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Biomedical subjects

M Danis

Publications and source records attributed to M Danis.

210 records · Page 12Linked to original sources
PubMedDate not supplied

[Clinical and diagnostic features in seven cases of sacro-iliac tuberculosis. Contribution of bone scintigraphy (author's transl)].

Sacro-iliac tuberculosis was detected in seven African immigrants following attacks of sacrolumbar pain with fever, over a period of five years. Two of the patients had a previous history of tuberculosis, and in six out of the seven cases the osteo-articular affection was part of a multifocal tuberculous disease. The value of bone scintigraphy is discussed. Surgical treatment was performed together with medical therapy in three cases.

Adult↗
PubMedDate not supplied

[Pseudo-tumoral human African trypanosomiasis due to Trypanosoma gambiense. Clinical and tomodensitometry study (author's transl)].

The authors report an observation of african trypanosomiasis due to Trypanosoma Gambiense, clinical signs included massive and progressive hemiplegia, papillary edema and vascular shift from median line at arteriography. These pseudo tumoral clinical features are unusual in this disease. Asymetrical heterogenous hypodensities of the centrum semioval are dominant in the initial CT scanner aspect. The confrontation of CT scanner images to the clinical and evolutive data suggests the presence of associated cerebral edema and demyelination. With treatment, hypodensities were regressing while images of subcortical atrophy appeared. Lastly, in spite of severe general signs and the importance of neurological deficit, arsenical treatment associated with high doses of corticotherapy lead to a rapid improvement.

Adult↗
PubMedDate not supplied

[Malaria caused by multi-resistant Plasmodium falciparum contracted in Tanzania].

In a severe case of malaria, the chemosensitivity of a Plasmodium falciparum strain from a traveller to Tanzania who underwent chemoprophylaxis treatment with chloroquine (600 mg weekly) was evaluated in vitro. In the 28 hours maturation assay and a 72 hours proliferation assay, the strain proved to be highly resistant to chloroquine and to have a reduced sensibility to the sulfadoxin - pyrimethamin association.

Adult↗
PubMedDate not supplied

[Curative treatment of malaria Plasmodium falciparum, P. vivax and P. ovale malaria with mefloquine].

Mefloquine (WR 142-490, RO 21.5998), and antimalarial 4-quinoleine-methanol, active on multiresistant strains of P. falciparum is a resourceful product because of its pharmacocinetics and the possibility it opens of a single day curative therapy. Its mean half-live is 15 days, with important individual variations from 8 to 23 days as well as racial one within North-American, Asiatic or African patients. A 1,25 to 1,50 g dose divided in 2 or 3 intakes during 16 hours has proved to be effective in 34 P. falciparum cases. Lower doses, near 1 g seem sufficient for P. vivax (6 cases) and P. ovale fits (4 cases). Clinical and biological acceptance are good, according to this limited study. The use of mefloquine might nowadays be reserved for geographical areas where resistance to P. falciparum is significantly high. Its diffusion in Africa, south of the Sahara, though conceivable, might be discarded for the time beeing.

Adolescent↗
PubMedDate not supplied

[Drug resistance to malaria. Apropos of 17 cases in 2 years].

17 cases of resistant P. falciparum malaria are reported. They were observed in different populations: on one hand 9 Cambodian children refugees in France, on the other hand 8 French adults consulting after travels in South America or in South-East Asia. Different resistance levels to amino-4-quinolines and to a combination of sulfadoxine and pyrimethamine were found: they were more often from the RI type but sometimes from the RIII type also. 6 patients were treated with Mefloquine. Its activity was constant and rapid.

Adult↗
PubMedDate not supplied

[Evaluation of the QBC system for the diagnosis of malaria].

There are currently two methods for the direct diagnosis of malaria: the thin blood smear and the thick blood smear. A third cytological method, called the QBC malaria test (QBC), has been developed. The first studies comparing the three methods report conflicting results. Thus, there is a need for a study of the three methods in parallel and to evaluate the logistic factors which have not been previously assessed. In an analysis of imported malaria, one worker performed the three tests, blind, in parallel with each of 813 samples. The following values were determined: intrinsic validity; predictive values, species diagnostic power; and logistic factors. QBC had the following characteristics: sensitivity = 93.8%; specificity = 99.8%; positive predictive value = 99.3%; negative predictive value = 98.3%; correct species diagnosis = 91.3%; time required for test = 3.7 +/- 0.1 min; storage of tubes at +4 degrees C in the dark = 50 days; cost per test = 27.3 FF (as compared to 24 FF for thin smear and 17.3 FF for thick smear). Although unsuitable for use in countries where malaria is endemic, other than for some specialised situations, QBC is valuable for the diagnosis of imported malaria. In view of our findings, we suggest the following approach to diagnosis: use of the QBC and thin smear tests in parallel first reading the QBC result, as positivity contributes to reading the thin smear result for confirmation of species diagnosis and assessment of parasitaemia.

Acridine Orange↗
PubMedDate not supplied

[Serologic study of 51 cases of human trichinosis].

During the course of a recent epidemic of trichinosis two immunodiagnostic techniques were tested. Firstly indirect immunofluorescence (IF) using sections of the diaphram of infected mice and isolated trichine larvae. Secondly gel precipitation reactions, immunodiffusion and immunoelectrophoresis. It was observed that the induced specific antibodies appeared later than the clinical symptoms and the hypereosinophilia; the delay in appearance of the first positives detected being at least two to three weeks. Subsequently the titres rose rapidly and raised levels persisted for several months. Indirect immunofluorescence of excysted larvae remains the technique of choice, being rapid, sensitive and quantitative. The association of fluorescent and precipitation technique reduces the errors caused by cross reactions with other helminths.

Fluorescent Antibody Technique↗