[Treatment of infarction in the acute phase].
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Biomedical subjects
Publications and source records attributed to M Demeester.
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A system suitable for prolonged continuous in vivo measurement of human arterial PO2 is described. The system uses a polarographic electrode developed by Kimmich and Kreuzer, inserted in a specially made shunt between the radial artery and an antecubital vein. Nhe electrode surface is maintained in a fixed position parallel to the flow of blood; blood velocity dependency is small owing to the high flow rate achieved (more than 40 cm/s); clotting is prevented by the material used and the continuous instillation of heparin through the arterial end of the shunt. The system has been tested in vitro; it is stable (variation less than 0.5% in 24 h), linear and precise (plus or minus 0.2%) in a broad range of PO2 values (from about 10 mmHg to more than 700 mmHg); its response time is 0.4 s per 95% of deflection. It has been applied to 35 patients for periods ranging between 6 and 24 h; most of the patients were ventilated by an Engstrom respirator.
The structure of the respiratory monitoring system under construction in Brussels University Hospitals is described. It is modular and hierarchized. It is based on the observation of the lung mechanics, of the flows of inspired and expired gases and of continuous blood measurements in patients artificially ventilated. Respiratory monitoring may be confined to the continuous observation of the natural evolution of a large number of parameters and the extraction of the most possible information with the aid of automatic calculations effected in real time. The authors propose to add deliberate and controlled aggressions of the pulmonary system in order to observe its dynamic behavior. Practical function tests are described. They lead to the calculation of functional residual capacity, continuous distribution of tidal volume, and pulmonary capillary blood flow. These tests can be performed automatically by using a new electronic unit built in our laboratory. It enables a digital computer to control the functioning of a commercially available ventilator.
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