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Biomedical subjects

M Di Biase

Publications and source records attributed to M Di Biase.

At least 55 records · Page 3Linked to original sources
PubMed1976

[Prinzmental's angina and disturbances of the stimulus conduction (author's transl)].

Our series (30 cases) of variant angina as well as the reports from literature, were reviewed, to investigate the consequences of an acute regional ischemia on seno-atrial, atrio-ventricular and intraventricular conduction. Sinoatrial conduction was never affected independently from the anterior or posterior localization of the ischemia. A junctional impairment of atrio-ventricular conduction was rather frequent in cases of variant angina affecting the inferior wall, ranging in different series from 8% to 25%. Only one case of bundle branch block was observed. Hemiblocks were found to be extremely rare, while a deviation of the main axis of the QRS on the frontal plane, especially to the left in cases with anterior localization of the ischemia, was observed quite frequently. This axis deviation, in the absence of changes of the initial vector of the QRS compatible with the diagnosis of hemiblocks, were considered to be depending on a parietal block.

Angina Pectoris↗
PubMed1976

[Mitral valve prolapse and the ventricular pre-excitation syndrome (author's transl)].

One of the most important clinical aspects of the mitral valve prolapse syndrome is the high incidence of arrhythmias. Some recent reports on the association of mitral valve prolapse with ventricular pre-excitation may be relevant to the understanding of such arrhythmias. In order to evaluate the clinical relevance of this association, all patients with proven idiopathic mitral valve prolapse who came under our observation during the last twelve months, were submitted to careful electrocardiographic examination with the aim of detecting even subtle degrees of pre-excitation. His bundle recording and programmed atrial stimulation were performed if there was any suspicion of a delta wave. The association with ventricular pre-excitation was proved in 6 out of 41 examined cases. The main clinical, phonocardiographic, echocardiographic, angiographic and electrophysiologic data, as well as the familial study of these cases, are presented. The need for electrophysiologic study in some cases with doubtful electrocardiographic pattern is pointed out. While previous reports only described cases with left-sided accessory pathways, examples of right-sided pathways are presented in our series. The high incidence of mitral valve prolapse, and especially of pre-excitation syndrome and arrhythmias in the familial study, suggests that the association is not an occasional one. The detection of ventricular pre-excitation in cases of mitral valve prolapse complicated by recurrent tachy-arrhythmias may be of practical importance for an appropriate therapeutic approach.

Adult↗
PubMed1976

[Coronary spasm and acute coronary insufficiency (author's transly)].

A series of cases illustrating a spectrum of acute coronary episodes associated with transient subepicardial injury, namely the variant form of angina, angina intermedia with electrocardiographic changes similar to those of the variant angina, acute myocardial infarction complicated by variant angina with electrocardiographic changes localized to the infarcted area, acute myocardial infarction preceded and followed by variant angina, is presented. The role of a coronary spasm as a common mechanism of the above mentioned episodes is postulated. Coronarographic demonstration of this mechanism is produced.

Adult↗
PubMed1975

Left posterior hemiblock in acute myocardial infarction.

Fifteen cases of left posterior hemiblock associated with acute myocardial infaction were studied. In 5 cases the left posterior hemiblock was the only intraventricular conduction defect, while in the other 10 cases it was associated with complete right bundle-branch block. Left posterior hemiblock proved to be an early complication, appearing within a few hours from the onset of the acute episode, and an ominous sign, since hospital mortality rate was 87 per cent. Cause of death was mainly pump failure. In most of these cases ther was electrocardiographic evidence of infarction involving both anterior and inferior ventricular walls. Infarction of most or all of the ventricular septum was a common finding in the cases examined anatomically. Histologically, acute changes involving mainly the posterior septal and midseptal fibres were observed in 6 of the 8 cases studied. On the basis of these findings and of other published findings an alternative physiopathological mechanism for so-called left posterior hemiblock is proposed.

Acute Disease↗
PubMed1975

[Interatrial block with retrograde activation of the left atrium (author's transl)].

Six cases with P wave abnormalities compatible, according to the criteria of Castillo and Vernant, with the diagnosis of block of the Bachmann's bundle, have been studied by means of intra-atrial and esophageal electrography. In two cases the P wave abnormalities were intermittent. In agreement with the results of Castillo and Vernant right atrial activation appears to be normal and coincides with the initial positive deflection of the P wave in leads II, III, and aVF. Left atrial activation starts at the end of the right atrial activation, coinciding with the terminal negative deflection of the P wave in leads II, III, and aVF and shows an abnormal progression from the lower part to the upper part of the atrium. This pattern of atrial depolarisation can only be explained by a block of the superior interatrial pathways. On the basis of the present findings it is supposed that the block occurs in a specialized type of atrial tissue rather than in the common atrial myocardium. From the clinical point of view it is of some interest to point out that this abnormal pattern of atrial depolarisation does not necessarily prolong the atrial deloparisation and may not determine a terminal negative deflection of the P wave in lead II.

Adult↗
PubMed1975

[Electrophysiological bases of the antiarrhythmic activity of amiodarone (author's transl)].

The electrophysiological effects of orally administered Amiodarone (600 mg daily for 8 days) were evaluated using His bundle electrograms, the extrastimulus method and atrial pacing in 16 patients with proved ischemic heart disease. Our results show that Amiodarone: 1) does not affect sinus node activity; 2) considerably prolongs the refractory periods of the atrium; 3) slightly and inconsistently prolongs the refractory periods of the atrio-ventricular node and the intraventricular conduction system; 4) slightly decreases the atrio-ventricular conduction; 5) does not consistently depress the intraventricular conduction. These properties contribute to the explanation of the antiarrhythmic effects of the drug.

Adult↗