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Biomedical subjects

M Del Zompo

Publications and source records attributed to M Del Zompo.

65 records · Page 4Linked to original sources
PubMed1979

Therapeutic efficacy of apomorphine combined with an extracerebral inhibitor of dopamine receptors in Parkinson's disease.

Apomorphine in combination with a peripheral dopamine receptor blocker (domeperidone) was administered to four parkinsonian patients in a double-blind placebo-controlled study. The therapeutic efficacy of apomorphine was not reduced by domperidone, while nausea, drowsiness, sedation, and arterial hypotension were prevented. Combination of domperidone with dopamine agonists may result in more effective treatment of Parkinson's disease.

Apomorphine↗
PubMed1978

Parkinsonism by haloperidol and piribedil.

Three groups of schizophrenic patients were treated with haloperidol, with a low dose of piribedil (a dopamine agonist), and with a combination of the two treatments, respectively. After a few days, all 7 patients treated with the drug combination showed marked rigidity and akinesia, while patients treated with haloperidol alone (4) and piribedil alone (4) showed either mild or no symptoms of parkinsonism. The drug combination induced mainly an akinetic-hypertonic syndrome, while tremors were absent or mild. The results suggest that low doses of the DA-agonist potentiate the extrapyramidal side effects of haloperidol by acting on self-inhibitory DA receptors, thereby blocking the compensatory increase in dopaminergic firing elicited by the neuroleptic agent.

Adolescent↗
PubMed1978

Apomorphine as a preferential stimulant of self-inhibitory dopamine receptors in man.

In man, non emetic doses of apomorphine elicit a series of behavioural, neurological and psychological changes which are difficult to ascribe to the stimulation of postsynaptic dopamine receptors. Since similar effects are elicited by neuroleptic drugs, the functional changes induced by apomorphine in man might be interpreted as being the result of a decreased dopaminergic activity. The sedation and sleep, the improvement of choreic movements and the antipsychotic effect induced by non emetic doses of apomorphine are prevented by specific dopamine receptor blockers. These responses therefore are mediated through a stimulation of dopamine receptors leading to a decreased dopaminergic transmission. This new type of receptors might be identified with the so called "self-inhibitory" dopamine receptors.

Apomorphine↗
PubMedDate not supplied

A double-blind study of minaprine versus amitriptyline in major depression.

This study was designed to compare the antidepressant effects of minaprine and amitriptyline in a group of 60 outpatients suffering from a major depressive episode as defined by the DSM III. The 6-week study was double-blind with a random allocation of treatment. Patients were treated with flexible daily doses of 200-300 mg of minaprine and 50-75 mg of amitriptyline. Both drugs showed significant global antidepressant efficacy with no significant difference between the two treatment groups. The Hamilton item 'psychomotor retardation' improved earlier with minaprine than amitriptyline. The incidence of anticholinergic adverse effects was significantly higher in the amitriptyline treatment group.

Adult↗