A common antigenic determinant on human C4b and C3b.
Explore the source record for details and available documents.
Autoantibodies↗
Biomedical subjects
M Daveau
Publications and source records attributed to M Daveau.
Quantitative studies of Gm allotypes. V. Simultaneous presence of latent Gm allotypes and deficient Gm genes in a family with hypogammaglobulinaemic probands.
A study of Gm allotypes in a Caucasoid family with hypogammaglobulinaemic probands, showed qualitative (unexpected or lacking Gm allotypes) and quantitative (increased or decreased Gm contents) abnormalities in many relatives. Part of these observations can be most probably accounted for by inheritance of a GM1,17; 5,28 haplotype, not described in Caucasians yet, and by an in vivo expression of latent Gm genes.
Adolescent↗
Frequencies of Gm and Km allotypes in the population of Singapore, Sri Lanka and Punjabis in North India.
Serum samples from Sinhalese subjects, from Punjab and from Singapore have been studied. The Gm phenotypes found are very numerous and we can observe some similarities concerning the Gm gene frequencies between the Singapore Indians with the Indians of North India, and with the Sinhalese. In contrast, Gm gene frequencies found among Chinese and Malays from Singapore are quite different from those found among Indians of Singapore. Our results here are very similar to those obtained in Malaya studies.
China↗
Immunoglobulin Gm and Km genetic markers in Vietnamese.
The distribution of the G1m (1,2,3,17), G2m(23), G3m(5,10,11,13,14,15,21,28) and Km (1,2) allotypic markers has been examined in 122 unrelated Vietnamese subjects originating from all regions of Vietnam. The 13 observed phenotypes have been explained by means of 8 haplotypes: 5 'major' ones (which are also known to be usual in all other reported Mongoloid populations) and 3 'minor' ones. Consideration of gene frequencies allows easy integration of Vietnamese within the south-north cline of Gm haplotype distribution in East Asia, where they insert between Southern Chinese, on one hand, and Singapore as well as South Central Chinese on the other hand. The observed Km10.290 frequency value revealed to be of the same order of magnitude as the values reported for most other non-Thai Mongoloids.
Gene Frequency↗
[Urinary evaluation of 5-S-cysteinyldopa and seric evaluation of IgG4 subclass during follow-up of 27 primitive malignant melanomas (author's transl)].
27 patients with SSM or NM level IV and V have been submitted to a monthly evaluation of their level of 5-S-cysteinyldopa in the urine and IgG4 subclass in their sera. For 5 patients who entered the stage II of their disease during the follow-up, 3 had elevation of the 5S and 5 had large variations of IgG4. On 21 patients in clinical remission, 10 had conjunctly an increase of 5S and variations of IgG4. The predictional value of these tests is discussed.
Cysteinyldopa↗
Comparative frequencies of anti-IgA antibodies among patients with anaphylactic transfusion reactions and among normal blood donors.
Explore the source record for details and available documents.
Age Factors↗
IgG4 subclass in malignant melanoma.
Three hundred and ninety-seven sera from 185 melanoma patients were studied. These sera were classified into three groups according to stage of disease. An alteration in the level of the IgG4 subclass was found. It was related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in patients with stage II and III diseases (55 and 53%, respectively) than in patients with stage I(19%). The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biologic significance of the increase of IgG4 in melanoma remains obscure. The increase may be related to the development of facilitating antibodies of the IgG4 subclass.
Female↗
Gm and Inv allotypes in premature infants.
Using haemagglutination inhibition tests specific for Gm allotypes and similar tests for IgG4, the placental transfer of the four IgG subclasses from mother to foetus has been confirmed. The Gm phenotype of a cord serum is often identical to that in the corresponding maternal serum. However in 31 cases out of the 90 tested, Gm allotypes were present in the cord serum that were not present in the maternal serum. These allotypes produced by the foetus in utero are dependent on a paternal gene. The logarithm of the IgG level increase proportionately with gestational age (r = 0.59 p less than 0.001).
Female↗
Gm and Inv allotypes in French Guiana Indians.
