Biomedical subjects

M De Falco

Publications and source records attributed to M De Falco.

40 records · Page 3Linked to original sources

PubMedDate not supplied

Involvement of cdks and cyclins in muscle differentiation.

Myocyte differentiation is due to transcription of genes that characterize the phenotypic and biochemical identity of differentiated muscle cells. These are the myogenic regulatory factors (MRFs) MyoD, Myf5, myogenin and MRF4. Overexpression of cdk/cyclins has been reported to inhibit the activity of MyoD and prevent myogenic differentiation by different modalities. Unlike other cdk/cyclin complexes, overexpression of cdk9/cyclin T2a, enhances MyoD function and promotes myogenic differentiation. In addition, cyclin T2a interacting with a novel partner, PKN alpha, is able to strongly enhance the expression of myogenic differentiation markers, such as myogenin and Myosin Heavy Chain. So, cyclin T2a could stimulate myogenic differentiation interacting with different kinase partners Cdk9 or PKN alpha in a synergistic or antagonistic way.

Animals↗

PubMedDate not supplied

[Male breast cancer. Five years experience and literature review].

Male breast cancer is an uncommon disease and its aetiology, clinical behaviour and treatment is not well-known . Retrospective studies show that age and stage-matched breast cancer in men and women are compared. Nevertheless, the poor mammary tissue in man allow a rapid local infiltration, late diagnosis and poor survival rate. The Authors report their five years experience and with a short literature review they summarise what is currently known about this uncommon neoplasm in terms of prognostic factors, therapy and survival.

Breast↗

PubMedDate not supplied

[Granulomatous mastitis: diagnostic and therapeutic problems. Case report and review of the literature].

The granulomatous mastitis is uncommon inflammatory disease of the breast of unknown etiology. The diagnosis is obtained only through hystopathology. We report a case of woman, 41 years old, showing lesions of the breast, that caused strong pain with ulcerations sero-haematic secretion and axillary omolateral lymphadenopathy. The diagnostic workup (sonography, mammography, multiples FNAB of single lesions, the culture of cells and hormonal profile) showed an inflammatory aspecific lesions with presence of atipic cells in nipple's secretion and in FNAB of periareola lesion. We performed an excisional biopsy. The hystopathologic diagnosis showed a granulomatous mastitis, confirming the validity of our diagnostic and therapeutic choices. The excisional biopsy has allowed to avoid an overtreatment and obtain a good aesthetic result.

Adult↗

PubMedDate not supplied

[Needle aspiration cytology in thyroid surgery (our experience in 104 operated cases)].

In the least years Fine Needle Aspiration Biopsy (FNAB) is more and more becoming a routine exam in the thyroid diagnostics. Nevertheless, its exact role and diagnostic value is still an argument under discussion, in spite of well known usefulness and safety of the method. The aim of this study, based on our experience, is to verify, if and how much FNAB findings could have modified the diagnostic schedule, the surgical indications and the number of malignancies in a group of operated patients for thyroid nodular disease. In this experience a series of 104 patients have been studied in the Ia Clinica Chirurgica-Ia Facoltà, Università degli Studi di Napoli in the years 1988-90; the indication for a surgical treatment was due to a nodular thyroid disease. Aspiration cytology was performed in these patients before surgery and afterwards was determined the correlation between cytologic and hystological findings. The clinical and scan assessment also contributed to indicate the surgical management of the disease. On the basis of this study FNAB has to be considered as a quite reliable diagnostic tool in thyroid lesions; it results free of complications, with good sensitivity (75%), specificity (82.6%) and diagnostic accuracy (81.7%). A peculiar consequence of the use of cytology, is the increased number of adenoca (11.5%) preoperatively diagnosed, a percentage of which otherwise would have been a histopathological postoperative "surprise". However, the possibility of "false negative" and "false positive" lends further support to the concept that FNAB alone cannot determinate the choice between medical or surgical treatment of thyroid nodular lesions.

Adolescent↗