reflect the modulation of cell-cell and cell-substrate interactions during in vitro differentiation and regeneration.

Amyloid beta-Protein Precursor↗