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Biomedical subjects

M Di Summa

Publications and source records attributed to M Di Summa.

At least 55 records · Page 3Linked to original sources

[Aortic coarctation and aneurysms of the ascending aorta].

Dissection and rupture of the aorta account for 20% of death in the natural history of aortic coarctation. We describe here in four patients in whom an ascending aortic aneurysm was associated with aortic coarctation. Three patients had aortic valve incompetence. In two cases there was a dissection. This had not been recognized preoperatively in one, in whom the intimal tear was small; in the other patient, with dissection and shock, the associated mild coarctation was demonstrated only at autopsy. Surgical treatment of patients with aortic coarctation and associated aortic aneurysm must include resection of both the stenotic isthmus and dilated section of the aorta, because of a documented poor prognosis. Furtherly, when evaluating patients with aortic dissection a coexisting coarctation although infrequent must be ruled out. If such an association is identified in emergency cases the dissected aorta should be repaired first, employing a suitable technique (double arterial cannulation, above and below the isthmus) in order to ensure adequate perfusion. When there is no acute dissection, repair of the coarctation should be undertaken first.

Adolescent↗

[Left atrial myxoma and calcified aortic stenosis in a patient with syncope].

A 59-year-old man who suffered several episodes of syncope had both calcific aortic stenosis and a left atrial myxoma. As syncope occurred during effort, rather than after postural changes, we believe that the symptom was caused by aortic stenosis. In fact the myxoma was only mildly obstructive both by haemodynamic measurements and at visual inspection at surgery.

Aortic Valve Stenosis↗

[Right atrial myxoma. Review of the literature and a case report].

On the basis of a personal observation and from a complete review of the existing literature, clinical and instrumental findings of right atrial myxoma are described. The clinical presentation appears to be rather characteristic. The presence of systemic symptoms, peripheral venous hypertension and/or right heart failure without apparent cause are a clue to the diagnosis especially in an adult woman. The presence of abnormal sounds and/or murmurs in the tricuspid area and intermittence of the signs of obstruction are further support to the diagnosis. The diagnosis can always be made non-invasively by echocardiography, though some pitfalls seem to be inherent to the M-mode technique. The accuracy of two-dimensional echocardiography in the diagnosis of the right atrial myxoma is such that no further investigations are necessary before surgery.

Echocardiography↗

[Myocardial protection from cardioplegic and hypothermia during aortic cross-clamping (author's ttrans)].

The clinical results with cardioplegic solutions and hypothermia during aortic cross-clamping are compared with the clinical results obtained with hypothermia only. To complete the study miocardial biopsies were obtained during aortic cross-clamping in order to evaluate the concentration of ATP and CPK. The obtained data confirm the effectiveness of the myocardial protection.

Adenosine Triphosphate↗

[The administration of an association of sodium nitroprusside and adrenaline in cardiac surgery (author's transl)].

In 223 operations of cardiovascular surgery, myocardial performance was supported, after the interruption of cardiopulmonary bypass, by means of a combined and strictly controlled administration of a pure vasodilator drug (sodium nitroprusside) and of an inotropic agent (epinephrine). The reduction of afterload achieved by the former, the increase of contractility and heart rate induced by the latter, the coronary dilator effect of both, associated with an adequate maintaining of preload proved to be rapidly effective. This appeared to be particularly true in patients with overt left ventricular failure after valve replacement and/or myocardial revascularization procedures. The proposed association of drugs and treatment program seem to be an appropriate way of managing the myocardial and hemodynamic response to the metabolic reactivation that follows the surgical ischemic cardiac arrest.

Cardiac Surgical Procedures↗

[The biological prostheses of Hancock in our experience of 250 subjects underwent a valvular replacement (author's transl)].

In this study we present the results of 5-years Follow-up of Clinical experimentation with biological prostheses of Hancock in 250 patients underwent a valvular replacement at the Cardiovascular Surgery Institute of Padua University in Verona. We report the immediate and long-term results with the death causes and the complications related above all with thrombo-embolic events. For such complications it was done a comparison relatively to the cases with mitral and aortic prostheses, with the results obtained from another Cardiovascular Surgery Center where are always applied artificial prostheses. From this comparison results that Hancock's biological prostheses has a major tendency to give incidence of embolic in the first months following the valvular replacement, but successively it is clearly to be prefered to artificial prostheses.

Evaluation Studies as Topic↗

[Coronary fistula in the right ventricle].

A case of fistula between the left coronary artery and the right ventricle in a girl aged 14 months is described. The description of the case deals with the semeiological classification of cardiocoronary fistulas, the means of investigation and differential diagnostics. The therapy is purely surgical and consists in isolation, ligature and dissection of the anomalous coronary.

Coronary Vessel Anomalies↗

Coronary artery bypass grafting for unstable angina. Risk factors of operative mortality.

In order to identify factors affecting early mortality in patients undergoing CABG for unstable angina, several risk factors have been analysed in a group of 120 patients. Systemic hypertension and left ventricular impairment were shown to be significant risk factors (Systemic hypertension, P less than 0.01; EF less than or equal to 0.35, P less than 0.01; LVEDP greater than or equal to 20 mmHg, P less than 0.025). Overall mortality rate was 5% (6/120). No influence could be recognized for age, sex, previous MI, emergency surgery, extension of coronary disease, completeness of revascularization and mode of onset of symptoms.

Adult↗