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Biomedical subjects

M Delgado

Publications and source records attributed to M Delgado.

240 records · Page 14Linked to original sources
PubMedDate not supplied

Immunological survey in high altitude: effect on antibody production and the complement system.

In order to asses the effect of acute exposure to natural high altitude on some immunological mechanisms of mice, the primary response to SRBC was studied by the direct Hemolytic Plaque and Hemagglutination Tests. A control group was studied in Lima, Peru, 150 m. At high altitude (Ticlio, Peru, 4843 m), we found fewer spleen plaque-forming cells (PFC) and the maximal peak of PFC was delayed 1 day, as compared with the response at a lower altitude. Conversely, there was a higher serum concentration of 2-ME sensitive and resistant hemagglutinin antibodies at high altitude and the 19-S (2-ME sensitive) response was predominant during the first days at high altitude while the 7-S response was retarded. These results are interpreted as a stimulating effect of hypoxia on the 19-S antibody production rather than a cellular proliferation as far as the SRBC system is concerned. Serum concentrations of Igs G, M, A and the fraction C'3 of the Complement (B1C/B1A globulin) were determined in normal natives from three cities at different altitude levels: Morococha-Ticlio, 4680 m; La Oroya, 3700 m; and Tarma, 3051 m by the Radial Immunodiffusion Test. The serum concentration of C'3 was correlated with the total hemolytic activity of Complement (C'H50 method) in a group of natives from Morococha. The control group was of normal natives from Lima. No significant differences were found between resum concentration of Igs G, M and A in both groups, but there was a tendency for higher values of IgA at higher altitudes, and most sera in the high altitude group were above the normal IgG values for adults. The resum concentration of C'3 and the hemolytic activity of Complement were wound to be diminished in the high altitude group. These results are interpreted as an inhibitory effect of the altitude on the sequential activation and/or lysing capability rather than a reduction in the C'3 concentration.

Adult↗
PubMedDate not supplied

[Pheochromocytoma--apropos a clinical case].

A case of a 43-year-old woman with severe sustained hypertension resistant to many antihypertensive drugs, frequent hypertensive crisis and symptoms suggestive of pheochromocytoma (symptomatic triad) is presented. Three of the four determinations of the urinary catecholamines metabolites have been normal as it was the only determination of plasmatic catecholamines. Abdominal sonography and CT scan detected a left adrenal mass, that have been histologically confirmed, after surgery, to be a pheochromocytoma. After adrenalectomy, the patient symptoms disappeared but she maintained mild hypertension easily controlled with drugs. The finding of normal plasmatic and urinary catecholamines values in a patient with sustained hypertension may suggest that we are handling with a case of essential hypertension and a superimposed pheochromocytoma with paroxysmal secretion. Some considerations are made essentially about specificity and sensitivity of diagnostic tests.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

[Histopathological malignancy and prognosis of laryngeal cancer].

Two series of patients with laryngeal squamous cell carcinoma who underwent surgery for curative purposes were studied. Sixty patients were analyzed prospectively and 71 were analyzed retrospectively for clinical and pathological parameters of prognostic value. Clinical parameters (tumor site, T and N stage, patient age, alcohol and tobacco use, primary tumor or neck surgery) and histological parameters (tumor size, number of metastatic lymph nodes, T and N stage, WHO differentiation, Jakobsson and Glanz malignancy scores) were recorded and analyzed by multivariate analysis to find factors related independently with death from the tumor. In the retrospective study, the presence of positive surgical margins obscured other factors. In the prospective study, T and N stage and the Glanz and Jacobsson scores (in biopsies) were independently related with prognosis. Malignancy grading systems such as those of Jakobsson and Glanz should be included in treatment planning for patients with laryngeal carcinoma.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

[The clinical importance of bacteremia during tonsillectomy].

INTRODUCTION: Post-tonsillectomy bacteraemia is a well recognized aetiological factor in streptococcal endocarditis. Prophylactic penicillin has been recommended to reduce its incidence in susceptible patients undergoing tonsillectomy. Recent studies have shown a change in the microflora and an increase in the number of penicillin-resistant organisms in the tonsils of patients undergoing tonsillectomy. OBJECTIVE: The aim of this study was to assess the incidence of post-tonsillectomy bacteraemia, identify the associated organisms, and review the suitability of penicillin in prophylactic regimens. MATERIAL AND METHODS: 102 children were included. Blood culture samples were taken after removal of the first tonsil, which was randomly electrodissected or blunt dissected. Statistical analysis was performed using ANOVA. RESULTS: Of the 102 patients included in the study, 41 (40.1%) had positive post-tonsillectomy blood cultures. Haemophilus influenzae was isolated from 23 (56%) of the positive cultures and Streptococcus viridans from 15 (36.5%). Twenty-five percent of H. influenzae and 50% of the viridans group produced beta-lactamase. CONCLUSIONS: A beta-lactamase stable antibiotic would be more appropriate than penicillin for prophylaxis during tonsillectomy.

Anti-Bacterial Agents↗