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M Demedts

Publications and source records attributed to M Demedts.

258 records · Page 15Linked to original sources
PubMedDate not supplied

Bronchioloalveolar carcinoma: long-term survival of 23 resected patients.

We studied 23 patients, who underwent resection for bronchioloalveolar carcinoma between 1975 and 1992. The predictive value of the radiologic features, TNM staging, histopathologic type and extent of resection were examined. There were 20 men and 3 women (13%) with a mean age of 58 years (32-72y). Of all patients, 18 (78.3%) were asymptomatic. At chest X-ray, 14 (61%) revealed a solitary nodule, 6 an infiltrative or pneumonic mass, one a cystic lesion, and two multinodular lesions. The actuarial five-year survival was 46 +/- 23%. When a lobectomy was performed for bronchioloalveolar carcinoma, survival was better than when a pneumonectomy was performed. None of the seven patients who underwent a pneumonectomy survived 5 years. The actuarial 5-year survival of the 16 lobectomies was 70 +/- 25%. There was no statistical difference in survival between the histopathologic types.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

Isolated lung transplantation; initial experience at the University Hospitals Leuven. Leuven Lung Transplant Group.

Lung transplantation nowadays has become a therapeutic modality in the treatment of patients with a variety of end-stage lung diseases. Between July 1991 and December 1992, twelve patients received an isolated lung transplant (eight single lungs and four double lungs) at the University Hospitals of Leuven. The indication for transplantation was emphysema in five patients, pulmonary fibrosis in three, cystic fibrosis in three and primary pulmonary hypertension in one. There were four early, in-hospital deaths (30%): two from sepsis and multi-organ failure, one from anoxia following a bronchial dehiscence and another patient exsanguinated following stent insertion for a partial bronchial dehiscence. Three more patients have died during follow-up: two from chronic respiratory failure secondary to the development of obliterative bronchiolitis (one at 8 months and one at 17 months), and one from a late bronchovascular fistula 4 months following transplantation. The overall actuarial one and two year-survival was 50.0% and 41.6% respectively. All patients discharged from hospital were oxygen free with an improved lung function and exercise capacity. We conclude that lung transplantation is a viable therapeutic option for selected patients with end-stage, irreversible lung disease. In our experience, the bronchial anastomosis remains an important keystone in the early success. Lung transplantation provides a good quality of life in patients free from infection and rejection. Nevertheless, chronic rejection resulting in obliterative bronchiolitis is a major problem in long-term survivors.

Adult↗