Data from 302 individuals belonging to three populations of French Guiana Indians are reported. All the phenotypes except two can be explained by three haplotypes: Gm1,21, Gm1,2,21 and Gm1,10,11,25. The gene frequencies found in the present study are generally in accordance with those previously described among other South American Indians. For the Inv1,2 gene a high value has been found for the Wayanas and the Oyampis, but a difference appears for the Emerillons who possess a low frequency.
Blood Group Antigens↗
Gm and Inv allotypes in a Gypsy sample.
Serum samples from 226 Gypsies were tested for Gm(1,2,4,5,8,10,11,14,17,21,23,25) and for Inv(1,2). The Gm phenotypes found are very numerous and the more frequent among this population are: Gm(4,5, 8,10,11,14,17,23,25) and Gm(1,2,4,5,8,10,11,14,17,21,23,25). All the phenotypes except three can be explained by nine haplotypes: Gm4,5,8,10,11,14,23,25, Gm1,4,5,8,10,11,14,23,25, Gm4,5,8,10,11,14,25, Gm1,17,21, Gm1,10,11,17,25, Gm1,2,17,21, Gm1,8,17,21, Gm1,8,17,21,23 and Gm1,5,10,11,14,17. The haplotypes Gm1,17,21, Gm1,2,17,21, Gm4,5,8,10,11,14,25 (with or without Gm[ 3]) are all three common among Caucasoids, Gm1,4,5,10,11,14,23,25 (common among Mongoloids) and Gm1,5,10,11,14,17 (common to Negroids). For the Inv system, this population possesses a very low frequency of Inv(1) and Inv(2).
Ethnicity↗
[IgG in chromosomal aberrations: quantitative expression of Gm allotypes and some IgG subclasses in family studies].
Explore the source record for details and available documents.
Chromosome Aberrations↗
Differential modulation of complement factor H and C3 expression by TNF-alpha in the rat. In vitro and in vivo studies.
The biosynthesis of alternative regulatory complement protein factor H was investigated using both an in vivo rat model and an in vitro rat hepatocyte culture system, and compared to that of C3 component. Subcutaneous injection of a single dose of 20 micrograms of recombinant murine tumor necrosis factor-alpha (rmTNF-alpha) had no effect on factor H liver mRNA levels, while it increased C3 mRNA levels. In correlation with this, serum factor H levels remained unchanged after rmTNF-alpha injection, whereas C3 levels were increased. In contrast in vitro studies showed that rmTNF-alpha had no effect on factor H and C3 expression by rat hepatocytes. Recombinant human interleukin-1 alpha (rhIL-1 alpha) did not alter the expression of factor H, whereas it increased C3 expression, and recombinant human interleukin-6 (rhIL-6) stimulated expression of both proteins. This study shows that TNF-alpha is not directly responsible for the increased levels of factor H observed in vivo during induced inflammation in the rat. Its in vivo effect on C3 secretion might be secondary to the TNF-alpha-induced release of IL-1 and/or IL-6.
Animals↗
Interactions of the third component of human complement (C3) with tumour cells: evidence for presence of C3b acceptor sites and direct activation of C3 by tumour cells.
The interaction of C3 with different tumour cell lines was investigated. Our results indicated that nearly all the cell lines had C3b acceptors on their membranes. The binding of C3b was visualized by the detection of this protein on the cell surface with fluoresceinated anti-C3c serum. The involvement of proteases in the activation of C3 was demonstrated: complement-membrane fluorescence occurred in the presence of EDTA but was completely abolished with epsilon-aminocaproic acid. Experiments performed with purified C3 led to the conclusion that the protease activity might be the initial event for the activation of the alternative pathway by tumour cells.
Burkitt Lymphoma↗
Interleukin-6 (IL-6) and acute-phase proteins in rats with biliary sepsis.
