[Contribution to the Coffey-Mayo ureter implantation into the intestine].
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Acidosis↗
Biomedical subjects
M De Broe
Publications and source records attributed to M De Broe.
Blastomyces dermatitidis infection in the Congo. Report of a second autochthonous case.
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Adolescent↗
[Study of 2 forms of thalassemia in the Congolese: simple beta-thalassemic defect in a family and first case of beta-thalassodrepanocytosis with a high level of hemoglobin A].
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Adolescent↗
Gas chromatographic determination of drug levels for the evaluation of a combined hemoperfusion-hemodialysis treatment.
Recently, the use of a prolonged and combined procedure of hemoperfusion (HP) and hemodialysis (HD) was considered as a treatment for severely intoxicated patients caused by drug overdose. Working in cooperation with different hospitals, this laboratory has been involved with the toxicological analysis of biological samples taken during such a treatment. This paper describes the use of a combined HP/HD treatment, especially the evaluation of the system, by giving the analytical results obtained by gas chromatography. The methods utilized enable this application for routine toxicological analysis.
Adult↗
Urinary biomarkers as indicators of renal disease.
Using modern technology, minute quantities of LMWP, prostanoids, growth factors, intra-renal and extra-renal enzymes can be measured in urine. Excretory patterns that are characteristic for site and mechanism of renal injury often can be found. It is possible to recognise urinary biomarker patterns that suggest the putative environmental nephrotoxin. Our own studies performed in subjects with low level occupational and environmental exposures in New Jersey confirm the pattern specificity and threshold effects for Cr, Hg and Pb. In addition, we have been able to show that increased NAG and IAP excretion following Pb exposure correlates with current (blood Pb) but not with the cumulative Pb burden (bone Pb). The relatively specific characteristic patterns of biomarker excretion are lost as renal failure progresses. Moreover, renal injury that results in tubular proteinuria may not progress to renal failure. Nevertheless, urine biomarkers can help to establish acceptable levels and identify the need for long term surveillance to ascertain when clinical renal disease may result.
Adult↗
Extra-adrenal malignant phaeochromocytoma.
This paper describes a 35-year-old hypertensive woman presenting with two para-aortic catecholamine-secreting tumors. This bilateral lesion was successfully resected, but one year later proved to be malignant by spreading of the tumor to involve non-chromaffin tissues (liver and bones). A competitive inhibitor of alpha and beta receptors kept the blood pressure within reasonable limits.
Adult↗