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Biomedical subjects

M Deltenre

Publications and source records attributed to M Deltenre.

At least 37 records · Page 2Linked to original sources
PubMed1990

A randomized, multi-observer, comparative evaluation of conventional fiberendoscopy and videoendoscopy in the upper GI tract.

In a comparative, histologically controlled study, no significant difference was found in the accuracy of conventional fiberendoscopy and videoendoscopy in the diagnosis of upper gastrointestinal tract lesions. Both techniques permitted accurate description of focal and/or ulcerative lesions, but videoendoscopy did not provide better sensitivity than fiberendoscopy in the diagnosis of superficial, non-ulcerative, inflammatory changes. The same results were obtained on checking the reproducibility of the macroscopic diagnosis by a delayed review of recorded videotapes.

Duodenal Diseases↗
PubMed1989

The reliability of urease tests, histology and culture in the diagnosis of Campylobacter pylori infection.

The accuracy of various staining techniques for immersion microscopy, of five media for culture and five urease test modalities for the detection of Campylobacter pylori infection is reported. It was found that 2% urea unbuffered gel preparation is the most accurate urease test (sensitivity: 89%, specificity: 98%) but a minimal amount of 10,000 CFU/ml is necessary to observe positivity and the sensitivity of urease tests drops to 52% in patients under antimicrobial treatment. For histological diagnosis, modified Giemsa staining was shown to be slightly superior to H&E. The most valuable diagnosis technique is culture when the biopsy specimen is transported and processed under appropriate conditions. A 94% sensitivity rate was observed with 'BCC agar', a new medium containing brain heart infusion, activated charcoal and horse serum.

Bacteriological Techniques↗
PubMed1989

[Clinical, endoscopic and histologic findings in 1,100 patients of whom 574 were colonized by Campylobacter pylori].

Of 1,100 patients checked by at least two diagnostic tests (urease, histology, culture) 574 (52.1 p. 100) were found to have Campylobacter pylori (C. pylori) in their antral mucosa. Significantly different frequencies of C. pylori (p less than 0.005) were evidenced in the group of patients with active gastroduodenal ulcer (212/298, 71 p. 100), in non-ulcer dyspepsia (NUD) with a previous history of GD ulcer (108/177, 61 p. 100) and NUD without antecedent history of GD ulcer (254/625, 41 p. 100). Whatever the group, males and immigrants were significantly at risk. Chronic alcoholism (greater than 60 g/day) and non-steroid anti-inflammatory drug (NSAID) intake were not predictive for the presence of C. pylori but smokers were significantly at risk when the total (n = 1,100) population was taken into consideration. C. pylori was found in 29 p. 100 of asymptomatic controls (n = 31). There was no significant difference in the frequency and intensity of symptoms when comparing C. pylori+ and C. pylori- patients. The macroscopic aspect of the antral mucosa was not predictive since 51 p. 100 of patients with normal endoscopy were C. pylori+. A strong correlation was observed between the incidence of C. pylori and the severity of gastritis at histology (p less than 0.001) and C. pylori was found in 7 p. 100 of patients with normal histology.(ABSTRACT TRUNCATED AT 250 WORDS)

Alcoholism↗
PubMed1988

Campylobacter pylori-associated gastritis: a double-blind placebo-controlled trial with amoxycillin.

We randomly assigned 45 adult patients with Campylobacter pylori-confirmed antral gastritis to 8 days of treatment with 1 g amoxycillin suspension twice a day, or placebo, according to a double-blind study design. At the end of therapy, 91% of patients treated with amoxycillin demonstrated clearance of the organism from the antrum, compared with 16% in the placebo group (p less than 0.001). Active antral gastritis resolved in 68% of patients in the amoxycillin group versus only 9% in the placebo group (p less than 0.001). No significant difference was observed when looking at the evolution of chronic only gastritis. No significant improvement was observed in the assessment of clinical symptoms and endoscopic appearance. Reappearance of C. pylori and significant worsening of the histological score of active gastritis was observed after 2 wk in all patients. In a second study phase, 18 patients initially not cleared of their bacteria received amoxycillin single blind for 14 days. Clearance of bacteria associated with improvement or resolution of active gastritis was observed in 72% of the cases. In this subgroup, all patients investigated after 1 month were recolonized with C. pylori and, again, had histological active gastritis. We conclude that amoxycillin is effective in treating active antral gastritis associated with C. pylori, but not in preventing relapses, which occur in all cases within 1 month after therapy.

