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Biomedical subjects

M Davison

Publications and source records attributed to M Davison.

At least 73 records · Page 4Linked to original sources
PubMed1989

Effects of relative reinforcer frequency on complex color detection.

Pigeons were trained under a discrete-trials detection procedure in which one of a set of color stimuli was presented on the center key and a single response turned off the stimulus and illuminated two side keys. Single responses to one or the other side key produced occasional reinforcers depending on the value of the color stimulus. In Experiment 1, one color-stimulus set comprised 559, 564, 569, and 574 nm, and right-key pecks were occasionally reinforced following presentations of members of this set. The other stimulus set comprised 579, 584, 589, and 594 nm, and left-key pecks were occasionally reinforced following presentations of members of this set. Across seven experimental conditions, the left/(left + right) relative reinforcer frequency was varied from .1 to .9. In Experiment 2, one stimulus set contained only one member, 574 nm, and right-key responses were occasionally reinforced following its presentation. Over 12 experimental conditions, two manipulations were carried out. First, the number of stimuli comprising the other stimulus set was increased from one (579 nm) to two (579 and 584 nm) to three (579, 584, and 589 nm) and to four (579, 584, 589, and 594 nm), and left-key responses were reinforced occasionally following center-key presentations of members of this set. Second, for each stimulus combination, the left/(left + right) relative reinforcer frequency was varied from .1 to .5 to .9 across three experimental conditions. The principal finding of Experiments 1 and 2 was that reinforcers and stimuli interacted in their effects on behavior. In Experiment 3, pairs of adjacent stimuli (5 nm apart) in the range 559 to 594 nm were presented in each experimental condition, and the left/(left + right) relative reinforcer frequency was held constant at .5. The data from all three experiments were analyzed according to a detection model describing performance in multiple-stimulus two-response procedures. This model provided independent measures of stimulus discriminability, contingency discriminability, and bias. The analysis showed that (a) consistent with the color-naming function, pigeons were better able to discriminate between higher nanometer values than lower nanometer values; (b) their ability to discriminate between the stimuli was independent of the number of wavelengths comprising each stimulus set; (c) they allocated delivered reinforcers very accurately to the previously emitted response; and (d) no consistent biases emerged.

Journal Article↗
PubMed1988

Concurrent schedules: Interaction of reinforcer frequency and reinforcer duration.

Six pigeons were trained on concurrent variable-interval schedules with unequal reinforcer durations for the two responses. The schedules arranged on the two keys were kept equal while they were varied in absolute size. As the overall reinforcer rate was increased, both response-allocation and time-allocation measures of choice showed a trend toward indifference, and measures of sensitivity to reinforcer-duration ratios significantly decreased. Recent reports have shown that the generalized matching law cannot describe the changes in behavior allocation under constant delay-, duration-, or rate-ratios when changes are made in the absolute levels of each of these variables. The present results complement these findings by demonstrating that the concatenated generalized matching law cannot describe the interactions of two reinforcer variables on behavior allocation.

Journal Article↗
PubMed1988

Concurrent-chain performance: Effects of absolute and relative terminal-link entry frequency.

Six pigeons were trained in a concurrent-chain procedure with constant variable-interval 6-s variable-interval 12-s terminal links. Five groups of conditions were arranged. Within a group of conditions, the duration of one initial-link schedule was held constant and the duration of the other initial link was varied. The duration of the varied initial link was always longer than, or equal to, the constant initial-link duration. The duration of the shorter initial link was varied across groups of conditions from 5 s to 70 s. The data from each group were well described by the generalized matching law. Sensitivity (a) to the terminal-link entry ratio increased as the shorter initial-link duration increased, but appeared to reach an asymptote at shorter initial-link durations greater than 32 s. Terminal-link bias did not change with changes in shorter initial-link duration for the response-allocation data, but showed a small increase with increasing shorter initial-link duration for the time-allocation data.

Journal Article↗
PubMed1988

Delay of reinforcers in a concurrent-chain schedule: An extension of the hyperbolic-decay model.