We measured serum interleukin-6 (IL-6) and acute-phase proteins, alpha 1-acid glycoprotein (AGP) and alpha 2-macroglobulin (alpha 2M), after a retrograde intrabiliary bacterial infection in rats with biliary obstruction. Maximum serum IL-6 was obtained at 6 h in rats following inoculation of bacteria (10(6) CFU/ml E. Coli) in the bile duct and it was higher than that observed in rats undergoing a bile duct ligation or a laparotomy. There was a strict relationship between the level of IL-6 at 6 h and the modified levels of AGP and alpha 2M at 48 h. AGP and alpha 2M levels were the highest in sera of rats with bile duct infection as compared with those found in sera of rats with bile duct ligation or laparotomy. After inoculation of E. Coli or E. Fecalis, blood IL-6 level was always higher at 6 h in inferior vena cava as compared with that found in the supra hepatic vein. These results indicate that IL-6 is synthesized after a biliary sepsis and that its blood level is higher in the systemic circulation than in the local circulation.
Acute-Phase Proteins↗
Evidence that an autoantibody of IgG3 subclass against C3b discloses a C3 Nef activity in a pateint with partial lipodystrophy and glomerulonephritis.
Immunoglobulins of IgG3 subclass were purified from the serum of a patient with partial lipodystrophy and glomerulonephritis. The immunochemical data clearly showed that the immunoglobulins were directed against newly-formed determinants on C3 molecule when activation of complement occurred. This autoantibody property was related to the C3 nephritis factor activity present in the serum of the patient. Furthermore, this serum was unable to destroy cell bound C3b. This result suggested that this patient would presented a deficiency of C3b inactivation system.
Adult↗
IL-6-induced changes in synthesis of alpha 1-acid glycoprotein in human hepatoma Hep3B cells are distinctively regulated by monoclonal antibodies directed against different epitopes of IL-6 receptor (gp80).
The synthesis of the human acute-phase alpha 1-acid glycoprotein (AGP) is primarily controlled by IL-6 and IL-1 in liver cells. In the present study, monoclonal antibodies against human gp80 interleukin-6 receptor (IL-6R) were utilized to study the role of the IL-6R in the control of the IL-6-induced AGP synthesis in the human hepatoma Hep3B cell line. Two of the 4 MAbs used in this study, M164 and M195, identified 2 different epitopes involved in IL-6 binding and two others, M91 and M182, recognized epitopes not involved in IL-6 binding. Dose-response experiments indicated that up to 55% of AGP synthesis was inhibited by 10(5) ng/ml of MAbs 164 or 195 when Hep3B cells were treated by IL-6 for 48h. Kinetics of the inhibition of AGP synthesis after addition of anti-IL-6R indicated that the decrease of the IL-6-induced AGP synthesis by Hep3B cells was obtained immediately after the addition of the anti-IL-6R MAbs. Of the two MAbs not involved in IL-6 binding, M91 was unable to interfere with the IL-6-induced AGP synthesis whereas, surprisingly, M182 decreased it by about 25%. Since M182 was also able to interfere with the proliferative response of an IL-6 dependent plasma cell line, our results suggested that M182 may be directed to a structure involved in the IL-6/IL-6R gp130 complex formation.(ABSTRACT TRUNCATED AT 250 WORDS)
Animals↗
[IgG subclasses in malignant melanoma].
The 397 sera from 185 melanoma patients have been studied and classified in three groups according to the stage of disease. Our findings revealed an alteration of the level of IgG4 subclass which is related to the dissemination of disease. The percentage of abnormalities (either increased or decreased levels of IgG4) was more frequent in stage II and III (55% and 53% respectively) than in stage I (19%), The higher frequencies of high titers of IgG4 were essentially detected in advanced disease. The biological significance of the increase of IgG4 in melanoma remains obscure. It may be related to the development of facilitating antibodies of IgG4 subclass.
Humans↗
[IgG levels in the sera of melanoma patients (author's transl)].
397 sera from 185 melanoma patients have been tested. We classified our subjects into three groups, according to the stage of disease. An alteration of the level of IgG 4 sub-class was found and related to the extension of the disease. The percentage of abnormalities was more frequent in stage II and III (55 p. 100 and 53 p. 100) than in stage I (19 p. 100). High titers of IgG 4 subclass were essentially detected in advanced disease. The biological significance is discussed.
Humans↗