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Biomedical subjects

M Decramer

Publications and source records attributed to M Decramer.

148 records · Page 9Linked to original sources

Management of COPD according to guidelines. A national survey among Belgian physicians.

Current management of COPD by Belgian physicians was compared with the recommendations of the recently published GOLD guidelines. A random sample of 386 general practitioners and 86 pulmonologists filled in a questionnaire based on the GOLD guidelines and examining their attitudes towards COPD management. Several important deviations from the guidelines were noted. Only few GP's performed spirometry themselves and about 55% of the diagnoses were not based on spirometry. Both GP's and pulmonologists used inhaled corticosteroids considerably more often than prescribed by the guidelines, with 49% and 25% respectively, prescribing them to all COPD patients. Chronic systemic steroids were also overused in stable disease, with 55% of the GP's and 52% of the pulmonologists prescribing them in patients with repeated exacerbations. GP's did not use enough systemic corticosteroids and overused antibiotics in the treatment of exacerbations. Pulmonologists did not pay enough attention to pulmonary rehabilitation, as only 44% of them had a structured programme. Pulmonologists did not use non-invasive ventilation frequently enough in the treatment of exacerbations, as only 22% would use it in the correct indication. Both GP's and pulmonologists did not prescribe enough pharmacotherapy for smoking cessation, with 35% and 46%, respectively using it. Some interesting differences between Dutch and French speaking physicians were noted. These specific deviations from the guidelines will be addressed in a second phase implementation project.

Belgium↗

Isocapnic hyperventilation with cold air in healthy non-smokers, smokers and asthmatic subjects.

Isocapnic hyperventilation with subfreezing air was performed by 15 healthy non-smokers, 10 asymptomatic smokers and 9 asthmatics. All subjects had normal ventilatory function and airway resistance (Raw) before challenge. The hyperventilation was performed twice. In one session, total respiratory resistance (Rrs) and reactance (Xrs) were measured at various frequencies, using a forced oscillation technique; in another session, vital capacity (VC), forced expiratory volume in 1 s (FEV1), maximal expiratory flow rates (FEF) and Raw were determined. In non-smokers, no changes in FEV1, FEF nor Raw were observed, whereas Rrs increased significantly (+ 20% of the prechallenge value), without change in resonant frequency nor in the Rrs-frequency relationship. This suggests a constrictory effect on central airways (possibly a narrowing of the glottis) only. In smokers, Rrs showed a similar, though longer lasting, increase than in non-smokers. Besides, a significant change of the Rrs-frequency relationship and a reduction in FEF at 50% of VC was found, suggesting an involvement of peripheral airways also. In asthmatics, bronchial reactivity was more pronounced, resulting in significant changes in all parameters: Rrs increased by about 100% of the prechallenge value, and became highly frequency dependent; Xrs decreased markedly, resulting in an increase in resonant frequency of the respiratory system. Similarly, VC, FEV1 and FEF decreased. These alterations are compatible with a more generalized constriction of the peripheral as well as central airways.

Airway Obstruction↗