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Biomedical subjects

M Deveaux

Publications and source records attributed to M Deveaux.

48 records · Page 3Linked to original sources
PubMed1987

[Results of scintigraphy with m-[123I]iodobenzylguanidine in neuroblastoma in children].

From 46 [123I]m IBG scans performed in 33 children, excellent specificity (96%) and good sensitivity (90%) appeared in the detection of neuroblastoma; less differentiated non catecholamine-excreting tumours remained undetected. As any localization to be seen was clearly visualized on the 24-h scan, the use of the [123I]m IBG (p, 5n) is recommended for the diagnosis, staging and follow-up of neuroblastoma in children.

3-Iodobenzylguanidine↗
PubMedDate not supplied

Contribution of scintigraphy to verify the reliability of different preparation processes for enteric coated capsules.

The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resistant in gastric fluids and soluble in intestinal zones. Results are well correlated with those previously obtained in vitro (disintegration, dissolution) and in vivo (profiles of plasmatic concentrations versus time).

Acetaminophen↗
PubMedDate not supplied

Intestinal permeability to [51Cr]EDTA in children with Crohn's disease and celiac disease.

[51Cr]EDTA was used as a probe molecule to assess intestinal permeability in 7 healthy control adults, 11 control children, 17 children with Crohn's disease, and 6 children with untreated celiac disease. After subjects fasted overnight, 75 kBq/kg (= 2 microCi/kg) 51Cr-labeled EDTA was given by mouth; 24-h urinary excretion of [51 Cr]EDTA was measured and expressed as a percentage of the total oral dose. Mean and SD were as follows: control adults 1.47 +/- 0.62, control children 1.59 +/- 0.55, and patients with Crohn's disease or celiac disease 5.35 +/- 1.94. The difference between control children and patients was statistically significant (p less than 0.001). These results show that intestinal permeability to [51Cr]EDTA is increased among children with active or inactive Crohn's disease affecting small bowel only or small bowel and colon, and with untreated celiac disease. The [51Cr]EDTA permeability test could facilitate the decision to perform more extensive investigations in children suspected of small bowel disease who have atypical or poor clinical and biological symptomatology.

Administration, Oral↗
PubMedDate not supplied

[Judicial expertise in blood alcohol determination and toxicological analysis].

Blood alcohol determination or toxicological expert evaluation are a part of the judicial inquiry. They are devoted to authorized professionals registrated by the court of appeal and they are obliged to perform themselves the analysis. They bind the civil and penal liability of the professionals who are designated. After a reapparaisal of the French legislation concerning blood alcohol levels, the authors review the totality of problems resulting from the interpretation of results as well as the relationship to judicial authorities: expert nomination procedure, professional criterions, legal points, daily practice. Among usual questions from magistrates and policemen, the expert has to estimate the quantity of alcohol taken by an individual, evaluate the blood ethanol content of a subject when the blood collection is late, calculate blood ethanol from breath alcohol analysis. For forensic toxicology, professional criterions and legal aspects are also touched on.

Breath Tests↗
PubMedDate not supplied

[Value of systematic toxicological analysis in the management of drug addicts].

This study was carried out between March and December 1985, on 50 drug addicts, including 45 heroin users, hospitalized for detoxication. We compared the clinical informations obtained at the time of admission with the toxicological informations obtained from blood and urinary samples. If the drugs said to have been used over the last 48 hours are always found, in 52% of these cases some other drugs are found too. The reasons of this difference between clinical and toxicological informations are analysed as well as their consequences on diagnosis and treatment. This data finally shows the importance of systematic toxicological analysis in the treatment of drug addicts as well as in the epidemiological studies.

Adolescent↗