Six pigeons were trained in concurrent-chain schedules with equal aperiodic initial links and delays to reinforcers in the terminal links. The terminal links always lasted 30 s. In Experiment 1, two reinforcers were delivered in each terminal link, with the first reinforcer delivered either 1 s (Experiment 1A) or 5 s (Experiment 1B) after choice. In these experiments, the delay between the first and second reinforcers in one terminal link was 10 s, and the delay between the first and second reinforcers on the other key was varied. This variation produced little change in preference. In Experiment 1C, the first and second delays on one key were 10 s, and on the other key they were varied within the restriction that the sum of delays was 20 s. Preference for the varied terminal link increased as the first delay was decreased. A hyperbolic model of the value of reinforcer delay provided a good description of the data from Experiment 1. In Experiment 2, a single reinforcer was delivered in each terminal link after a delay of either 0.2 or 19.8 s, and these delays were reversed between conditions. The initial-link schedule providing terminal-link access was varied from means of 5 s to 480 s. As the initial-link duration was increased, preference for the shorter delay became less extreme. An extension of the hyperbolic-decay model, in which the decay constant was a hyperbolic function of the initial-link duration, described the results well. Differences between the procedure used here (constant-duration terminal links) and that used in conventional concurrent-chain research precludes use of the model as a general account of concurrent-chain performance.

Journal Article↗
PubMed1988

Outcome of mechanical ventilation in Central Africa.

The outcome of mechanical ventilation is reported in a prospective series of 200 patients managed in an intensive care unit in Zambia. Fifty two patients survived (26%), and 46 patients were subsequently discharged from hospital (23%). Ten patients died in whom a complication of ventilation was a factor. Patients not expected to survive by the authors had a 96.3% mortality whereas patients with a chance of survival had a mortality rate of 58.8%. Two diagnostic groups were found to have a high mortality: head injury (85.1%) and non-traumatic coma (76.4%). This series is compared with similar series from developed countries and recommendations are made for the institution of mechanical ventilation in the developing world.

Coma↗
PubMed1987

Effects of response-allocation constraints on multiple-schedule performance.

Four pigeons were trained on multiple variable-interval schedules in which components alternated after a fixed number of responses had been emitted. In Part 1, each component change occurred after 20 responses; in Part 2, the number was 40; and in Part 3, the number of responses before change was 10. Component reinforcer rates were varied over five experimental conditions in each of Parts 1 to 3. Component response rates decreased as the specified number of responses per component was increased. However, the relation between component response-rate ratios and component reinforcer-rate ratios was independent of the specified number of responses per component, and was similar to that found when components alternate after fixed time periods. In the fourth part of the experiment, the results from Parts 1 to 3 were systematically replicated by keeping the component reinforcer rates constant, but different, while the number of responses that produced component alternation was varied from 5 to 60 responses. The results showed that multiple-schedule performance under component-response-number constraint is similar to that under conventional component-duration constraint. They further suggest that multiple-schedule response rates are controlled by component reinforcer rates and not by principles of maximizing overall reinforcer rates or meliorating component reinforcer rates.

Journal Article↗
PubMed1987

The interaction of stimulus and reinforcer control in complex temporal discrimination.

Six pigeons were trained in a discrete-trials signal-detection procedure to discriminate between a fixed-duration stimulus (5 s or 20 s) and a set of variable durations ranging from 2.5 s to 57.5 s in steps of 5 s. For each fixed-duration stimulus, the ratio of reinforcer frequencies contingent upon reporting the fixed versus the variable stimulus was systematically manipulated. Detection performance was well controlled by both the stimulus value and the reinforcer ratio. Both the discriminability between the fixed duration and the set of variable durations, and the discriminability between the fixed duration and each of the variable durations, were independent of the reinforcer-frequency ratio when discriminability was measured as log d. The sensitivity of response bias to reinforcement-ratio changes was independent of the value of the fixed duration, but was not independent of the discriminability of the variable durations from the fixed durations. Under current models, discriminability measures in complex temporal discrimination may be independent of biasing manipulations, but bias measures are not independent of stimulus values.

Animals↗
PubMed1986

Partial separation and functional characterization of guinea pig basophil-stimulating factor.