Adult↗
PubMed1984

Acute hepatic injury associated with minocycline.

Minocycline hydrochloride hepatotoxic effect occurred in one patient. Unlike the usual histologic features of tetracycline-induced hepatic injury, fatty metamorphosis was predominantly macrovesicular . The patient recovered when drug therapy was withdrawn. Close observation of liver function variables is recommended in patients treated with high parenteral doses of minocycline, particularly in cases of pregnancy or renal disease.

Acute Disease↗
PubMed1983

Comparative study of ultrasound and ERCP in the diagnosis of hepatic, biliary and pancreatic diseases: a prospective study based on a continuous series of 424 patients.

A prospective study of the diagnostic yield of ultrasound (US) and ERCP was made on a continuous series of 424 patients. Technical failures were slightly more frequent with US (11%) than with ERCP (8%), while US proved more accurate than ERCP in the diagnosis of focal hepatic disease--94% of correct diagnosis versus 41% (n = 17). In diffuse hepatic disease (n = 63) the accuracy of both methods was the same--87% of correct diagnosis with US, 83% with ERCP. US had better performances (91%), while ERCP was more accurate in the diagnosis of common duct lithiasis or tumour (98% for ERCP, 36% for US). Although ERCP has a better diagnostic yield for pancreatic diseases (92% to 100% of correct diagnosis according to the lesions) associate complications, such as pseudo-cysts, abscess formation and extravasations are better demonstrated by US (95% of correct diagnosis versus 73%). The two methods thus prove to be complementary.

Acute Disease↗
PubMed1981

Special catheters for E.R.C.P.

The authors present the advantages of a needle and a metallic tip catheters allowing better success in conventional E.R.C.P. and in the cannulation of the accessory papilla. They consider these catheters as strictly necessary in the material available in endoscopic centers where E.R.C.P. is performed in routine.

Catheterization↗
PubMed1978

A new fatal complication of transtracheal aspiration.

A new, fatal complication of transtracheal aspiration is described in a cirrhotic patient. Death was related to gastrointestinal bleeding (rupture of oesophageal varices and Mallory-Weiss syndrome) due to unrestrainable coughing originating from transtracheal aspiration.

Aged↗
PubMedDate not supplied

An endoscopic Doppler probe for assessing intestinal vasculature.

Flexible fiberoptic endoscopes permit the physician to inspect the mucosal surface of the upper gastrointestinal tract and colon. However, this visual inspection provides little information about the underlying vascular supply to the intestinal wall. We tested the hypothesis that a Doppler probe could be constructed small enough to pass through the biopsy channel of a fiber endoscope and be used with it while performing endoscopy. The purpose would be to determine the location of patent arteries or veins, determine the magnitude and waveforms of the velocity in them, and estimate their contribution or potential contribution to intestinal bleeding. For this purpose, a miniature catheter probe (1.8 mm O.D. and 2 m in length) and an electronic range limited pulsed Doppler unit were developed. This probe and unit were studied in a series of 13 dogs to determine efficacy of detecting arterial and venous flow and to test the safety of the device. The duodenum was surgically exposed and opened in the region of the common bile duct (CBD). Arteries and veins surrounding the CBD were studied. Particular attention was directed to arterial structures which clinically pose a risk of bleeding when performing endoscopic papillotomy, a therapeutic technique in which the papilla of Vater is cut to release bile duct stones. The results of the study revealed that the probe could indeed detect arterial and venous structures accurately. There was no evidence that the probe produced any injury to the common bile duct or pancreas by histological or serum amylase studies and the device was determined safe and suitable for clinical evaluation.

Animals↗