We have previously described T lymphocyte dependent guinea pig basophil growth from bone marrow precursors in vitro. In the current studies, basophil-stimulating factor (BSF) present in mitogen-stimulated splenic conditioned medium (CM) has been functionally characterized, utilizing an assay for BSF on nonadherent bone marrow target cells. BSF was found to be heat stable, nondialyzable, and inactivated by proteases. Monosaccharides known to inhibit guinea pig lymphokines yielded a unique profile of inhibition of BSF activity and nonidentity of BSF with guinea pig migration inhibition factor, interleukins 1 or 2, and granulocyte-macrophage colony-stimulating activity, from which BSF could be separated after gel filtration. BSF-containing CM also had no detectable interleukin-3 activity as measured in a murine assay. An inverse relation was found between interleukin 2 and BSF production by peritoneal exudate T cells (PEL) stimulated with antigen. Fractionation of serum-containing and serum-free CM demonstrated a molecular size for BSF of 50,000-65,000 daltons. Guinea pig BSF is a distinct T cell dependent lymphokine with an active protein moiety which may interact with target bone marrow cells through a cell surface carbohydrate receptor.

Animals↗
PubMed1986

Preference for multiple versus mixed schedules of reinforcement.

Five pigeons were trained in a concurrent-chain procedure. In the initial links, equal nonindependent variable-interval schedules were available concurrently on two keys. Completing the schedule on either key led to exclusive presentation of one of two further variable-interval schedules for a fixed period of time. During these terminal links, as many reinforcers as were scheduled could be obtained. If the response producing this terminal link occurred on one key, differential stimuli signaled which variable-interval schedule had been produced. If the response producing the terminal link occurred on the other key, no such differential stimuli were available. Once the fixed period of time elapsed, the initial links were reinstated. In Experiment 1, the period of time for which the terminal links were available was always 10 s and the absolute duration of the initial links was varied. Subjects preferred the alternative leading to the multiple schedule when the initial-link duration was short, but preferred the alternative leading to the mixed schedule when the initial-link durations were longer. In Experiment 2, both the initial-link duration and the duration of the terminal links were varied. The effect of initial-link duration was identical to that in Experiment 1 and there was no systematic effect of varying the terminal-link duration.

Journal Article↗
PubMed1986

Delayed reinforcement and delayed choice in symbolic matching to sample: Effects on stimulus discriminability.

Six pigeons were trained to peck a red side key when the brighter of two white lights (S(1)) had been presented on the center key, and to peck a green side key when the dimmer of two white lights (S(2)) had been presented on the center key. Equal frequencies of reinforcers were provided for the two types of correct choice. Incorrect choices, red side-key pecks following S(2) presentations and green side-key pecks following S(1) presentations, resulted in blackout. With 0-s delay between choice and reinforcement, the delay between sample presentation and choice was varied from 0 to 20 s. Then, with 0-s delay between sample presentation and choice, the delay between choice and reinforcement was varied from 0 to 20 s. Both types of delay resulted in decreased discriminability (defined in terms of a signal-detection analysis) of the center-key stimuli, but delayed choice had more effect on discriminability than did delayed reinforcement. These data are consistent with the view that the two kinds of delay operate differently. The effect of a sample-choice delay may result from a degradation of the conditional discriminative stimuli during the delay; the effect of a choice-reinforcer delay may result from a decrement in control by differential reinforcement.

Journal Article↗
PubMed1986

On the measurement of time allocation on multiple variable-interval schedules.

Six pigeons were trained on a modified multiple-schedule procedure. In a three-key chamber, the center key was lighted red or green, depending upon which component schedule was in effect. A response on this key transferred this color to each of two side keys, and responses on one of those keys produced reinforcers according to the component schedule. After 2 s, the side-key lights were extinguished, the center key was reilluminated, and a further center-key response was required to give access, as before, to the component schedules. Components alternated every 3 min. This limited-access procedure allowed both times spent switched into the side keys and time spent not switched in to be measured in the two components. Component reinforcer rates were varied over eight experimental conditions. Both component response rate and component time allocation were increasing functions of relative component reinforcer rate, and these functions were not significantly different. This finding implies that local response rates (responses divided by time switched in) were unaffected by changing component reinforcer rates on multiple schedules. Because a similar result was recently obtained for concurrent schedules, models of multiple and concurrent-schedule performance may need to consider only the time allocation of behavior emitted at equal tempo in the component schedules.

Journal Article↗
PubMed1986

A system for solar radiation data storage and analysis.

It is important for photodermatologists to have an accurate and continuous measurement of the ultraviolet radiation reaching the ground. This implies the establishment of a network of detectors, but for this to be a practical reality, it is essential that an accurate and convenient system be adopted for data storage and analysis. To this end we have developed a system which meets the following criteria: it is automatic; component costs are low: it uses a home microcomputer costing 400 pounds (less than $600); because processing is done by a computer, it is flexible; also, for the same reason, there is the facility for on-line display and on-line analysis; there are no significant errors: a modified computer circuit produces a temperature coefficient of 30 ppm/degrees C; reliability is good: 12 d of data were lost from all causes, including development, during 12 months of continuous use. The system described could form the basis of a practical UV-recording network.

Data Collection↗
PubMed1985

Determination of a behavioral transfer function: White-noise analysis of session-to-session response-ratio dynamics on concurrent VI VI schedules.

Six pigeons were exposed to concurrent variable-interval schedules in which the programmed reinforcer ratios changed from session to session according to a pseudorandom binary sequence. This procedure corresponded to the stochastic identification paradigm ("white-noise experiment") of systems theory and enabled the relation between log response ratios in the current session and log reinforcer ratios in all previous sessions to be determined. Such dynamic relations are called linear transfer functions. Both nonparametric and parametric representations of these, in the form of "impulse-response functions," were determined for each bird. The session-to-session response ratios resulting from the session-to-session pseudorandom binary variations in reinforcer ratios were well predicted by the impulse-response functions identified for each pigeon. The impulse-response functions were well fitted by a second-order dynamic model involving only two parameters: a time constant and a gain. The mean time constant was 0.67 sessions, implying that the effects of abrupt changes in log reinforcer ratios should be 96% complete within about five sessions. The mean gain was 0.53, which was surprisingly low inasmuch as it should equal the sensitivity to reinforcement ratio observed under steady-state conditions. The same six pigeons were subjected to a similar experiment 10 months following the first. Despite individual differences in impulse-response functions between birds within each experiment, the impulse-response functions determined from the two experiments were essentially the same.

Journal Article↗
PubMed1985

Component probability and component reinforcer rate as biasers of free-operant detection.

Six pigeons were trained on multiple schedules whose components were concurrent variable-interval extinction and concurrent extinction variable-interval schedules. In Experiments 1a and 1b the stimuli signaling the components were two different light intensities, and in Experiments 2a and 2b they were two identical intensities. The components of the multiple schedule changed probabilistically after each reinforcer. In Experiments 1a and 2a, the probability of presenting the components was varied over five conditions and a replication. In Experiments 1b and 2b, the component probability was .5 and the component reinforcer rates were varied systematically over five conditions and a replication. The data, analyzed according to the Davison-Tustin behavioral detection model, confirmed that the discriminability of the stimuli signaling the components was high when the stimuli were different, and low when the stimuli were the same. Discriminability, measured by log d, was unaffected by component probability variation and by component reinforcer-rate variation. When discriminability was high, bias, or the response allocation between the two keys, was more strongly affected by variation of reinforcer rate within components than by variation of component probability, but the reverse was found when discriminability was low. The results suggest that free-operant detection performance is controlled by the rates of reinforcers in periods of time in which stimuli signal differential contingencies. These periods comprise the components when the component stimuli are discriminable, and comprise the total session when the components are indiscriminable. An extension of the Davison-Tustin behavioral detection model that incorporates these results is presented.

Journal Article↗
PubMed1985

Performance in continuously available multiple schedules.

Three pigeons were given continuous access in their home cages to food reinforcement on two-component multiple variable-interval variable-interval schedules. The reinforcer rates in the two components were varied over seven experimental conditions, and a partial replication over five conditions was arranged one year later. When component reinforcer rates were unequal, ratios of component response rates were more extreme than ratios of obtained component reinforcer rates, a result which in a generalized-matching analysis is termed overmatching. This finding contrasts sharply with results obtained when multiple schedules are arranged in shorter sessions, in which performance is characterized by undermatching when subjects are deprived of food, and by matching, or equality between component response- and reinforcer-rate ratios, when deprivation is minimal. More molecular data obtained in two subsequent conditions suggested that this finding did not reflect local fluctuations or asymmetries in deprivation. Theories of multiple-schedule performance that predict that matching cannot be exceeded are disconfirmed by the present results.

Journal Article↗